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SURGICAL TREATMENT OF ATRIAL FIBRILLATION-Evaluation of card iac and hemodynamic effects for atrial isolation procedure

Research Project

Project/Area Number 02807129
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionNippon Medical School

Principal Investigator

IKESHITA Masatoshi  Nippon Medical School Thorac. Surg. AsIst. Prof., 医学部, 助教授 (20089725)

Co-Investigator(Kenkyū-buntansha) UTSUNOMIYA Hidetoshi  Nippon Medical School Thorac. Surg. Regident, 医学部, 助手 (70176709)
MATAUYAMA Yuzuru  Nippon Medical School Thorac. Surg. Regident, 医学部, 助手 (50165924)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsatrial fibrillation / atrial isolation / atrial septal defect / 心房細胞 / 血栓塞栓症 / 右房隔離術 / 圧容積曲線
Research Abstract

Atrial fibrillation is the most common arrhythmia noted in clinical practice. Three detrimental sequelae result from the development of atrial fibrillation: 1)an irregular heartbeat, 2)impaired cardiac hemodynamics, primarily because of loss of the synchronous atrial kick, and 3)an increased vulnerability to thromboembolism. Patients with chronic atrial fibrillation will experience an associated thromboembolic epithod. In 1988, Harada developped right atria isolation procedure, that has electrophysiologic effects of isolating the right atrium with the origin of atrial fibrillation while preserving normal function and continuity of the sinoatrial node with the remainder of the heart.
Purpose of this study is to evaluate the cardiac function and hemodynamic effects, and apply this procedure to the patients with atrial fibrillation safely. Postopeartive cardiac and hemodynamic performance from some parameter of mean atria pressure, stroke volume index, left atrial pressure, right atrial pressure and Emax does not show significant changes for preoperative performance, and remained within normal limit. From these results, this procedure was applied two patients with atrial fibrillation and atrial septal defect. Postoperative normal sinus rhythm maintained for 10 months with disappearing atrial fibrillation. We conclude that the purpose of this study was achieved from these results.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 庄司 佑、池下 正敏: "不整脈の外科治療" 胸部外科. 42. 655-664 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 池下 正敏: "心臓外科領域における不整脈治療の動向" 臨床胸部外科. 12. 9-17 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hioki M,et al: "Successful combined operation for mitral steno sis and atrial fibrillation." Ann Thorac Surg.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 師田 哲郎ほか: "拍動流逆行性冠潅流法による心筋保護法の比較検討-Emaxを用いた保護効果の評価" 日本胸部外科学会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shoji T, Ikeshita M: "Surgical treatment of tachyarrhythmias" Jpn J Thorac Surg. 42. 655-664 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shoji T, Ikeshita M: "The trend and view of arrhythmia treatment in the field of cardiac surgery" JATS. 12. 9-17 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hioki M, et al: "Successful combined operation for mitral stenosis and atrial fibrillation" Ann Thorac Surg.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Morota T, et al: "Myocardial protection of pulsatile retrogr ade coronary sinus perfusion-Using Emax for left ventricular performance"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 池下 正敏: "心臓外科領域における不整脈治療の動向" 臨床胸部外科. 12(20). 9-17 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 池下 正敏: "心房細動の外科治療ー心房隔離術の心機能におよぼす影響について" 第44回 日本胸部外科学会総会. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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