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Information Exchange on Cancer Research with North American Countries.

Research Project

Project/Area Number 03042013
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionInstitute of Medical Science, University of Tokyo

Principal Investigator

YAMAGUCHI Nobuo  Institute of Medical Science, University of Tokyo, Professor, 医科学研究所, 教授 (90012723)

Co-Investigator(Kenkyū-buntansha) HAMADA Hirofumi  Cancer Chemotherapy Center, 癌化学療法センター, 部長 (00189614)
KOUNO Kimitoshi  Oita Medical University, 助教授 (00153479)
TSUKUMA Hideaki  Center for Adult Diseases, Osaka, 主幹
TAKAHASHI Takashi  Aichi Cancer Center Reserach Institute, 研究所, 室長 (50231395)
TANIGUCHI Naoyuki  School of Medicine, Osaka University, 医学部, 教授 (90002188)
YOSHIKI Takashi  School of Medicine, Hokkaido University, 医学部, 教授 (60220612)
IKEUCHI Taturou  Medical Research Institute, Tokyo Medical and Dental University, 難治疾患研究所, 助教授 (90041839)
YOSHIDA Mituaki  Institute of Medical Science, University of Tokyo, 医科学研究所, 教授 (80012607)
ISHIBASHI Masahide  Aichi Cancer Center Research Institute, 部長 (70029776)
SIBUYA Masabumi  Institute of Medical Science, University of Tokyo, 医科学研究所, 教授 (10107427)
KATAOKA Tooru  School of Medicine, Kobe University, 医学部, 教授 (40144472)
CHIDA Kazuhiro  Insititute of Medical Science, University of Tokyo, 医科学研究所, 助手 (00192188)
NODA Tetuo  Cancer Institute, 癌研究所, 部長 (10183550)
FUJISAWA Jun-ichi  Institute of Medical Science, University of Tokyo, 医科学研究所, 助教授 (40181341)
NAKABEPPU Yuusaku  Medical Institute of Bioregulation, Kyusyu University, 生体防御医学研究所, 助手 (30180350)
TAKAHASHI Rei  Faculty of Medicine, Kyoto University, 医学部, 助教授 (60144565)
SASAKI Takuya  School of Medicine, Kobe University, 医学部, 助手 (40241278)
阿部 周一  北海道大学, 理学部, 助教授 (80125278)
根本 信雄  癌研究所, 主任研究員 (10085631)
菅村 和夫  東北大学, 医学部, 教授 (20117360)
須川 秀夫  京都大学, 医学部, 助手 (70162857)
田中 伸之  大阪大学, 細胞生体工学センター, 助手 (80222115)
内海 博司  京都大学, 放射線生物研究センター, 助教授 (20025646)
今井 高志  癌研究所, 室長 (50183009)
小幡 裕一  愛知がんセンター, 室長 (30177290)
加藤 勝  国立がんセンター, 研究員 (50233820)
伊藤 嘉明  京都大学, ウイルス研究所, 教授 (80004612)
森井 成人  京都大学, 医学部, 講師 (80220036)
平井 久丸  東京大学, 医学部, 講師 (90181130)
武部 啓  京都大学, 医学部, 教授 (10028318)
伊庭 英夫  東京大学, 医科学研究所, 助教授 (60111449)
清木 元治  金沢大学, がん研究所, 教授 (10154634)
武市 紀年  北海道大学, 医学部, 助教授 (40002133)
石崎 寛治  京都大学, 放射線生物研究センター, 助教授 (70111987)
首藤 紘一  東京大学, 薬学部, 教授 (50012612)
菊池 章  神戸大学, 医学部, 助手 (10204827)
山口 政光  愛知県がんセンター研究所, 主任研究員 (00182460)
安本 茂  神奈川県立がんセンター, 研究所, 主任研究員 (00112342)
佐竹 正延  京都大学, ウイルス研究所, 助教授 (50178688)
山本 雅  東京大学, 医科学研究所, 教授 (40134621)
秋山 徹  大阪大学, 微生物病研究所, 助教授 (70150745)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥27,000,000 (Direct Cost: ¥27,000,000)
Fiscal Year 1993: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1992: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1991: ¥9,000,000 (Direct Cost: ¥9,000,000)
KeywordsInformation exchange / Oncogene / Tumor virus / Tumor promoter / Tumor suppressor gene / Cancer cells / Growth control / Transcriptional regulation / がん研究 / 研究交流 / 北米 / 研究室訪問 / 研究集会
Research Abstract

This research project is to exchange information between groups of high research activity in Japan and those in North American countries.
The research fields of this project were as follows.
1.Oncogene research
2.Viral Oncogenesis
3.Tumor promotion and suppression
4.Diagnostic techniques and cancer therapy
Under this program from 1991 to 1993 fiscal year, total 49 Japanese scientists were sent to United State of America and Canada to attend Annual Meeting on oncogene, Cancer Cell meeting, Keystone Symposia, Papillomavirus Workshop, Annual Meeting on AIDS and HTLV, AACR Special Conferences, Workshop on Biology of Lung Cancer, DNA tumor virus meeting, General Morters Cancer Foundation International Symposium, Cold Spring Harbor Meeting on Eukaryotic DNA Replication, FASEB Summer Research Conference, The Joint-Meeting of American Societies of Biochemistry, Molecular Biology, and Immunology, etc. and also visited universities and institutes to exchange information.
Scientists in Japan, which is geologically remote from developed countries, feel informational retardation. International co-operative studies in progress or in planning, need lively discussions on experimental arrangements.
Face-to-face discussions also facilitate international exchange of research materials. Therefore, this research grant contributed greatly not only for the development of the research of the Japanese grant recipients but also for the development of the research of those who came into touch with them.
The individual results under this program have been published in scientific journals, and a part of the information were also published on the "Bioscience News".

Report

(3 results)
  • 1993 Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Yamamoto,K.(Shibuya,M.): "Characterization of the promoter region of the human c-kit proto-oncogene" Jpn.J.Cancer Res.84. 1136-1144 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Gotoh,N.(Sibuya,M.): "Epidermal growth factor receptor-mutant lacking the autophosphorylation sites induces phosphorylation of Shc and association of Shc with Grb2/Ash,and retains mitogenic activity." Proc.Natl.Acad.,Sci.USA. 91. 167-171 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ookawa,K.(Takahashi,R.): "Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations." Oncogene. 8. 2175-2181 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Habuchi,T.(Takahashi,R.): "Metachronous multifocal development of urothelial cancers by intraluminal seeding." The Lancet. 1993. 1087-1088 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Habuchi,T.(Takahashi,R.): "Accumulated allelic losses in the development of invasive urothelial cancer." Int.J.Cancer. 53. 579-584 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takaishi,K.(Sasaki,T.): "Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility." Oncogene. 9. 273-279 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki,T.(Fujisawa,J.): "A trans-activator tax of human T-cell leukemia virus type 1 binds to NF-κB p50 and serum response factor(SRF)and associates with enhancer DNAs of the NF-κB site and CArG box." Oncogene. 8. 2391-2397 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tanimura,A.(Fujisawa,J.): "A new regulatory element that augments for the tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins." J.Virol.67. 5375-5382 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yamamoto, K. (Shibuya, M.): "Characterization of the promoter region of the human c-kit proto-oncogene." Jpn. J. Cancer Res.84. 1136-1144 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Gotoh, N. (Sibuya, M.): "Epidermal growth factor receptor-mutant lacking the autophosphorylation sites induces phosphorylation of Shc and association of Shc with Grb2/Ash, and retains mitogenic activity." Proc.Natl.Acad.Sci.USA. 91. 167-171 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ookawa, K. (Takahashi, R.): "Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations." Oncogene. 8. 2175-2181 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Habuchi, T. (Takahashi, R.): "Metachronous multifocal development of urothelial cancers by intraluminal seeding." The Lancet. 1993. 1087-1088 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Habuchi, T. (Takahashi, R.): "Accumulated allelic losses in the development of invasive urothelial cancer." Int. J. Cancer. 53. 579-584 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takaishi, K. (Sasaki, T.): "Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility." Oncogene. 9. 273-279 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki, T. (Fujisawa, J.): "A transactivator tax of human T-cell leukemia virus type 1 binds to NF-kappaB p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappaB site and CArG box." Oncogene. 8. 2391-2397 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tanimura, A. (Fujisawa, J.): "A new regulatory element that augments for the tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins." J.Virol.67. 5375-5382 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] NISHIGORI,C.: "Accelerated appearance of skin tumors in hairless mice by repeated UV irr-adiation with initial intense exposure and characterization of the tumors." Jpn.J.Cancer Res.83. 1172-1178 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] GOTOH,N.: "A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor." Biochem.Biophys.Res.Commun. 186. 768-774 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] SUZUKI,T.: "A transactivator Tax of human T-cell leukemia virus type 1(HTLV-1)interacts with cAMP-responsive element (CRE)binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1." Proc.Natl.Acad.Aci.USA. 90.

    • Related Report
      1992 Annual Research Report
  • [Publications] HANAZONO,Y.: "c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3." EMBO J.

    • Related Report
      1992 Annual Research Report
  • [Publications] YAMAMOTO,M.: "ADP-ribosylation of rhoA gene product y botulinum C3 exoenzyme accumulates Swiss 3T3 cells in the G1 Phase of the cell cycle." Oncogene.

    • Related Report
      1992 Annual Research Report
  • [Publications] SATAKE,M.: "Differential expression of subspecies of polyomavirus and murine leukemia virus enhancer core binding portein,PEBP2 in various hematopoietic cells." Jpn.J.Cancer Res.83. 714-722 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 阿部 周一: "上皮性分化を示す骨・軟部悪性腫瘍の染色体異常" 病理と臨床. 10. 1385-1390 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] OBATA,Y.: "Mouse TL antigen acts as a tumor specific transplantation antigen:transgenic approach." Mouse Molecular Genetics. 155 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Int.J.Radiat.Bio.: "Intrinsic radiosensitivity and PLD repair in osteosarcoma cell lines." Sugimoto,M.62. 469-474 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] SUGAWA,H.: "Production and porperties of novel human thyroid cancer specific monoclonal antibodies." Biochem.Biophys.Res.Commun. 187. 404-412 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] HARADA,H.: "Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2." Science.

    • Related Report
      1992 Annual Research Report
  • [Publications] NEMOTO,N: "Cell-density dependent expression of Cypla-2 gene in monolayercultured adult mouse hepatocytes." Jpn.J.Cancer Res.

    • Related Report
      1992 Annual Research Report
  • [Publications] TAKESHITA,T.: "Cloning of the γ chain of the human IL-2 receptor." Science. 257. 379-382 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Akiyama,T.: "The transforming potetial of the c-erbB-e protein is regulated by its autophosphorylation at the carboxy-terminal domain." Mol.Cell.Biol.11. 833-842 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Okada,M.: "A protein-tyrosine kinase involved in regulation of src-family kinases" J.Biol.Chem.

    • Related Report
      1991 Annual Research Report
  • [Publications] 堀越 正美: "真核細胞のmRNA転写調節ー最近の動向" 蛋白質・核酸・酵素.

    • Related Report
      1991 Annual Research Report
  • [Publications] Sugimoto,K.: "Mutations of the p53 gene in lymphoid leukemia." Blood. 77. 1153-1156 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yasumoto,S.: "Epidermal growth factor (EGF) elicits down-regulation of human papillomavirus type 16 (HPV-16) E6/E7 mRNA at the transcriptional level in an EGF-stimulated human keratinocytes cell line:Functional role of EGF-responsive silencer in the HPV-16 long control region." J.Virol.65. 2000-2009 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Fujisawa,J.: "The indirect association of human T-cell leukemia virus tax protein with DNA results in transcriptional activation." J.Virology. 65. 4525-4528 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yamaguchi,M.: "Repression of the Drosophila proliferating cell nuclear antigen gene promoter by zerknullt protein." Mol.Cell.Biol.11. 4909-4917 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kikuchi,A.: "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21." Oncogene.

    • Related Report
      1991 Annual Research Report
  • [Publications] Fujimori,S.: "Enantio-and meso-Oligo-deoxy ribonucleotides." Nucleic Acid Res.143-144 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Wagata,T.: "Deletion of 17p and amplification of the int-2 gene in esophageal carcinomas." Cancer Res.51. 2113-2117 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sato,H.: "Expression of genes encoding type IV collagen-degrading metallopoteinases and tissue inhibitor of metalloproteinases in various human tumor cells." Oncogene. 6.

    • Related Report
      1991 Annual Research Report
  • [Publications] Nagayama,S.: "Occurrence of auto-immune antibodies to liver microsomal proteins in association with fulminant hepatitis in the LEC strain of rats." Biochem.Biophys.Res.Commun.179. 1139-1140 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Suzuki,T.: "Difference in transcriptional regulatory function between c-Fos and Fra-2." Nucleic Acid Research. 19. 5537-5542 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2020-04-13  

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