| Project/Area Number |
02807056
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Niigata University School of Medicine (1991)
Tohoku University (1990) |
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Principal Investigator |
ABO Toru Niigata University School of Medicine, Department of Medical Zoology, Professor, 医学部, 教授 (30005079)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Takayuki Tohoku University School of Medicine, Second Department of Pathology Assistant p, 医学部, 助教授 (00113910)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | extrathymic T cells / hepatic sinusoids / intermediate TCR / alpha beta T cells / tumor immunity / NK cells / Tリンパ球 / 胸腺外分化 / 肝類洞 / αβT細胞 / γδT細胞 / intermediate TcR / ヌ-ドマウス / 胸腺摘出 |
|---|
| Research Abstract |
There exists a considerable number of unique T lymphocytes in the periphery in congenitally athymic nude mice, and in aged humans and animals with the in-voluted thymus. It is, therefore, suggested by several investigators that the extrathymic pathway of T cell differentiation may be present somewhere. We have recently demonstrated that such extrathymic T cell differentiation occurs in the hepatic sinusoids in humans and mice. This pathway of T cell differentiation resides phylogenetically earlier than the intrathymic pathway of T cell differentiation. Before and after thymic development, extrathymic T cells might work as the surveillance system for atypical cells generated in vivo by virtue of their autoreactivity. Extrathymic T cells have alpha beta TCR (and gamma delta TCR) of intermediate intensity and contain many auto-reactive T cell clones. The existence of the hepatic pathway could clearly explain the phenomenon "breakdown of self-tolerance", and occupies an important position of the immunology for aging, autoimmune disease, malignancy, bacterial infection, transplantation and allergy (immediate hypersensitivity).
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