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Development of micro-biosensors

Research Project

Project/Area Number 03044047
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionUniversity of Tokyo

Principal Investigator

KARUBE Isao  Research Center for Advanced Science and Technology University of Tokyo, 先端科学技術研究センター, 教授 (50089827)

Co-Investigator(Kenkyū-buntansha) ROLF Schmid  ブランシュワイク工科大学, 教授
JEANーLOUIS M  ペルピニアン大学, 講師
MAURICE Comt  ポール, サバチェ大学, 教授
PIERRE Coule  リヨン大学, 教授
DANIEL Thoma  コンピュータ工科大学, 教授
YOKOYAMA Kenji  Research Center for Advanced Science and Tehcnology University of Tokyo, 先端科学技術研究センター, 客員研究員 (80242121)
SEKI Atsushi  Faculty of Engineering, Soka University, 工学部, 助手 (70226629)
SUZUKI Masayasu  Research Center for Advanced Science and Technology University of Tokyo, 先端科学技術研究センター, 助手 (70226554)
KUBO Izumi  Faculty of Engineering, Soka University, 工学部, 助教授 (40214986)
TAMIYA Eiichi  Research Center for Advanced Science and Tehcnology University of Tokyo, 先端科学技術研究センター, 助教授 (60179893)
SCHMID Rolf  Braunschweig Institute Technology
MARTY Jean-Louis  Perpignan University
COMTAT Maurice  Paul Sabatier University
COULET Pierre  Lyon University
THOMAS Daniel  Compiegne University
Project Period (FY) 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1991: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsBiosensor / Environmental Analyses / Micro-biosensor / Enzyme sensor / Clinical testing / immobilized enzyme
Research Abstract

Biosensor is a novel analytical system which is available for clinical testing, industrial process control and environmental monitoring. Recently Prof. Karube's group has succeeded miniaturization and mass production of biosensors using silicon fabrication technology. This project aims at promotion of cooperational researches with French and Germany groups. We especially focus on development of micro-biosensors and their applications.
Prof. Tamiya stayed at Braunschweig Institute Technology and investigated odorant sensor using piezoelectric crystal coated with artificial lipid which newly was synthesized by prof. Schmidt group. Dr. Tamiya examined possiblity of stable odorant sensor. He discussed with prof. Marty. Perpignan Univ. about pesticide sensor. Prof. Marty's doctor student will stay for 1 and half year at Prof. Karube's lab to promote this project.
Dr. Yokoyama stayed at Prof. Comtat lab in Paul Sabatier University. Prof. Comtat has studied electrochemical NAD recyclng system a … More nd applied to biosensors using dehydrogenases. Dr. Yokoyama fabricated microbiosensors for determination of lactic acid using a miro Pt electrode immobilized lactate dehydrogenased and diaphorase. This ia one of actual products supported by this cooperational project.
Dr. Suzuki investigated researches about immobilization of enzymes for integration of micro-biosensors. Photocrosslinking polymer used in prof. Karube lab is useful for immobilization of enzymes on multi-printed electrodes which are produced by Prof. Schmidt lab in Braunschweig Institute Technology. Prof. Coulet in Lyon Univ. used a simple immobilization method. Only immersion in enzyme solution gives covalent bonding between membrane and enzyme. Prof. Kubo discussed with Prof. Thomas in Compiegne Univ. who was interested in sensors for control of bioreactors. Minituarized and integrated bosensors are powerful tools for monitoring of bioreactors. Prof. Kubo visited Prof. Marty lab in Perpignan Univ. and discussed about biosensors for environmental analyses. Carbon dioxide sensor is requried for fabrication of French pecicide sensors. Japanese group supply carbon dioxide sensors to French side in order to support French group.
Dr. Seki Madea colloboration with Prof. Coulet in Lyon University. He fabricated ISFET biosensor based on LB membrane. ISFET is one of useful transducers for micro-biosensors. LB techniques may be powerful tool for immobilization of biomaterials.
Prof. Sato and Kajiwara also took parts in this project. They visited Compiegne Univ. Paul Sabatie Univ. and Perpignan Univ. in order to investigate researches about novel biosensors based on thermal detection.
Prof. Karube discussed with Prof. Thomas and Prof. Schmidt about promotion of this project. They concluded that this project should be continued for making fruitful results. Less

Report

(1 results)
  • 1991 Final Research Report Summary
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] S.M.Chang,Y.Iwasaki,M.Suzuki,E.Tamiya,I.Karube: "Detection of odorants using an array of piezoolectric crystals and neural-network pattern recognition" Anal.Chim.Acta. 249. 323-329 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] E.Tamiya,Y.Sugiura,S.Mizoshita,K.Nakajima,A.Akiyama,I.Karube: "Ultramicro-acetylcholine sensor based on an enzyme-modrfied carbon fibre electodl" Anal.Chim.Acta. 251. 129-134 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S.Lee,M.Suzuki,E.Tamiya,I.Karube: "Microbial detection of toxic compounds utilizing recombinant DNA technology and biolaiuinesceuce" Anal.Chim.Acta. 244. 201-206 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Yokoyama,E.Tamiya,I.Karube: "Amperometric glucose sensor using silicon oxide deposited gold electrodes" Electroanalysis. 3. 469-475 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Izumi Kubo,Masako Inagawa,Takako Sugawara,Yoshiko Arikawa,Isao Karube: "Phosphate sensor composed from immobilized pyruvate oxidase and an oxygen electrode" Anal.Letters. 24. 1711-1727 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Atsushi Seki,Eiichi Tamiya,Isao Karube: "Amplification immunoassay for the determination of Hepatitis B surface autigen" Appl.Biochem.Biotech.27. 259-265 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 軽部 征夫: "バイオのはなし" 日本実業出版社, 241 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 軽部 征夫: "バイオエレクトロニクスの未来" NTT出版, 226 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. M. Chang, Y. Iwasaki, M. Suzuki, E. Tamiya, I. Karube: "Detection of odorants using an array of piezoelectric crystals and neural-network pattern recognition" Anal. Chim. Acta. 249. 323-329 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] E. Tamiya, Y. Sugiura, S. Mizoshita, K. Nakajima, A. Akiyama, I. Karube: "Ultramicro-acetylcholine sensor based on an enzyme-modified carbon fibre electrode" Anal. Chim. Acta. 251. 129-134 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Lee, M. Suzuki, E. Tamiya, I. Karube: "Microbial detection of toxic compounds utilizing recombinant DNA technology and bioluminescnece" Anal. Chim. Acta. 244. 201-206 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yokoyama, E. Tamiya, I. Karube: "Amperometric glucose sensor using silicon oxide deposited gold electrodes" Electroanalysis. 3. 469-475 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I. Kubo, M. Inagawa, T. Sugawara, Y. Arikawa, I. Karube: "Phosphate sensor composed from immobilized pyruvate oxidase and an oxygen electrode" Anal. Letters. 24. 1711-1727 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I. Karube: Nihon Jitsugyo Pub.BAIO NO HNASHI (in Japanese), 241 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I. Karube: NTT. Pub.Baioerekutoronikusu no Mirai (in Japanese), 226 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary

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Published: 1991-04-01   Modified: 2017-03-29  

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