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ALVEOLAR BONE DYNAMICS IN THE RATS WITH AN EXPERIMENTAL OSTEOPOROSIS

Research Project

Project/Area Number 02807178
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 補綴理工系歯学
Research InstitutionKAGOSHIMA UNIVERSITY DENTAL SCHOOL

Principal Investigator

NAGAOKA Eiichi  KAGOSHIMA UNIVERSITY DENTAL SCHOOL, THE SECOND DEPARTMENT OF PROSTHETIC DENTISTRY, PROFESSOR, 歯学部, 教授 (00028812)

Co-Investigator(Kenkyū-buntansha) KOHNO Hiroshi  KAGOSHIMA UNIVERSITY DENTAL SCHOOL, THE SECOND DEPARTMENT OF PROSTHETIC DENTISTR, 歯学部, 助手 (00234708)
KAMASHITA Yuji  KAGOSHIMA UNIVERSITY DENTAL SCHOOL, THE SECOND DEPARTMENT OF PROSTHETIC DENTISTR, 歯学部, 助手 (90224641)
SAKODA Satoshi  KAGOSHIMA UNIVERSITY DENTAL SCHOOL, THE SECOND DEPARTMENT OF PROSTHETIC DENTISTR, 歯学部, 助手 (00235235)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
Keywordsexperimental osteoporosis / low-Ca diet / low-normal diet / femur / mandible / 60-week-old rat / fluorescence microscopy / コンタクトマイクロラジオグラム / 骨粗鬆症 / 組織標本(脱灰、非脱灰) / Ca量(血中、骨中) / 低カルシュ-ム食 / ラベリング法 / ウィスタ-系ラット
Research Abstract

We reported on the results of the experimental osteoporosis which the low-calcium diets brought about the condition of osteoporosis in the mandible as well as in the femur of the 8-week- and 44-week-old rats. However the degree of those influence was stronger in the 8-week-old rats than in the 44-week-old rats.
The purpose of this study was to elucidate whether the experimental osteoporosis is induced in the 60-week-old rats as well as 8-week- and 44-week-old rats fed by low calcium diets, and to know the bone dynamics after the diets were changed from the low-calcium contents. dynamics after the diets were changed from the low-calcium contents to the normal calcium contents.
The rats were divided to three groups by the feeding methods. In the one ( control group ) the rats were given the normal diets for 16 week, in the another one ( low-Ca group ) the rats were given the low-calcium diets for 16 weeks, and in the third one ( low-normal group ) the rats were given the normal diets for 4 weeks after the low-calcium diets for 12 weeks. The decalcified sections of the femoral bone and the mandibular bone, which were labeled by the tetracycline, we prepared to observe by the contactmicroradiogram and the fluorescent microscopy. The weight of bone laid in ashes was measured. In this time the calcium level in the blood and in the bone both of femur and mandible were unable to be measured because of the disturbance of the tetracycline.
In the low-Ca group the experimental osteoporosis was induced and the bone mass was decreased. In the low-normal group the reduction of bone mass induced during the low-calcium diets could be recovered under the normal diets.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 迫田 敏、鎌下 祐次,河野 弘、長岡 英一: "実験的骨粗鬆症に関する研究 第3報老齢ラットの下顎骨ならびに大腿骨に対する食餌の影響" 日本補綴歯科学会雑誌. 37. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sakoda Satoshi, Kamashita Yuji, Kohno Hiroshi, Nagaoka Eiichi: "An experimental osteoporosis - The effect of the different feeding on the mandible and the femur in the old rats -" J Jpn Prothodont Soc. 37-5. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 平井 直: "実験的骨粗鬆症に関する研究 第1報 Ca調整飼料によるラットの骨ならびに血中Caの測定" 日本補綴歯科学会雑誌. 34(83回特別号). 188 (1901)

    • Related Report
      1991 Annual Research Report
  • [Publications] 迫田 敏: "実験的骨粗鬆症に関する研究 第2報 成熟ラットの下顎骨ならびに大腿骨に対するCa調整飼料の影響" 日本口腔インブラント学会誌 第20回日本口腔インブラント学会総会講演要旨. 4. 79 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 迫田 敏: "実験的骨粗鬆症に関する研究第2報 成熟ラットの下顎骨ならびに大腿骨に対するCa調整飼料の影響" 日本口腔インプラント学会総会20週年記念講演会抄録集. 抄録集. 60 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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