| Project/Area Number |
02807141
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
SHIMAYA Masataka Nara Medical University Orthopedic Surgery Research Associate, 医学部, 助手 (30201552)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAI Susumu Nara Medical University Orthopedic Surgery Professor, 医学部, 教授 (10075088)
尾崎 二郎 奈良県立医科大学, 医学部, 講師 (50152468)
富田 直秀 奈良県立医科大学, 医学部, 大学院生
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | percutaneous device / artificial organ / skeletal extension / サイボーグ / 感染 / コラ-ゲン / 生体材料 / ポリマ- |
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| Research Abstract |
Some percutaneous devices are currently in clinical use such as bone-anchored hearing aid and CAPD catheter. However, in the case of skeletal extension, stronger connection between the device and skin is required, because higher force is applied to the interface. Although hydroxy apatite and our collagen immobilized surface showed good affinity with skin, the adhesive strength is not sufficient for the skeletal extension. Once the exfoliation occurs at the interface, the material surface cannot contact directory to the skin. This result suggests that more strong mechanical connection should be concerned with. An obstacle for the mechanical connection is the skin tissue which is continuously changing itself. Our new approach using the in-situtreatment of skin by glutaraldehyde fluid shows a possibility to get sufficient connective strength.
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