| Project/Area Number |
02671120
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Univ of Tokyo |
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Principal Investigator |
OKABE Tetsuro Univ. of Tokyo M. D., 医学部(病), 助手 (80169135)
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| Co-Investigator(Kenkyū-buntansha) |
HAGIWARA Kouichi Univ. of Tokyo M. D., 医学部(病), 助手
SASAKI Nori Mitsui Memorial Hospital M. D., 内科, 医長 (40143432)
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| Project Period (FY) |
1990 – 1991
|
| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | G-CSF / placenta / receptor |
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| Research Abstract |
Granulocyte colony-stimulating factor(G-CSF)is a glycoprotein growth factor required for the proliferation and differentiation of progenitors of neutrophils. G-CSF is synthesized not only by macrophages but also by placental tissues. Interestingly, specific binding of human G-CSF was observed on human placental membranes and trophoblastic calls. The human G-CSF receptors on human placental membranes were shown to consist of two molecular species of 150 kDa and 120kDa that could be specifically cross-linked to ^<125>I-labeled G-CSF. From human placental tissues, we purified two types of G-CSF receptors with Kd of 600 and 210 pM.
Thus we have identified the receptors for human G-CSF on human placental membranes and traphoblastic cells, and the presence of the two types of receptors in these membranes suggest that human G-CSF plays some role in the feto-placental unit during human development.
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