| Project/Area Number |
03045025
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | University-to-University Cooperative Research |
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KANEKO Masao Hammatsu University School of Medicine, Professor, 医学部, 教授 (90107805)
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| Co-Investigator(Kenkyū-buntansha) |
張 漢国 中国医科大学, 附属第一医院, 助手
徐 克 中国医科大学, 附属第一医院, 助教授
王 長龍 中国医科大学, 附属第一医院, 教授
何 芳顕 中国医科大学, 附属第一医院, 教授
KATO Toshihiko Hamamatsu University School of Medicine, Assistant, 医学部, 助手 (00185852)
OKAWADA Taketoshi Hamamatsu University School of Medicine, Clinical Assistant Professor, 医学部, 講師 (90169160)
TAKAHASHI Motoichiro Hamamatsu University School of Medicine, Associate Professor, 医学部, 助教授 (20115489)
AOKI Nobuo Hamamatsu University School of Medicine, Professor, 医学部, 教授 (10109762)
ZHANG Han-guo First Hospital of China Medical University, Assistant
XU Ke First Hospital of China Medical University, Associate Professor
WANG Chang-lung First Hospital of China Medical University, Professor
HE Fang-xian First Hospital of China Medical University Professor
中村 達 浜松医科大学, 医学部, 助教授 (00090027)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1991: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Budd-Chiari syndrome (BCS) / Epidemiology / Dietary habit / BCS animal model / Laminaria constrictor / Interventional Radiology (IVR) / Percutaneous transluminal angioplasty (PTA) / Expandable metallic stent (EMS) / Budd-Chiari症候群 / Balloon angioplasty / Metallic stent / 膜様狭窄 / 膜様閉塞 / 区域性狭窄 / 区域性閉塞 / BuddーChiari症候群 |
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| Research Abstract |
Imaging diagnosis of Budd-Chiari Syndrome (BCS) being easier and more accurate by the definite criteria of the disease, however, BCS is rather rare in Japan statistically. In this study epidemiological investigation was performed by the co-operation of Chinese hospitals, where more BCS patients were available. Fifty-four patients (33 males, 21 females) of BCS over 15 years of age were subjected to study for the symptoms and laboratory findings as well as the recent dietary habit of the BCS patients, compared with the 14 control patients of each circulatory and digestive disease in accordance with the age and sex.
The average onset ages were 30.3 years for males and 18.7 for females. Sex ratio was 1.57 ; more male than female. There was no characteristic family history nor past history. Abdominal distension and edema in the lower extremities were found in more than 75% of male and female patients. In males, melena, hematemesis and abdominal pain were frequently observed and abdominal pain and anorexia in females. It was noted that serum albumin was low and many patients had anemia and low platelet counts. More than 50% of the patients had enlarged liver, splenomegaly, esophageal varicies and dilated tortuous veins on the skin of abdominal and/or chest region. Smoking was not related to the disease. As for diet, BCS patients had more frequently potatoes and less frequently dried bean paste, rice in the morning, pork, vegetables and pear than 2 control groups. For fundamental study, experimental rat BCS model was developed by the use of laminaria constrictor.
Thirty-two patients of BCS were treated by interventional radiology (IVR). The initial treatment of 21 cases was percutaneous transluminal angioplasty (PTA)) only and later 11 cases were treated by expandable metallic stent (EMS) from the beginning. Re-stenosis was treated by PTA and/or EMS. The long term follow-up encourages the good outcome of IVR on BCS.
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