| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
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| Research Abstract |
A New assay method for the screening of anti-emetic activity using frog, and the usefulness of this method were established. By using this method, the anti-emetic activities of 50 Chinese cude drug extracts were compared with the activities of known drugs, chlorpromazine, metoclopramide and ethyl-p-amino-benzoate. As the results, 18 compounds, [6], [8], [10]-shogaol, [6], [8], [10]-gingerol, magnolol, honokiol, beta-eudesmol, cryptomeridiol, rutin, phillyrin, rengyol, taraxasteryl palmitate, taraxasteryl acetate, IF-3, IF-4 and chlorogenic acid, were isolated as anti-emetic principlesby using modern chromatographical techniques, and the structures were identified by a variety of spectraldata.
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