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Basic study on development of medicines from tropical plants

Research Project

Project/Area Number 03045017
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research InstitutionChiba University

Principal Investigator

HIROSE Seiyu  Chiba University, Professor, 薬学部, 教授 (40009163)

Co-Investigator(Kenkyū-buntansha) BAVOVADA Rap  チュラロンコン大学, 薬学部, 準教授
SAIFAH Ekari  チュラロンコン大学, 薬学部, 準教授
KULVANICH Po  チュラロンコン大学, 薬学部, 助教授
NIMMANNIT Ub  チュラロンコン大学, 薬学部, 準教授
TANTISIRA Ma  チュラロンコン大学, 薬学部, 助教授
TONGROACH Pa  チュラロンコン大学, 薬学部, 準教授
ATMIYANAN Preeya  Chulalongkorn University, 薬学部, 準教授
PUMMANGURA S  チュラロンコン大学, 薬学部, 準教授
LIPIPAN Vimo  チュラロンコン大学, 薬学部, 準教授
PRAMYOTHIN P  チュラロンコン大学, 薬学部, 準教授
PONGLUX Dhavadee  Chulalongkorn University, 薬学部, 準教授
ISHII Itsuko  Chiba University, 薬学部, 助手 (00202929)
YAMAGUCHI Akihito  Chiba University, 薬学部, 助教授 (60114336)
SATOH Tetsuo  Chiba University, 薬学部, 教授 (60092061)
YAMAMOTO Keiji  Chiba University, 薬学部, 教授 (50110341)
SAWAI Tetsuo  Chiba University, 薬学部, 教授 (70009174)
WATANABE Kazuo  Chiba University, 薬学部, 教授 (80019124)
YAMAGAKI Mikio  Chiba University, 薬学部, 教授 (70089598)
MURAKOSHI Isamu  Chiba University, 薬学部, 教授 (30009162)
SAKAI Shin-ichiro  Chiba University, 薬学部, 教授 (20009161)
PORNPEN Pramyothin  Chulalongkorn University
RAPEPOL Bavovada  Chulalongkorn University
UBONTHIP Nimmannit  Chulalongkorn University
VIMOLMAS Lipipan  Chulalongkorn University
EKARIN Saifah  Chulalongkorn University
PUMMANGURA Sunibhond  Chulalongkorn University
TANTISIRA Mayuree H.  Chulalongkorn University
PAVICHI Tongroach  Chulalongkorn University
POJ Kulvanich  Chulalongkorn University
U Nimmannit  チュラロンコン大学, 薬学部, 準教授
R Bavovada  チュラロンコン大学, 薬学部, 準教授
P Tongroach  チュラロンコン大学, 薬学部, 準教授
P Kulvanich  チュラロンコン大学, 薬学部, 助教授
M Tantisira  チュラロンコン大学, 薬学部, 助教授
S Pummangura  チュラロンコン大学, 薬学部, 準教授
P Atmiyanan  チュラロンコン大学, 薬学部, 準教授
D Pouglux  チュラロンコン大学, 薬学部, 準教授
SAISORN B.  チュラロンコン大学, 薬学部, 準教授
POUGLUX D.  チュラロンコン大学, 薬学部, 準教授
石井 永  千葉大学, 薬学部, 教授 (70009166)
日野 亨  千葉大学, 薬学部, 教授 (10009160)
TANTISIRA M.  チュラロンコン大学, 薬学部, 準教授
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1991: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsTropical and medical plants / Development of medicines / Compounds of medical plants / Pharmacological effect / Biological active substance / Antimicrobial activity / Pharmaceuticals / Alkaloid / 医薬品開発の基礎研究 / 有効成分の分離方法 / 薬用植物成分の化学構造 / 生物活性物質の探索
Research Abstract

The Faculty of Pharmaceutical Sciences of Chiba University concluded the inter-faculty agreement for research cooperation programs with the Faculty of Pharmaceutical Sciences, Chulalongkorn University in Thailand in 1990. On the basis of this agreement, the cooperative research for creating new medicines from tropical plants was organized. This cooperation was also expected to improve the development of the pharmaceutical sciences in Thailand.
During the cooperative period (April 1991 to March 1994), Chiba University sent nine faculty staffs to Chulalongkorn University and nine staffs of Chulalongkorn University were invited to Chiba University. Specialities of the participates in this research project are organic chemistry, pharmacology, pharmacognosy, pharmaceutical technology, biochemistry, microbiology and toxicology. According to the general planning, three staffs per year visited Thailand and carried out a field study of medicinal plants growing wild in the north mountain area of Thailand. This survey was realized by the assistance of the staffs of Chulalongorn University and Chiang Mai University. The visiting staffs also held workshops for presenting professional information and new experimental techniques of each research field at Chulalonkorn University. On the other hand, three staffs of Chulalongkorn University per year visited Japan and participated in the research project carried out in a corresponding laboratory of Chiba University. The invited researchers also held the seminar for presenting their research activities in Thailand. These cooperative investigations have resulted in a finding of some interesting materials as to the candidates for new medicines from medicinal plants.
Preliminary reports of these results have been published.

Report

(3 results)
  • 1993 Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] S.Sakai,and M.Suttajit,et al.: "The Structure of Garcinone E." Chem.Pharm.Bull.41. 958-960 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] C.Phisalaphong,H.Takayama,and S.Sakai: "A First Synthesis of 20-Hydroxydihydro rankinidine from Gelsemium elegans." Tetrahedron Lett.34. 4035-4038 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Takayama,S.Sakai,et al.: "Application of Tungstatecatalyzed Oxidation in the Gelsemium Alkaloid Synthesis." Natural Product Lett.2. 271-276 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Seki,H.Takayama,N.Aimi,S.Sakai,D.Ponglux: "A Nuclear Magnetic Resonance Study on the Eleven Stereoisomers of Heteroyohimbine-Type" Chem.Pharm.Bull.41. 2077-2086 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Subhadhirasakul,N.Aimi,H.Takayama,D.Ponglux,S.Sakai: "Hunterioside,First Biose Bound Monoterpenoid Indole Alkaloid from Huntera zeylanica." Chem.Pharm.Bull.42(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] D.Ponglux,S.Sakai,et al.: "A New Indole Alkaloid,7-alpha-Hydroxy-7H-mitragynine,from Mitragyna speciosa in Thailand." Planta Medica. 60(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] I.Murakoshi,T.Sekine,K.Maeshima,F.Ikegami,K.Yoshinaga,Y.Fujii,and S.Okonogi: "Absolute Configuration of L-Methionine Sulfoximine as a Toxic Principle in Cnestis palala MERR." Chem.Pharm.Bull.41(2). 388-390 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Sekine,Y.Arai,F.Ikegami,Y.Fujii,S.Shindo,T.Yanagisawa,Y.Ishida,S.Okonogi,and I.Murakoshi: "Isolation of Camelliaside C from Tea Seed Cake and Inhibitory Effects of Its Derivatives on Arachidonate 5-Lipoxygenase" Chem.Pharm.Bull.41(6). 1185-1187 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] I.Murakoshi,T.Sekine,H.Suzuki,C.Ninomiya,K.Saito,S.Okonogi,and F.Ikegami: "Monolignan and Diterpene Glycosides from the Stems of Tinospora rumphii Boerl." Thai J.Pharm.Sci.17(1). 33-37 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Sekine,N.Fukasawa,K.Saito,F.Ikegami,S.Okonogi,and I.Murakoshi: "A New Monoterpenoidal Carboxaminde from the Seeds of Acacia concinna" Thai J.Pharm.Sci.(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] F.Ikegami,T.Sekine,O.Iijima,Y.Fujii,O.Okonogi,and I.Murakoshi: "Anti-Dermatophyte Activities of Tea Seed Cake and Pegu-catechu" Thai J.Pharm.Sci.(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] DHAVADEE PONGLUX: "STRUCTURES OF TWO NEW BITTER PRINCIPLES ISOLATED FROM A THAI MEDICINAL PLANT,VERNONIA" CHEM.PHARM.BULL.40. 553-555 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] HARUHIRO FUJIMOTO: "ISOLATION,IDENTIFICATION AND PHARMACOLOGICAL STUDIES ON THREE TOXIC METABOLITES FROM A MUSHROOM,HEBELOMA SPOLATUM" CHEM.PHARM.BULL.40. 869-872 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] NORIO AIMI: "SYNTHESIS OF LYAOSIDE,A PROTOTYPAL β-CARBOLINE GLUCO INDOLE ALKALODE IN RUBIACEOUS PLANTS" CHEM.PHARM.BULL.40. 2588-2590 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] SYUNJI HORIE: "EFECT OF HIRSUTNE,AN ANTIHYPERTENSIVE INDOLE ALKALOIDE FROM UNCARIA RHYNCHOPHYLLA,ON INTRCELLULAR CALCIUM IN RAT THORACIC AORTA" LIFE SCIENCES. 50. 491-498 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] ISAMU MURAKOSHI: "ABSOLUTE CONFIGURATION OF L-METHIONINE SULFOXIMINE AS A TOXIC PRINCIPLE IN CNFSTIS PALALA(LOUR.)MERR." THAIJ.PHARM.SCI.16. 149-162 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] HIROMITU TAKAYAMA: "THE FIRST AND BIOMIMETIC CONSTRUCTION OF THE 6 SKELTON OF GELSELEGINE-TYPE OXINDOLE ALKALOIDS" J.ORG.CHEM.57. 4583-4584 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] SATOSHI TAKAMATSU: "LUPIN ALKALOIDS FROM SOPHORA exigua" PHYTOCHEMISTRY. 30. 3793-3795 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] EMI OKUYAMA: "ANALGESIC PRINCIPLES FROM ARALIA CORDATA THUNB." CHEM.PHARM.BULL. 39. 405-407 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] MARIKO KITAJIMA: "STEREOSELECTIVE TRANSFORMATION OF AJMALINE INTO THREE MINOR GELSEMIUM ALKALOIDS.KOUMIDINE,19Z-ANIYDROVOBASINEDIOL AND N-DEMETHOXYRANKINIDINE AND THEIR ABSOLUTE CONFIGURATION" J.CHEM.SOC.PERKIN TRANS.I.1773-1779 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] SHINGO YANO: "Ca^<11>CHANNEL BLOCKING EFFECTS OF HIRSUTINE.AN INDOLE ALKALOID FROM UNCARIA GENUS.IN THE ISOLATED RAT AORTA." PLATA MEDICA. 57. 403-405 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] EMI OKUYAMA: "ANALGESIC PRINCIPLES FROM BORNEAN MEDICINAL PLANTS.TABERNAEMONTANA PAUCIFLORA BLUNE AND TABERNAEMONTANA PANDACAQUI POIR" CHEM.PHARM.BULL. 40. 2075-2079 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Takayama and S.Sakai: "Studies in Natural Product Chemistry,Vol.15" Elsevier(in press), 54 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 村越勇・山崎幹夫・坂井進一郎: "南江堂" 天然物化学(改定第4版) 分担執筆, 35 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] I.Murakoshi, T.Sekine, K.Maeshima, F.Ikegami, K.Yoshinaga, Y.Fujii, and S.Okonogi: "Absolute Configuration of L-Methionine Sulfoximine as a Toxic Principle in Cnestis palala MERR." Chem.Pharm.Bull.41(2). 388-390 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Sekine, Y.Arai, F.Ikegami, Y.Fujii, S.Shindo, T.Yanagisawa, Y.Ishida, S.Okonogi, and I.Murakoshi: "Isolation of Camelliaside C from Tea Seed Cake and Inhibitory Effects of Its Derivatives on Arachidonate 5-Lipoxygenase" Chem.Pharm.Bull.41(6). 1185-1187 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] I.Murakoshi, T.Sekine, H.Suzuki, C.Ninomiya, K.Saito, S.Okonogi, and F.Ikegami: "Monolignan and Diterpene Glycosides from the Stems of Tinospora rumphii Boerl." Thai J. Pharm. Sci.17(1). 33-37 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Sekine, N.Fukasawa, K.Saito, F.Ikegami, S.Okonogi, and I.Murakoshi: "A New Monoterpenoidal Carboxaminde from the Seeds of Acacia concinna" Thai J. Pharm. Sci.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] F.Ikegami, T.Sekine, O.Iijima, Y.Fujii, O.Okonogi, and I.Murakoshi: "Anti-Dermatophyte Activities of Tea Seed Cake and Pegu-catechu" Thai J. Pharm. Sci.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] SATOSHI TAKAMATSU, KAZUKI SAITO, SHIGERU OHMIYA, NUSIRI RUANGRUNGSI and ISAMU MURAKOSHI: "LUPIN ALKALOIDS FROM SOPHORA EXIGUA" Phytochemistry. 30. 3793-3795 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Emi OKUYAMA, Satoshi NISHIMURA, and Mikio YAMAZAKI: "Analgesic Principles from Aralia cordata THUNB." Chem.Pharm.Bull.39(2). 405-407 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Dhavadee PONGLUX, Sumphan WONGSERIPIPATANA, Norio AIMI, Naoko OYA, Hajime HOSOKAWA, Joju HAGINIWA, and Shin-ichiro SAKAI: "STRUCTURES OF TWO NEW BITTER PRINCIPLES ISOLATED FROM A THAI MEDICINAL PLANT, VERNONIA EXTENSA D.C." Chem.Pharm.Bull.40(2). 553-555 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Haruhiro FUJIMOTO, Yasuhiro TAKANO and Mikio YAMAZAKI: "Isolation, Identification and Pharmacological Studies on Three Toxic Metabolites from a Mushroom, Hebeloma spoliatum" Chem.Pharm.Bull.40(4). 869-872 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Norio AIMI, Hideo SEKI, and Shin-ichiro SAKAI: "SYNTHESIS OF LYALOSIDE, A PROTOTYPAL beta-CARBOLINE GLUCO INDOLE ALKALOID IN RUBIACEOUS PLANTS" Chem.Pharm.Bull.40(9). 2588-2590 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiromitsu Takayama, Mariko Kitajima, Koreharu Ogata, and Shin-ichiro Sakai: "The First and Biomimetic Construction of the New Skeleton of Gelselegine-Type Oxindole Alkaloids" J.Org.Chem.57. 4583-4584 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] DHAVADEE PONGLUX: "STRUCTURES OF TWO NEW BITTER PRINCIPLES ISOLATED FROM A THAI MEDICINAL PLANT,VERNONIA" CHEM.PHARM.BULL.40. 553-555 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Haruhiro FUJIMOTO: "ISOLATION,IDENTIFICATION AND PHARMACOLOGICAL STUDIES ON THREE TOXIC METABOLITES FROM A MUSHROOM,HEBELOMA SPOLATUM" CHEM.PHARM.BULL.40. 869-872 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Norio AIMI: "SYNTHESIS OF LYAOSIDE,A PROTOTYPAL β-CARBOLINE GLUCO INDOLE ALKALODE IN RUBIACEOUS PLANTS" CHEM.PHARM.BULL.40. 2588-2590 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Syunji HORIE: "EFECT OF HIRSUTNE,AN ANTIHYPERTENSIVE INDOLE ALKALOIDE FROM UNCARIA RHYNCHOPHYLLA,ON INTRCELLULAR CALCIUM IN RAT THORACIC AORTA" LIFE SCIENCES. 50. 491-498 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Isamu MURAKOSHI: "ABSOLUTE CONFIGURATION OF L-METHIONINE SULFOXIMINE AS A TOXIC PRINCIPLE IN CNFSTIS PALALA(LOUR.)MERR." THAIJ.PHARM.SCI.16. 149-162 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hiromitu TAKAYAMA: "THE FIRST AND BIOMIMETIC CONSTRUCTION OF THE 6 SKELTON OF GELSELEGINE-TYPE OXINDOLE ALKALOIDS" J.ORG.CHEM.57. 4583-4584 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] SATOSHI TAKAMATSU: "LUPIN ALKALOIDS FROM SOPHORA exigua" PHYTOCHEMISTRY. 30. 3793-3795 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] TOSHIKAZU SEKINE: "CAMELLIASIDE C AND INHIBITORY EFFECTS OF ITS DERIVATIVES ON ARACHIDONATE 5-LIPOXYGENASE" PLANTA MEDICA. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] EMI OKUYAMA: "ANALGESIC PRINCIPLES FROM BORNEAM MEDICINAL PLANTS,TABERNAEMONTANA PAUCIFLORA BLUME AND TABERNAEMONTANA PANDACAQUI POIR" CHEM.PHARM.BULL. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] EMI OKUYAMA: "ANALGESIC PRINCIPLES FROM ARALIA CORDATA THUNB." CHEM.PHARM.BULL. 39. 405-407 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] MARIKO KITAJIMA: "STEREOSELECTIVE TRANSFORMATION OF AJMALINE INTO THREE MINOR GELSEMIUM ALKALOIDS,KOUMIDINE,19Z-ANHYDROVOBASINEDIOL AND N-DEMETHOXYRANKINIKINE AND THEIR ABSOLUTE CONFIGURATION" J.CHEM.SOC.PERKIN TRANS.1.1773-1779 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] SHINGO YANO: "Ca^<++> CHANNEL BLOCKING EFFECTS OF HIRSUTINE,AN INDOLE ALKALOID FROM UNCARIA GENUS,IN THE ISOLATED RAT AORTA." PLATA MEDICA. 57. 403-405 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 村越 勇,山崎 幹夫,坂井 進一郎: "天然物化学(改定第4版) 分担執筆" 南江堂, 35 (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2025-11-19  

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