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A new nutrition with the knowledges of life science and molecular biology

Research Project

Project/Area Number 03303011
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 応用生物化学・栄養化学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SUGIMOTO Etsuro  Kyoto Univ., Agric., Prof., 農学部, 教授 (50026522)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Akira  Nagoya Univ., Agric., Prof., 農学部, 教授 (70035377)
NOGUCHI Tadashi  Tokyo Univ., Agric., Prof., 農学部, 教授 (50011937)
SUGANO Mitihiro  Kyushu Univ. Agric., Prof., 農学部, 教授 (70038181)
KIRIYAMA Shuhachi  Hokkaido Univ., Agric., Prof., 農学部, 教授 (00035396)
KIMURA Shuichi  Tohoku Univ., Agric., Prof., 農学部, 教授 (70005586)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥17,900,000 (Direct Cost: ¥17,900,000)
Fiscal Year 1992: ¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1991: ¥10,400,000 (Direct Cost: ¥10,400,000)
KeywordsCell proliferation and differentiation / Adipocytes / Serum cholesterol / Dietary fiber / Apo A-I / IGF-I / Pancreatic enzymes / Xenobiotics / セツバイオティクス / 血中コレステロ-ル / アボAーI / IGFーI
Research Abstract

Studies of new style of nutrition were performed with a cutting edge of a life science and molecular biology. It includes the interaction between nutrition intake and cell proliferation and differentiation, gene expression during development, regulation of digestion and absorption of nutrients, endocrinology and exocrinology and defense system of human beings.
In the course of the project, following new results in the nutrition fields were obtained. Preadipocyte growth factor was found in the adipose tissue. And ,mechanisms on retinoic acid depress the growth of the preadipicytes were figured out (Sugimoto). SHR and some strains of rats were investigated in the preference response to NaCl and alcohol. Animal protein fed rats prepered to alcohol, and found that some amino acid involved in the response (Kimura). Importance of the caecum for the cholesterol-lowering effect of dietary fibers (Kiriyama). Regulation of intestinal apo A-IV mRNA in rat pups was investi gated and some serious factors were elucidated (Sugano). mRNA stabilization of IGF-I and serum albumin by essential amino acids in the primary culture medium of liver was found (Noguchi). Molecular cloning of CCK-releasing peptide was performed (Fushiki). Effects of ascorbic acid deficiency on the drug-metabolizing enzymes in liver and cholesterol metabolism was studied in detail (Yoshida).

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Y.Kamei: "Lipoprotein lipase enzyme expression in 3T3-L1 adipocytes is posttranscriptionally down-regulated by retinoic acid." Biochem.Int.26. 923-934 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] F.Morimatsu: "Effects of diatary protein source and Umami on the palatability to sodium chloride in rats." Tohoku J.Agr.Res.43. 55-63 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.Ikeda: "Tea catechins decrease miceller solubility and intestinal absorption of cholesterol in rats." Biochim.Biophys.Acta. 1127. 141-146 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Imaizumi: "Cholesterol metabolism in ExHC (exogenous hypercholesterolmic) rats." Biochim.Biophys.Acta. 1123. 101-109 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Tsuzuki: "Molecular cloning and characterization of genes encoding rat pancreatic cholecystokinin (CCK)-releasing peptide (monitor peptide) and pancreatic secretory trypsin inhibitor (PSTI)." Biochim.Biophys.Acta. 1132. 199-202 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Mochizuki: "Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats." Biosci.Biotech.Biochem.56. 656-659 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Kamei, T.Kawada, A.Fujita, J.Etinne, L.Noe & E.Sugimoto: "Lipoprotein lipase enzyme expression in 3T3-L1 adipocytes is posttranscriptionally down-regulated by retinoic acid." Biochem. Int.26. 923-934 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] F.Morimatsu, I.Watanabe, M.Ito, K.Komai, Y.Furukawa & S.Kimura: "Effects of diatary protein source and Umami on the palatability to sodium chloride in rats." Tohoku J. Agr. Res.43. 55-63 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.Ikeda, Y.Imasato, E.Sasaki, M.Nakayama, H.Nagao, T.Takeo, F.Yayabe & M.Sugano: "Tea catechins decrease miceller solubility and intestinal absorption of cholesterol in rats." Biochim. Biophys. Acta. 1127. 141-146 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Imaizumi, A.Nagatomi, M.Sato, A.Tominaga & M.Sugano: "Cholesterol metabolism in ExHC (exogenous hypercholesterolmic) rats." Biochim. Biophys. Acta. 1123. 101-109 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Tsuzuki, Y.Miura, T.Fushiki, T.Oomori, T.Satoh, Y.Natori & E.Sugimoto: "Molecular cloning and characterization of genes encoding rat pancreatic cholecystokinin ( CCK)-releasing peptide (monitor peptide) and pancreatic secretory trypsin inhibitor (PSTI)." Biochim. Biophys. Acta. 1132. 199-202 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Mochizuki, H.Oda & A.Yoshida: "Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats." Biosci. Biotech. Biochem.56. 656-659 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Kamie: "Lipoprotein lipase enzyme expression in 3T3-L1 adipocytes is posttranscriptionally down-regulated by ratinoic acid." Biochem. Int.26. 923-934 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] F.Morimatsu: "Effects of diatary protein source and Umami on the palatability to sodium chloride in rats." Tohoku J. Agr. Res.43. 55-63 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] I.Ikeda: "Tea catechins decrease miceller solubility and intestinal absorption of cholesterol in rats." Biochim. Biophys. Acta. 1127. 141-146 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Imaizumi: "Cholesterol metabolism in ExHC(exogenous.hypercholesterolmic)rats." Biochim. Biophys. Acta. 1123. 101-109 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Tsuzuki: "Molecular cloning and characterization of genes encoding rat pancreatic cholecystokinin(CCK)-releasing peptide(monitor peptide)and pancreatic secretory trypsin inhibitor(PSTI)." Biochim. Biophys. Acta. 1132. 199-202 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Mochizuki: "Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats." Biosci. Biotech. Biochem.56. 656-659 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] R.Kawai: "Involvement of phosphoinisitolーglycan in induction of differetiation,from preadipocytes to adipocytes,of 3T3ーLl cells by insulinーlike growth factor I." Agric.Biol.Chem. 55. 2801-2806 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Kimura: "Nutritional studies of the roles of dietory protein levels and Umami in the preference response to sodium chloride for experimental animals." Physiology&Behavior. 49. 997-1002 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] A.Takenaka: "Distribution of messenger RNAs of insulinーlike growth factor (IGF)ーbinding proteinsーI and ー3 between parenchymal and nonparenchymal cells in rat liver." Agric.Biol.Chem.55. 1191-1193 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Nagaoka: "Effect of polychlorinated biphenyls on cholesterol and ascorbic acid metabolism in primary cultured rat hepatorytes." Biochem.Pharmacol.41. 1259-1261 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Oda: "Alterlation of serum lipoprotein metabolism by polychlorinated biphenyls and methionine in rats fed a soybean protein diet." J.Nutrition. 121. 925-933 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Tsuzuki: "Effect of highーprotein diet on the gene expression of a trypsinーsensitive,cholecystokininーreleasing peptide (monitor peptide) in the pancreas." Enr.J.biochem.199. 245-252 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Kawada: "Obesity:Dietary factors and control" Japan Sci.Soc Press/S.Karger, 272 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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