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Study on pathogenesis of urolithiasis with special reference to oxalate handling in biomembranes

Research Project

Project/Area Number 02807148
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionMie University

Principal Investigator

KAWAMURA Juichi  Mie University School of Medicine, Department of Urology, Professor, 医学部, 教授 (70026839)

Co-Investigator(Kenkyū-buntansha) YAMAKAWA Kensuke  Mie University School of Medicine, Department of Urology, assistant, 医学部附属病院, 助手 (00230326)
YANAGAWA Makoto  Mie University School of Medicine, Department of Urology, Lecturer, 医学部附属病院, 講師 (50174537)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsOxalate / Red Blood Cell Membrane / Oxalate Influx Rate / Renal Proximal Tubule / Brush Border and Basolateral Membrane Vesicles / Intestinal Epithelial Membrane Vesicles / Sodium-Oxalate Cotransport System / Oxalate : Bicarbonate Exchange System / 輸送系 / 赤血球 / 小腸 / 腎
Research Abstract

In this study we investigated mechanisms of oxalate transport in red blood cell membrane, intestinal and renal epithelial membranes which relate to oxalate absorption and excretion.
1. Oxalate influx rate in red blood cell membrane increased in calcium oxalate stone formers compared to that in healthy controls. This influx was inhibited by an inhibitor of anion exchange system such as DIDS.
2. There are oxalate : OH^- exchange and oxalate : HCO_3^- exchange systems both in the brush border membrane vesicles of the intraluminal side and in the basolateral membrane vesicles of the contraluminal side, in the renal proximal tubule Oxalate : OH^- exchange system shares the common transport pathway with oxalate : HCO_3^- exchange system.
3. Oxalate absorption is accelerated by an increment of sodium concentration in the intestinal epithelial cells, suggesting the existence of sodium-oxalate cotransport system in the intestine. This result coincides with the fact that urinary oxalate excretion is exaggerated by adding sodium chloride during oxalate loading test.
An increased oxalate influx rate in red blood cell membrane in calcium oxalate stone formers may share the common abnormality in biomembrane with the intestinal epithelium where oxalate absorption increases and with the renal epithelium where oxalate excretion increases.
Further investigations are required to analyse an abnormal transporter of oxalate within cells in calcium oxalate stone formers.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Yamakawa,K: "Oxalate:OH exchange across rat renal cortical brush border membrane" Kidney International. 37. 1105-1112 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yanagawa,M: "The formation of oxalate from glycolate in rat and human liver" Biochimica et Biophysica Acta. 1036. 24-33 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 加藤 貴裕: "蓚酸カルシウム結石患者赤血球膜におけるoxalate influx rateの検討" 泌尿紀要. 37. 837-844 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山川 謙輔: "尿路結石症:基礎と臨床ー促進物質としての蓚漣の役割" 泌尿紀要. 37. 1111-1114 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 川村 寿一: "腎尿管結石モデル" 腎と透析臨時増刊. 520-524 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 川村 寿一: "Annual Review腎臓1990(IV.間質・尿細管。尿細管蓚酸代謝、編者:越川昭三他)" 中外医学社, 298 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 川村 寿一: "Epidemiology of renal stone disease in Japan.In:Geographical nephrology(Eds by Mochizuki M et al)" International Center for Medical Research(ICMR) Kobe Univ Sch Med,Japan, 226 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kensuke Yamakawa & Juichi Kawamura : Oxalate: "Ohexchange across rat renal cortical brush border membrane." Kidney International. 37. 1105-1112 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Makoto Yanagawa et al.: "The formation of oxalate from glycolate in rat and human liver." Biochimica et Biophysica Acta.1036. 24-33 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Juichi Kawamura & Kensuke Yamakawa: "Oxalate metabolism in the renal tubule. (Eds. by S. Koshikawa et al.)" Annual Review of Kidney 1990. Chugai Igakusha. 122-128 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kato T. et al: "Oxalate influx rate in red blood cells in calcium oxalate nephrolithiasis." Acta urlo. Jpn.37. 837-844 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamakawa K. et al: "Oxalate as a promoter in calcium oxalate nephrolithiasis." Acta Urlo. Jpn.37. 1111-1114 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kawamura J. et al: "Calcium oxalate urolithiasis in the rat." Kidney & Dialysis 1991. Supplement. 520-524 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kawamura J & Yoshida O: "Epidemiology of renal stone diseases in Japan." Geographical nephrology. International Center for Medical Research (ICMR). 193-208 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamakawa,K: "Oxalate:OH exchange across rat renal cortical brush border membrane" Kidney International. 37. 1105-1112 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yanagawa,M: "The formation of oxalate from glycolate in rat and human liver" Biochimica et Biophysica Acta. 1036. 24-33 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 加藤 貴裕: "蓚酸カルシウム結石患者赤血球膜におけるoxalate influx rateの検討" 泌尿紀要. 37. 837-844 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山川 謙輔: "尿路結石症:基礎と臨床一促進物質としての蓚酸の役割" 泌尿紀要. 37. 1111-1114 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 川村 寿一: "腎尿管結石モデル" 腎と透析 臨時増刊. 520-524 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 越川 昭三 他編,川村 寿一: "Annual Review腎臓1990(IV.問質・尿細管。尿細管蓚酸代謝)" 中外医学社, 298 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Mochizuki M et al (Ed.),川村 寿一: "Geographical nephrology,(Epidemiology of renal stone disease in Japan.)" International Center for Medical Research(ICMR)Kobe Univ Sch Med,Japan, 226 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 加藤 貴裕ほか: "蓚酸カルシウム結石患者の赤血球膜におけるoxalate influxrateの検討" 泌尿器科紀要.

    • Related Report
      1990 Annual Research Report
  • [Publications] 山川 謙輔ほか: "尿路結石症・基礎と臨床ー促進物質としての蓚酸の役割ー" 泌尿器科紀要.

    • Related Report
      1990 Annual Research Report
  • [Publications] 川村 寿一・山川 謙輔: "尿細管蓚酸代謝" Annual Review腎臓1990.(越川昭三他編集),中外医学社. 122-128 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yamakawa K & Kawamura J: "Oxalate:OH exchange across rat renal cortical brush border membrane." Kidney International. 37. 1105-1112 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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