• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Relationship between Gastrointestinal Myoelctric Activity and Portal Venous Flow before and after Truncal Vagotomy, Gastrectomy with or without Vagotomy.

Research Project

Project/Area Number 02807118
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionFirst Department of Surgery, Niigata University School of Medicine

Principal Investigator

MATSUO Hitoshi  Niigata University, First Department of Surgery, Instructor, 医学部, 助手 (50199759)

Co-Investigator(Kenkyū-buntansha) SATO Kenji  Niigata University, First Department of Surgery, Resident, 医学部, 医員
TAMIYA Yohichi  Niigata University, First Department of Surgery, Instructor, 医学部, 助手 (70163681)
MATSUBARA Yohichi  Niigata University Hospital, First Department of Surgery, Assistant Professor, 医学部附属病院, 講師 (90111723)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsGastrectomy / Truncal Vagotomy / Gastrointestinal Motility / Portal Venous Flow / Solid Meal / Liquid Meal / 固型食 / 空腹期強収縮波群
Research Abstract

During the fasting, gastrointestinal tract showed periodic activity, and the migrating myoelectric complex (MMC) occurred regularly in the stomach and the duodenum, and propagated distally. Feeding dramatically disrupted MMCs, then uniform electrical activity of the fed pattern took place in the entire intestine.
The fasting portal venous flow (PVF) showed slight fluctuation, according to the gastroduodenal activity. Postprandial changes in PVF were closely correlated with intestinal activity. After ingestion of meal, PVF soon elevated and reached plateau within 30min. Period of increased PVF persisted for more than 2 hours, then the PVF gradually decreased to the fasting value.
There was significant correlation between the time required for reappearance of MMC in the upper jejunum (MMC-inhibition time) and the PVF-increasing time (<mean fasting PVF + 2SD).
After truncal vagotomy (TV), periodic appearance of MMCs ws observed in the small intestine, while few MMCs occurred in the stomach even after 24-h fasting. Feeding abolished MMCs from the intestine, converting the fasting pattern to the feeding pattern.
After TV, changes in PVF after feeding showed a various patterns. Some postprandial PVF increased rapidly, while another very slowly.
Both MMC-inhibition time and PVF-increasing time varied in each day and between dogs. The correlation between MMC-inhibition time and PVF-increasing time was not seen after TV.
In conclusion, motility disorders after vagotomy influence on intestinal circulation, causing a disturbed portal blood supply to the liver.
To clarify the effects of distal partial gastrectomy with or without vagotomy on intestinal motility and circulation, Further studies on the intestinal myoelectric activity and PVF will be required.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 佐藤 賢治,松尾 仁之,島影 尚弘,小野 一之,松原 要一,武藤 輝一: "空腹期および流動食投与下における消化管筋電図と門脈血流量に関する実験的研究ー迷走神経切離術前後の比較ー" 日本平滑筋学会雑誌. 26(6). 451-453 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 佐藤 賢治,松尾 仁之,島影 尚弘,小野 一之,武田 信夫,田宮 洋一,松原 要一,武藤 輝一: "迷走神経切離術が門脈血流量および消化管運動に及ぼす影響に関する実験的研究" 日本平滑筋学会雑誌. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sato, K., Matsuo, H., Shimakage, N., Ono, K., Matsubara, Y., and Muto, T.: "Relationship between gastrointestinal myoelectric activity and portal venous flow after vagotomy in conscious dogs. Effects of liquid meal" Jpn. J. Smooth Muscle Res.26. 354-356 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sato, K., Matsuo, H., Shimakage, N., Ono, K., Takeda, N., Tamiya, Y., Matsubara, Y., and Muto, T.: "Relationship between gastrointestinal myoelectric activity and portal venous flow before and after trucal vagotomy." Jpn. J. Smooth Muscle Res.27.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Matsuo, H., Matsubara, Y., Tamiya, Y., Nakamura, S., Shimakage, N., Sato, K., Ono, K., and Muto, T.: "Effects of different rout of nutrients administration on migrating myoelectric complex. -- Comparison of enteral nutrition and parenteral nutrition --" Pathogenesis and Treatment of the Postoperative Motility Disorders. Medical Tribune Inc.74-85 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 佐藤 賢治,松尾 仁之,島影 尚弘,小野 一之,武田 信夫,田宮 洋一,松原 要一,武藤 輝一: "迷走神経切離術が門脈血流量および消化管運動に及ぼす影響に関する実験的研究" 日本平滑筋学会雑誌. (1992)

    • Related Report
      1991 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi