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GENE EXPRESSION AND REGULATION OF NEUROTROPHINS AND THEIR RECEPTORS IN PERIPHERAL NEUROPATHIES

Research Project

Project/Area Number 02807085
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionAICHI MEDICAL UNIVERSITY

Principal Investigator

SOBUE Gen  DEPARTMENT OF INTERNAL MEDICINE ASSOCIATE PROFESSOR, 医学部, 助教授 (20148315)

Co-Investigator(Kenkyū-buntansha) MITSUMA Terunori  DEPARTMENT OF INTERNAL MEDICINE PROFESSOR, 医学部, 教授 (00111857)
KIMATA Kouji  INSTITUTE FOR MOLECULAR SCIENCE OF MEDICINE PROFESSOR, 分子医科学研究所, 教授 (10022641)
TERAO Sinichi  DEPARTMENT OF INTERNAL MEDICINE ASSISTANT, 医学部, 助手 (50188661)
KUMAZAWA Kazuhiko  DEPARTMENT OF INTERNAL MEDICINE ASSISTANT, 医学部, 助手 (20178065)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
KeywordsPeripheral nerves / neurotrophic factors / NGF / trk / laminin / sympathetic neuron / sensory neuron / 末梢神経障害 / 神経成長因子 / mRNA / BDNF / NTー3
Research Abstract

Gene expression of the neurotrophic factors and their receptors and related molecules was analyzed in the human, rat and mouse peripheral nervous system, particularly in the process of the peripheral nerve degeneration and regeneration. The molecules analyzed in this study included NGF, BDNF, LNGFR, trk,trkB, laminin A, B_1, B_2 chains and collagen type I, III, IV. Expression levels of mRNA for these molecules in the tissues were determined by Northern blot analysis. The findings obtained are as follows :
NGF, BDNF, LNGFR, laminin B_1, B_2, collagen type I, III, IV were synthesized in cultured Schwann cells inculture, and their mRNA levels were up- or down-regulated by exogenously administered cAMP analogues or by the contact with sensory neurons.
Human DRG neurons and sympathetic neurons express LNGFR, trk, trkBmRNAs, and which were likely down-regulated in the cases with neuropathy particularly in axonal type.
LNGFR were up- regulated and laminin B_1, B_2 were down-reglated in the axonal nerve lesions of humans as well as mouse and rats, but which were reversely reglated in associated with nerve regeneration
Neurite arborization (sprouting) was significantly enhanced by NGF on the post-matured DRG neurons, and this ability was well retained in the aging process, which may have corresponded to the well preserved functional NGF receptor (trk) expression on the aged these neurous. Those finding confirmed that these neurotrophic molecules and their receptors are up-or down-regulated in association with peripheral nerve de-and regeneration suggesting their significant roles in the neuropathies. Further study on the signal mechanism for these gene expressions is now required.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (80 results)

All Other

All Publications (80 results)

  • [Publications] SOBUE G,HASHIZUME Y,YASUDA T,MUKAI E,KUMAGAI T,MITSUMA T,Trojanowski JQ:"Phosphrylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells." Acta Neuropathol. 79. 402-408 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SOBUE G,NAKAO N,MURAKAMI K,YASUDA T,SAHASHI K,SASAKI Y,SAKAKI Y,MITSUMA T,TAKAHASHI A:"Type I familial amyloid polyneuropathy:A pathological study of the peripheral nervous system." Brain. 113. 903-919 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YASUDA T,SOBUE G,ITO T,MITSUMA T,TAKAHASHI A:"Nerve growth factor enhances neurite arborization of the adult sensory neurons:A study in single-neuron culture." Brain Res. 524. 54-63 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] KEN E,SOBUE G,YASUDA T,ITO T,MITSUMA T:"Effects of nerve growth factor on the geometry of adult rat sensory neurons." J Aichi Med Univ Ass. 18. 457-463 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YASUDA T,SOBUE G,ITO T,Doyu M,SUGOURA I,HASHIZUME Y,KATO K:"Human peripheral nerve sheath neoplasm:Expression of Schwann cell-related markers and their relation to malignant transformation." Muscle & Nerve. 14. 812-819 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] ITOH T,SOBUE G,MITSUMA T,KIMATA K,TAKAHASHI A:"Geometry of adult rat sensory neurons in culture:Its modulation by laminin." Neurosci Lett. 123. 212-216 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SOBUE G,YASUDA T,KACHI T,SAKAKIBARA T,MITSUMA T:"Chronic progressive sensory ataxic neuropathy:Clinicopathological features of idiopathic and Sjogren syndrome-associated cases." J Neurol. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Doyu M,SOBUE G,KEN E,KIMATA K,SHONOMURA T,YAMADA Y,MITWUMA T,TAKAHASHI A:"Laminin A,B1 and B2 chain gene expression in transected and regenerating nerves:Regulation by axonal signals." J Neurochem. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] MURAKAMI K,SOBUE G,IWASE S,MITSUMA T,MANO T: "Skin sympathetic nerve activity in acquired idiopathic generalized anhidrosis." Neurology. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] ITOH T,SOBUE G,YASUDA T,KIMATA K,MITSUMA T,TAKAHASHI A:"Geometric response to nerve growth factor is preserved in aged rat sensory neurons:A single-neuron culture study." Neurobiol Aging. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YAMAMOTO M,SOBUE G,Li Mei,ARAKAWA Y,MITSUMA T,KIMATA K:"cAMP-dependent regulation of nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF)and low-affinity nerve growth factor receptor(LNGFR)mRNA levels in cultured rat Schwann cells." Neurosci Lett. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] KUMAZAWA K,SOBUE G,YAMAMOTO K,MITSUMA T:"Segmental anhidrosis in the spinal dermatomes in Sjogren's syndrome-assoceated neuropathy." Neurology. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ross AH,SOBUE G,HOTTA H,Reddy U:"Biochemical characterization of the nerve growth factor receptor in neural-reated tumors." Curr Top Micro biol Immumol. 165. 27-36 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] KACHI T,SOBUE G,SOBUE I:"Central motor and sensory conduction in X-liked recessive bulbospinal neuronopathy." J Neurol Neuro surg Psychiatry. 55. 394-397 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] ITOH T,SOBUE G,KEN E,MITSUMA T,TAKAHASHI A,Trojanowski JQ:"Phosphorylated high molecular weight neurofilament protein in the peripheral motor,sensory and sympathetic neuronal perikarya:System-dependent normal variations and changes in amyotrophic lateral sclerosis and multipe system atrophy." Acta Neuropathol. 83. 240-245 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SOBUE G,Doyu M,WATANABE M,HAYASHI F,MITSUMA T:"Extensive demyelinating changes in the peripheral nerves of Crow-Fukase syndrome." Acta Neuropathol. 84. 171-177 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SOBUE G,TERAO S,KACHI T,KEN E,HASHIZUME Y,MITSUMA T,TAKAHASHI A:"Somatic motor efferents in multiple system atrophy with autonomic failure:A clinicopathological study." J Neurol Sci. 112. 113-125 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Doyu M,SOBUE G,MUKAI E,KACHI T,YASUDA T,MITSUMA T,TAKAHASHI A:"Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene." Ann Neurol. 32. 707-710 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SOBUE G,Doyu M,KACHI T,YASUDA T,MUKAI E,KUMAGAI T,MITSUMA T:"Subclinical phenotypic expressions in heterozygous females of X-linked recessive bulbospinal neuronopathy." J Neurol Sci. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Doyu M,SOBUE G,UCHIDA M,IWASE T,MITSUMA T,TAKAHASHI A:"Very-late-onset X-linked recessive bulbospinal neuronopathy;mild phenotypic expression and mild elongation of tandem CAG repeat of androgen receptor gene." J Neurol Neuro surg Psychiatry. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 祖父江 元:"末梢神経障害の成因をめぐって:末梢神経障害とSchwann細胞" 臨床神経. 30. 1358-1360 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 祖父江 元,安田 武司,権 英淑,劉 莉〓,満間 照典:"ヒト末梢神経生検におけるnerve growth factor receptor の免疫組織染色の意義 -変性線維検索のマーカーとして-" 医学のあゆみ. 155. 257-258 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 祖父江 元:"成熟後の交感神経細胞の構造と機能の調節維持機構-標的器官とtrophic factorの役割-" 自律神経. 28. 437-441 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 経 英淑,祖父江 元,伊藤 高行,道勇 学,満間 照典:"ラットの末梢神経系とくに第一次感覚神経における神経成長因子受容体の発見 -成長・老化と神経挫減の影響-" 愛知医大誌. 19. 171-180 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 祖父江 元:"末梢神経の再生とその調分因子:low affinity NGF receptor と laminin" 末梢神経. 2. 37-43 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sobue G, Hashizume Y, Yasuda T, Mukai E, Kumagi T, Misuma T, Trojanowski JQ: "Phosphrylated high molecular weight neurolilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral hom cells." Acta Neuropathol. 79. 402-408 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sobue G, Nakao N, Murakami K, Yasuda T, Sahashi K, Sasaki Y, Sakaki Y, Mitsuma T, Takahashi A: "Type I familial amyloid polyneuropathy : A pathological study of the peripheral nervous system" Brain. 113. 903-919 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yasuda T, Sobue G, Ito T, Mitsuma T, Takahashi A: "Nerve growth factor enhances neurite arborization of the adult sensory neurons : A study in single-neuron culture." Brain Res. 524. 54-63 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ken E, Sobue G, Yasuda T, Ito T, Mitsuma T: "Effects of nerve growth factor on the geometry of adult rat sensory neurons" J Aichi Med Unuv.Ass. 18. 457-463 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yasuda T, Sobue G, Ito T, Doyu M, Sugiura I, Hashizume Y, Kato K: "Human peripheral nerve sheath neoplasm : Expression of Schwann cell-related markers and their relation to malignant transformation" Muscle & Nerve. 14. 812-819 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Itoh T, Sobue G, Yasuda T, Mitsuma T, Kimata K, Takahashi A: "Geometry of adult rat sensory neurons in culture : Its modulation by laminin" Neurosci Lett. 123. 212-216 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ross AH, Sobue G, Hotta H, Reddy U: "Biochemical characterization of the nerve growth factor receptor in neural-reated tumors" Curr Top Microbio Immunol. 165. 27-36 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kachi T, Sobue G, Sobue I: "Central motor and sensory conduction in X-liked recessive bulbospinal neuronopathy" J Neurosurg Psychiatry. 55. 394-397 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Itoh T, Sobue G, Ken E, Mitsuma T, Takahashi A, Trojanowski JQ: "Phosphorylated high molecular weight neurofilament protein in the peripheral motor, sensory and sympathetic neuronal perikarya : System-dependent normal variations and changes in amyotrophic lateral sclerosis and multipe system strophy" Acta Neuropathol. 83. 240-245 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sobue G, Doyu M, Watanabe M, Hayashi F, Mitsuma T: "Extensive demyelinating changes in the periphcral nerves of Crow-Fukase syndrome" Acta Neuropathol. 84. 171-177 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sobue G, Terao S, Kachi T, Ken E, Hashizume Y, Mitsuma T, Takahashi A: "Somatic motor efferents in multiple system atrophy with autonomic failure : A clinicopathological study" J Neurol Sci. 112. 113-125 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Doyu M, Sobue G, Mukai E, Kachi T, Yasuda T, Mitsuma T, Takahashi A: "Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene" Ann Neurol. 32. 707-710 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sobue G, Yasuda T, Kachi T, Sakakibara T, Mitauma T: "Chronic progressive sensory ataxic neuropathy : Clinicopathological features of idiopathic and Sjogren syndrome-associated cases" J Neurol. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Doyu M, Sobue G, Ken E, Kimata K, Shinomura T, Yamada Y, Mitsuma T, Takahashi A: "Laminin A, B1 and B2 chain gene expression in transected and regenerating nerves : Regulation by axonal signals" J Neurochem. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Murakami K, Sobue G, Iwase S, Mitsuma T, Mano T: "Skin sympathetic nerve activity in acquired idiopathic generalized anhidrosis" Neurology. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Itoh T, Sobue G, Yasuda T, Kimata K, Mitsuma T, Takahashi A: "Geometric response to nerve growth factor is pre- served in aged rat sensory neurons : A single-neuron culture study" Neurobiol Aging. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamamoto M, Sobue G, LiMei, Arakawa Y, Mitsuma T, Kimata K: "cAMP-dependent regulation of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and low-affinity nerve growth factor receptor (LNGFR) mRNA levels in cultured rat Schwann cells" Neurosci Lett. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kumazawa K, Sobue G, Yamamato K, Mitsuma T: "Segmental anhidrosis in the spinal dermatomes in Sjogren's syndrome-associated neuropathy" Neurology. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sobue G, Doyu M, Kachi T, Yasuda T, Mukai E, Kumagai T, Mitsuma T: "Subclinical phenotypic expressions in heterozygous females of X-linked recessive bulbospinal neuronopathy" J Neurol Sci. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Doyu M, Sobue G, Uchida M, Iwase T, Mitsuma T, Takahashi A: "Very-late-onset X-linked recessive bulbospinal neuronopathy ; mild phenotypic expression and mild elongation of tandem CAG repeat of androgen receptor gene" J Neurol Neurosurg Psychiatry. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sobue G,Hashizume Y,Yasuda T,Mukai E,Kumagai T,Mitsuma T,Trojanowski JQ:"Phosphrylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells." Acta Neuropathol. 79. 402-408 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sobue G,Nakao N,Murakami K,Yasuda T,Sahashi K,Sasaki Y,Mitsuma T,Takahashi A:"Type I familial amyloid polyneuropathy:A pathological study of the peripheral nervous system." Brain. 113. 903-919 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yasuda T,Sobue G,Ito T,Mitsuma T,Takahashi A:"Nerve growth factor enhances neurite arborization of the adult senosory neurons:A Study single-neuron culture." Brain Res. 524. 54-63 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ken E,Sobue G,Yasuda T,Ito T,Mitsuma T:"Effects of nerve growth factor on the geometry of adult senosory neurons." J Aichi Med Univ Ass. 18. 457-463 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yasuda T,Sobue G,Ito T,Doyu M,Sugiura I,Hashizume Y,Kato K:"Human peripheral nerve sheath neoplasm:Expression of Schwann cell-related markers and their relation to malignant transformation." Muscle&Nerve. 14. 812-819 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Itoh T,Sobue G,Yasuda T,Mitsuma T,Kimata K,Takahashi A:"Geometry of adult rat sensory neurons in culture:Its modulation by laminin." Neurosci Lett. 123. 212-216 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sobue G,Yasuda T,Kachi T,Sakakibara T,Mitsuma T:"Chronic progressive sensory ataxic neuropathy:Clinicopathological features of idiopathic and Sjogren syndrome-associated cases." J Neurol. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Doyu M,Sobue G,Ken E,Kimata K,Shinomura T,Yamada Y,Mitsuma T,Takahashi A:"Laminin A,B1 and B2 chain gene expression in transected and regenerating nerves:Regulation by axonal signals." J Neurochem. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Murakami K,Sobue G,Iwase S,Mitsuma T,Mano T: "Skin sympathetic nerve activity in acquired idiopathic generalized anhidrosis." Neurology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Itoh T,Sobue G,Yasuda T,Kimata K,Mitsuma T,Takahashi A:"Geometric response to nerve growth factor is preserved in aged rat sensory neurons:A single-neuron culture study" Neurobiol Aging. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamamoto M,Sobue G,Li Mei,Arakawa Y,Mitsuma T,Kimata K:"cAMP-dependent regulation of nerve growth factor(NGF),brain-dirived neurotrophic factor(BDNF)and low-affinity nerve growth factor receptor(LNGFR)mRNA levels in cultured rat Schwann cells." Neurosci Lett. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kumazawa K,Sobue G,Yamamato K,Mitsuma T:"Segmental anhidrosis in the spinal dermatomes in Sjogren's syndrome-associated neuropathy." Neurology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ross AH,Sobue G,Hotta H,Reddy U:"Biochemical characterization of the nerve growth factor receptor in neural-reated tumors." Curr Top Micro biol Immunol. 165. 27-36 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kachi T,Sobue G,Sobue I:"Central motor and sensory conduction in X-liked recessive bulbospinal neuronopathy" J Neurol Neuro surg Psychiatry. 55. 394-397 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Itoh T,Sobue G,Ken E,Mitsuma T,Takahashi A,Trojanowski JQ:"Phosphorylated high molecular weight neurofilament protein in the peripheral motor,sensory and sympathetic neuronal perikarya:System-dependent normal variations and changes in amyotrophic lateral sclerosis and multipe system atrophy." Acta Neuropathol. 83. 240-245 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sobue G,Doyu M,Watanabe M,Hayashi F,Mitsuma T:"Extensive demyelinating changes in the peripheral nerves of Crow-Fukase syndroome." Acta Neuropathol. 84. 171-177 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sobue G,Terao S,Kachi T,Ken E,Hashizume Y,Mitsuma T,Takahashi A:"Somatic motor efferents in multiple system atrophy with autonomic failure:A clinicopathological study." J Neurol Sci. 112. 113-125 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Doyu M,Sobue G,Mukai E,Kachi T,Yasuda T,Mitsuma T,Takahashi A:"Severity of X-linked ricessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene." Ann Neurol. 32. 707-710 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sobue G,Doyu M,Kachi T,Yasuda T,Mukai E,Kumagai T,Mitsuma T:"Subclinical phenotypic expressions in heterozygous females of X-linked recessive bulbospinal neuronopathy." J Neurol Sci. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Doyu M,Sobue G,Uchida M,Iwase T,Mitsuma T,Takahashi A:"Very-late-onset X-linked recessive bulbospinal neuronopathy;mild phenotypic expression and mild elongation of tandem CAG repeat of androgen receptor gene." J Neurol Neuro surg Psychiatry. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 祖父江 元:"末梢神経障害の成因をめぐって:末梢神経障害とSchwann細胞" 臨床神経. 30. 1358-1360 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 祖父江 元,安田 武司,権 英淑,劉 莉〓,満間 照典:"ヒト末梢神経生検におけるnerve growth factor receptorの免疫組織染色の意義 ー変性線維検索のマーカーとしてー" 医学のあゆみ. 155. 257-258 (1990)

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      1992 Annual Research Report
  • [Publications] 祖父江 元:"成熟後の交感神経細胞の構造と機能の調節維持機構ー標的器官とtrophic factorの役割ー" 自律神経. 28. 437-441 (1991)

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      1992 Annual Research Report
  • [Publications] 権 英淑,祖父江 元,伊藤 高行,道勇 学,満間 照典:"ラットの末梢神経系とくに第一次感覚神経における神経成長因子受容体の発現ー成長・老化と神経挫滅の影響ー" 愛知医大誌. 19. 171-180 (1991)

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      1992 Annual Research Report
  • [Publications] 祖父江 元:"末梢神経の再生とその調分因子:low affinity NGF receptorとlaminin" 末梢神経. 2. 37-43 (1991)

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      1992 Annual Research Report
  • [Publications] Yasuda T.,Sobue G.ea al: "Nerve growth factor enhances neurite arborization of adult rat sensory neurons." Brain Res.524. 54 (1990)

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      1991 Annual Research Report
  • [Publications] Yasuda T.,Sobue G.ea al: "Human peripheral nerve sheath neoplasm:expression of schwann cell-related markers and their relation relation to malignant transformation." Muscle & Nerve. 14. 812-819 (1991)

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      1991 Annual Research Report
  • [Publications] Ito T.,Sobue G.et al.: "Geometory of adult rat sensory neurons in culture:effects of laminin." Neurosci.Lett.123. 212-216 (1991)

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      1991 Annual Research Report
  • [Publications] Kachi T.,Sobue G.et al.: "Central motor and sensory conduction in X-linked recessive bulbospinal neuronopathy." J.Neurol.Neurosurg.Psychiatry.

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      1991 Annual Research Report
  • [Publications] Itoh T.,Sobue G.et al.: "Phosphorylated high molecular neurofilament protein in the peripheral motor,sensory and sympathetic neuronal perikarya." Acta Neuropathol.

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      1991 Annual Research Report
  • [Publications] Yasuda T.,Sobue G.et al: "Nerve growth factor enhances neurite arborization of adult rat sensory neurons." Brain Res.524. 54 (1990)

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      1990 Annual Research Report
  • [Publications] Yasuda T.,Sobue G.et al: "NGF receptor expression in human benign nerve sheath tumor." Mucle & Nerve.

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      1990 Annual Research Report
  • [Publications] Ito T.,Sobue G.et al: "Geometry of adult rat sensory neurons in culture:effects of laminin" Neurosci.Lett.

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      1990 Annual Research Report
  • [Publications] Doyu M.,Sobue G.et al: "NGF receptor gene expression in neurofibromas and schwannomas."

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      1990 Annual Research Report
  • [Publications] Ken E.,Sobue G.et al: "Effects of nerve growth factor on the geomery of adult sensory neurons." J.Aichi.Med.Univ.Assoc.18. 457-463 (1990)

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      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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