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Mechanisms of proliferation of uterus in mice

Research Project

Project/Area Number 02804067
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 動物形態・分類学
Research InstitutionUniversity of Tokyo

Principal Investigator

MORI Takao  Faculty of Science The University of Tokyo Associate Professor, 理学部, 助教授 (80011659)

Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1991: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsmouse / uterus / prolactin / growth factors / estrogen / enzymes / プロテクチン / 細胞培養
Research Abstract

Uterus is the most important organ for the mammalian reproduction. Proliferation of the uterus is under the control of estrogen and progesterone. Recently it is known that action of estrogenis not direct, but indirect. Estrogen may produce some kinds of growth factors which directly affect the proliferation of uterus.
In this research project, I had designed to find novel growth factors which would control the proliferation of the uterine tissues. In our previous works, I have found that in mice anterior pituiary isogragfting into uterine lumen induces an early and high incidence of uterine adenomysis, a benign pathological disorder of the endometrial tissues, glands and stroma within the myometrium. Thus, I had used this animal model to find new growth factors in the uterus showing a marked proliferation of the tissues. However, I could not detect noel growth factors when the uterine tissues and fluid were analyzed by electrophoresis. The, I had examined the activities of both thymidylate synthetase and thymidine kinase, i. e., DNA-synthesizing enzymes. The results showed that both enzyme activities were significantly increased in the uterus with adenomyosis to two-fold those in the normal control uterus. This findings strongly suggest that the animal model developing uterine adenomyosis is useful for the study of the mechanisms of uterine proliferation. Thus, I would like to continue this research project by using the animal model of uterine adenomyosis in mice.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Takao Mori: "Coincidence of hyperinsalinemia and hyperylycemia after ectopic pituitary grafting in mice" Zoological Science. 8. 339-343 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takao Mori: "Induction of uterine adenomyosis by pituitary grafting and retardation of its development of hromo-criptine-mesilate(CB-154) in BALB/c mice" In Vivo. 5. 107-110 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tippaman Singtripop: "Development of uterine adenomyosis after treatment with dopamine antagonists in mice" Life Science. 49. 201-206 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takao Mori: "Animal model of uterine adenomyosis.Is prolactin a potent inducer of adenomyosis in mice?" Am.J.Obstet.Gynecal.165. 232-234 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroshi Nagasawa: "Effects of 6-methylene testosterone acetate on pnolactin secretion in relation to mammary tumorige nesis in SHN mice" Proc.6th Kyto Prolactin Conf.6. 13-20 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 守 隆夫: "実験動物の多面利用ー乳癌・子宮腺筋症・膵腫瘍を併発するSHNマウスを例にー" 畜産の研究. 45. 135-142 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 窪川 かおる: "ホルモン実験ハンドブック I.飼育と手技" 学会出版センタ-, 218 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 窪川 かおる: "ホルモン実験ハンドブック III実験のモデル" 学会出版センタ-, 181 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takao MORI: "Coincidence of hyperinsulinemia and hyperglycemia after ectopic pituitary grafting in mice." Zoological Science. 8. 339-343 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takao MORI: "Induction of uterine adenomyosis by pituitary grafting and retardation of its development by bromo-criptine-mesilate (CB-154) in BALB/c mice." In Vivo. 5. 107-110 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tippawan SINGTRIPOP: "Development of uterine adenomyosis after treatment with dopamine antagonists in mice." Life Science. 49. 201-206 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takao MORI: "Animal model of uterine adenomyosis : Is prolactin a potent inducer of adenomyosis in mice" American Journal of Obstet. Gynecol. 165. 232-234 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroshi NAGASAWA: "Effects of 6-methylenetesto sterone acetate on prolactin secretion in relation to mammary tumorigenesis in SHN mice" Proceeding 6th Kyoto Prolactin Conference. 6. 13-20 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takao MORI: "Sensitivity of the vagina and uterus of mice neonatally exposed to estrogen or androgen to postnatal treatment with estrogen or androgen." Proc. Soc. Exp. Biol. Med.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takasuki TAKAHASHI: "Occurrence of a novel 350-kDa serine proteinase in the fluid of porcine ovarian follicles and its increase during their maturation." Zoological Science.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takao MORI: "Coincidence of hyperimsalinemia and hyperglycemia after ectopic pitintary grafting in mice" Zoological Science. 8. 339-343 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takao MORI: "Induction of uterine adenomyosis by Rituitary grafting and retardation of its development by brimoーoriptineーmesilate(CDー154)in BALB/o mice" In Vivo. 5. 107-110 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tippaweon Singtripop: "Development of uterine adenomyosis after treatment with domamine antagonists in mice" Life Science. 49. 201-206 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takao Mori: "Animal model of uterine adenomyosis:Is prolactin a potent inducer of adenomyosis in mice?" Am. J. Obstet. Gynecal.165. 232-234 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hiroshi Nagasawa: "Efhects of 6ーmethylenetestosterone acetate on prolactin secretion in relation to mammary tumorigeneers in SHN mice" Proc.6th Kyto Prolactin Conf.6. 13-20 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 守 隆夫: "実験動物の多面利用ー乳癌子宮腺筋症,膵腫瘍を併発するSHNマウスを例にー" 畜産の研究. 45. 135-142 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 窪川 かおる: "ホルモン実験ハンドブックI飼育と手技" 学会出版センタ-, 218 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 窪川 かおる: "ホルモン実験ハンドブックIII実験のモデル" 学会出版センタ-, 181 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takao MORI: "Coincidence of hyperinsulinemia and hyperglycemia after ectopic pitwtary grafting in mice" Zoological Science. 8. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 守 隆夫: "実験動物の多面利用ー乳癌・子宮腺筋症・膵腫瘍を併発するSHNマウスを例にー" 畜産の研究 養賢堂. 45(1). 135-142 (1911)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hiroshi NAGASAWA: "Efhects of 6ーmethylenetestosterone a cetate on Prolactin secretion in relationslip to mammary tumorigenesis in SHN mice" Proc.5th Kyto Prolactin Conference. 5. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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