• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A Study on Biomechanics of Growth/resorption of Biological Tissue as Functional Adaptation

Research Project

Project/Area Number 02805014
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 材料力学
Research InstitutionOsaka University

Principal Investigator

MORIMOTO Yoshiharu  Osaka Univ., Fac. Eng. Sci., Associate Professor, 基礎工学部, 助教授 (20029573)

Co-Investigator(Kenkyū-buntansha) HAYASHI Kozaburo  Hokkaido Univ., Res. Inst. Appl. Elect., Professor, 応用電気研究所, 教授 (90026196)
TANAKA Masao  Osaka Univ., Fac. Eng. Sci., Associate Professor, 基礎工学部, 助教授 (40163571)
ONO Keiro  Osaka Univ., Med. Sch., Professor, 医学部, 教授 (70028330)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsBiomechanics / Mechanical Adaptation / Remodeling / Bone / Intervertebral Disc / Aorta / Tendon / リモデリング / 成長と変性
Research Abstract

The biological issues and systems have the ability to grow, resorb, and/or deform themselves according to the changes of their environments and routine behaviors. Such ability of mechanical adaptation by remodeling is intrinsic only to the biological issue and systems. The quantitative observation and its model description are fundamental in understanding such phenomena and applying such a function in engineering field. From this viewpoint, this study investigates the following topics from experimental/mathematical approaches.
1. Residual stress in bone and model of remodeling
The residual stress was released from the rabbit tibia-fibula system by the cutting method. It is found that the observed residual stress is comparable to that by the selfweight and its distribution is complex over the tibia. A model was proposed for the bone remodeling permitting the existence of the residual stress in the bone. The basic capability of the model was examined by simple case studies combined with the observed residual stress.
2. Experimental spondylosis model and effect of overuse
The experimental spondylosis was established by surgicalintervention in mice. Mechanical instability accelerates the process of intervertebral disc degeneration and the long term instability brings the spondylosis. Repetitive extension-flexion was loaded on spine of rabbits, and the delamination of annulus fibrosus and the early osteophyte formation are observed. This suggests the overuse is a factor in the pathogenesis of spondylosis.
3. Mechanical adaptation of aorta and patellar tendon
Goldblatt hypertension was induced in rats and it is found that the aortic wall changes in morphology first and then in the mechanical properties adoptng itself to the mechanical environment. The stress shielding in the patellar tendon of rabbits leads the immediate decrease of the mechanical properties and the reloading brings the gradual recovery. These results show the rapid mechanical adaptation in soft tissues.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 大野 和則: "Augumentation法によるStress Shielding" 骨・関節・靭帯. 3. 917-926 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sinpei Miyamoto: "Experimental Cervical Spondglosis in the Mouse" Spine. 16. S495-S500 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 松本 健郎: "ラット大動脈壁の高血不に対する力学的適応反応" 脈管学. 32. 35-38 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masao Tanaka: "Residual Stress of Biological Tissues and Model of Adaptation by Remodeling" Proc.3rd Int.Conf.on Residual Stress (Elsevier Science). (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 田中 正夫: "残留応力を許容する骨の力学的再構築に関する初期研究" 日本機械学会論文集A編. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Eiji Wada: "Experimental Spondylosis in Rabbit Spine -Overuse Could Accelerate the Spondylosis-" Spine.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Ohno, K. Yasuda, N. Yamamoto and K. Hayashi: "Effect of Stress Shielding in the Augumentative Ligament Reconstruction (in Japanese)" Bone, Joint & Ligament. 3-9. 917-926 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Miyamoto, K. Yonenobu and K. Ono: "Experimental Cervical Spondylosis in the Mouse" Spine. 16-10Suppl.S495-S500 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Matsumoto and K. Hayashi: "Mechanical Adaptation of Rat's Aorta to hypertension (in Japanese with English abstract)" J. Jpn. College Angiology. 32-1. 35-38 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Tanaka, T. Adachi, Y. Seguchi and Y. Morimoto: "Residual Stress of Biological Tissues and Model of Adaptation by Remodeling" Proc. 3rd Int. Conf. Residual Stress.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Tanaka and T. Adachi: "Preliminary Study on Mechanical Bone Remodeling Permitting Residual Stress (in Japanese with English abstract)" Trans. Jpn. Soc. Mech. Eng.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] E. Wada, S. Ebara and K. Ono: "Experimental Spondylosis in Rabbit Spine -Overuse Could Accelerate the Spondylosis-" Spine.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shinpei Miyamoto: "Experimental Cervical Spondylosis in the Mouse" Spine. 16. S495-S500 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Eiji Wada: "Experimental Spondylosis in Rabbit SpineーOveruse could accelerate the spondylosisー" Spine.

    • Related Report
      1991 Annual Research Report
  • [Publications] 田中 正夫: "残留応力を許容する骨の力学的再構築に関する初期研究" 日本機械学会論文集A編.

    • Related Report
      1991 Annual Research Report
  • [Publications] 田中 正夫: "残留応力を許容した骨の力学的再構築の速度形モデル" 日本機械学会第69期全国大会講演会講演論文集. 910ー62A. 544-546 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松本 健郎: "ラット大動脈壁の高血圧に対する力学的適応反応" 脈管学. 32. 35-38 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 真島 任史: "膝蓋腿の力学的特性に及ぼす負荷軽減の影響" 日本機械学会第2回バイオエンジニアリングシンポジウム講演論文集. 920ー7. 57-58 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 安達 泰治: "生体硬組織における残留応力測定の試み" 日本機械学会第2回バイオメカニクスカンファレンス講演論文集. 910ー8. 39-40 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Seguchi: "Residula Stress of Biological Tissues and the Model of Adaptation by Remodeling" Proc.the Third Intrenational Conference on Residual Stres. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] E.Wada: "Experimental Spondylosis in Rabbit spine" Transaction of Prthopaedic Research Society. 16. 634 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山本 憲隆: "膝蓋腱の力学的特性に及ぼす無負荷と過負荷の影響" 日本機械学会第2回バイオメカニクスカンファレンス講演論文集. 910ー8. 33-34 (1991)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi