Basic study for establishment of usefulness of a new inbred rat strain THA in brain science
| Project/Area Number |
02680041
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokai University |
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Principal Investigator |
SHIGETA Sadayoshi Tokai Univ.Sch.Med., Prof, 医学部, 教授 (90055707)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Hideki Cent.Inst.for Exp. Animals, Chief, 遺伝研究室, 室長 (30142053)
YOSHIDA Takahiko Tokai Univ.Sch.Med., Lecturer, 医学部, 講師 (90200998)
MISAWA Tetsuo Tokai Univ.Sch.Med., Lecturer, 医学部, 講師 (80056340)
AIKAWA Hiroyuki Tokai Univ.Sch.Med., Assist, 医学部, 助手 (40102850)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1992: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | LearningBehavior / InbredRat / Neuroscience / Neurotransmitter / 学習 / ラット / アセチルコリン / モノアミン / 免疫機能 / 遺伝子マップ / 近交系 / 高学習ラット / 脳内神経伝達物質 / 遺伝的プロファイル |
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| Research Abstract |
1.Neurobehavioral characteristics of the THA rat strain The THA rat strain performed superior learning and displayed small individual differences of learning performance, not only in the Sidman avoidance task, but also in two different tasks, namely, water E-maze and two-way shuttle avoidance, compared to the Jcl-Wistar strain. No apparent difference was present in developement, circadian rhysm of spontaneous activity, and open-field activity between the two strains.
2.Neurochemical characteristics of the THA rat strain The THA rat strain released much Ach compared to the Jcl-Wistar strain in striatum, but no significant difference was present in cortex between the two strain s. The THA rat strain showed high responce of Ach release to scopolamin, compared to the Jcl-Wistar strain in cortex, but no apparent difference was indicated in striatum between the two strains. No difference was present in release of mono-amine metabolites between the two strains.
3.Genetic characteristics of the THA rat strain The amylase-1 on the loci of the THA rat strain was different to that of the Jcl-Wistar strain.
4.Immunological characteristics of the THA rat strain The THA rat strain showed much T-cell subset, especially Th cell, compared to the Jcl-Wistar strain in the examination of subpopulation of lymphocyte. No difference were indicated in the proliferative response, and mixed lymphocyte reaction between the two strains.
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Report
(4 results)
Research Products
(8 results)
