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ROLE OF CELL GROWTH FACTORS IN CONTROL OF DEVELOPMENT

Research Project

Project/Area Number 03304009
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 動物発生・生理学
Research InstitutionAZUBU UNIVERSITY

Principal Investigator

KURODA Yukiaki  AZUBU UNIV., DEPT. OF ENVIRON. HEALTH, PROFESSOR, 環境保健学部, 教授 (40000228)

Co-Investigator(Kenkyū-buntansha) IDE Hiroyuki  TOHOKU UNIV., FAC. OF SCI. ASSOC. PROFESSOR, 理学部, 助教授 (70022704)
NISHIKAWA Katsuzo  KANAZAWA MED. UNIV., MED. SCH. PROFESSOR, 医学部, 教授 (10029960)
NAKAMURA Toshikazu  KYUSHU UNIV., FAC. OF SCI. PROFESSOR, 理学部, 教授 (00049397)
NOMURA Tetsuo  SAITAMA UNIV., FAC. OF SCI. PROFESSOR, 理学部, 教授 (40072970)
ASASHIMA Makoto  YOKOHAMA CITY UNIV., DEPT. OF LIBERAL ART AND SCI., PROFESSOR, 文理学部, 教授 (00090564)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1992: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsCONTROL OF DEVELOPMENT / CELL GROWTH FACTOR / CELL DIFFERENTIATION / CULTURED CELL / FIBROBLAST GROWTH FACTOR / EPIDERMAL GROWTH FACTOR / TRANSFORMING GROWTH FACTOR / RECEPTOR / レセプタ-
Research Abstract

Effects of cell growth factors on embryonic development. cell differentiation, morphogenesis, and regeneration were examined using hydra, sea urchin, ascidian, amphibian, and chick embryos, mammals and cultured mammalian cells. Results obtained are as follows.
1. Factor(s) effective for proliferation and maintenance of interstitial cells were isolated and purified. The factor(s) had the molecular weight of 1,300 Da, and resembled to the head activating factor (HAF) (Fujisawa). The sensitive glutathione-induced response was found to detect the effect of cell growth factors (Hanai).
2. Exogastrula-inducing peptides (EGIP) isolated from sea urchin eggs or embryos had the molecular weight of 6 kDa and co-acted with some binding-proteins (Suemitsu). A intragenic retinal present in pithelial cells was active in morphogenesis of budding ascidians (Kawamura). Activin (TGF beta) present in unfertilized eggs of Xenopus laevis was effective for mesoderm induction. Activin A, AB and B were isolated … More and purified (Asashima).
3. Ectodermal bFGF was effective for proliferation of limb bud cells in chick embryos. It acted through the expression of the homeobox gene, chox-7 (Ide). A growth factor(s) secreted from chick scleral fibroblasts cultured in protein-free medium were effective in stimulating the proliferation of endothelial cells of human umbilical vein (Watanabe). Mullerian inhibiting substance (MIS) with the molecular weight of 74 kDa was purified from chick testes (Nomura).
4. Hepatocyte growth factor(HGF) was detected in liver, lung and kidney of rats. The molecular structure of the HGF DNA was analyzed (Nakamura). Neural monoclonal antibody to bFGF inhibited the formation of explanted tumors of bFGF-producing cells in nude mouse, but not inhibited the tumor formation of bFGF-non-producing cells (Nishikawa).
5. EGF and FGF stimulated the proliferation of non-dividing cells as well as dividing cells in clonal culture of human embryonic lung fibroblasts (Kuroda). The co-existance of PDGF and I collagen stimulated the migration of human embryonic skin fibroblasts in monolayer culture (Kondo). FGF and EGF acted as the stimulating factors for proliferation of human fibroblasts in serum-free medium, and TGF beta acted as the inhibiting factor (Kaji).The TGF receptor in endothelial cells of human umbilical vein was analyzed. The receptor was protein consisted of subunits of 80 kDa and 18 kDa (Hirai). Less

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report

Research Products

(189 results)

All Other

All Publications (189 results)

  • [Publications] Kuroda,Y.;Jain,A.K.;Tezuka,H.;& Kada,T.: "Antumutagenicity in cultured mammalian cells." Mutation Research. 267. 201-209 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kojima,H.,Konishi,H.& Kuroda,Y.: "Combined mutagenicity of methanesulfonate and ethy methanesulfonate in Chinese hamster V79 cells." Mutation Research. 266. 171-180 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kojima,H.,Konishi,H.& Kuroda,Y.: "Effects of L-ascorbic on the mutagenicity of ethyl methanesulfonate in cultured mammalian cells." Mutation Research. 266. 85-91 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamai,K.,Tezuka,H.& Kuroda,Y.: "Different modification by vaillin in cytotoxicity and genetic damages induced by EMS and H_2O_2 in cultured Chinese hamster cells." Mutation Research. 268. 231-237 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yokoiyama,A.,Kada,T.& Kuroda,Y.: "Inhibitor of potentially lethal damage (PLD) repaer,reduces the frequency of γ-ray-induced mutations in cultured Chinese hamster V79 cells." Mutation Research. 268. 247-254 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuroda,Y.: "Development and contributions of tissue cultuer studies in Japan." Tissue Culture Research Communications. 11. 287-303 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuroda,Y.,Shimada,T.,Sakaguchi,B.& Oishi,K.: "Effects of sex-ratio (SR)-spiroplasma infection on Drosophila primary embryonic cultured cells and on embryogenesis." Zoological Science. 9. 421-429 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujusawa,T.: "Homestatic recovery of interstitial cell populations in Hydra." Developmental Biology. 150. 185-192 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Oomura,T.,Sasaki,K.,Suzuki,K.,Muto,T.,Li,A-J.,Hanai,K.et: "A new brain glucosensor and its physiological significance." American Journal of Clinical Nutrition. 55. 278S-282S (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakayasu,H.,Mizutani,H.,Hanai,K.,Kimura,H.& Kuriyama,K.: "Monoclonal antibody to GABA binding protein,a possible GABA receptor." Biochem.Biophys.Res.Commun.182. 722-726 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta,K.,Hanae,K.& Morita,H.: "Glutathione-binding protein identified by monoclonal antibodies which depress the behavioral response evoked by glutathione in Hydra." Biochim.Biophys.Acta. 1117. 136-142 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuriyama,K.,Nakayasu,H.,Mizutani,H.,Hanai,K.,& Kimura,H.: "Structure and function of GABAB receptor in bovine cerebral cortex:analysis using the purified recepter and monoclonal antibody." Pharmacology Communications. 2. 15-19 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tooyama,I.,Walker,D.,Yamada,T.,Hanai,K.,et al.: "High molecular weight basis fibroblast growth factor-like protein is located to a subpopulation of mesencephalic dopaminergic neurons the rat brain." Brain Research. 593. 274-280 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sasaki,K.,Oomura,Y.,Suzuki,K.,Hanai,K.& Tagi,H.: "Acidic fibroblast growth factor prevents death of hippocampal calpyramidal cells following ischemia." Nutrochem.Int.21. 397-402 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kinoshita,K.,Fujii,Y.,Fujita,K.,Yamasu,K.,Suyemitsu,T.& Ishihara,K.: "Maternal exogastrula-inducing piptides (EGIPs) and their changes during development in the sea urchin Anthocidaris crassispina." Development Growth & Differentiation. 34. 661-668 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hara,K.,Fujiwara,S.& Kawamura,K.: "Retinoic acid can induce a secondary axis in developing buds of a colonial ascidian,Polyandrocarpa misakiensis." Development Growth & Differentiation. 34. 437-445 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujiwara,S.& Kawamura,K.: "Ascidian budding as a transdifferentiation-like system:Multipotent epithelium is not undifferentiated." Development Growth & Differentiation. 34. 463-472 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakamura,T.,Asashima,M.et al.: "Isolation and characterization of native activen B." Journal of Biological Chemistry. 267. 16385-16389 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Uesuhi,T.,Ohta,Y.,Asashima,M.& Iguchi,T.: "Comparative study of sexual dimorphism of the innominate bone in rodents and amphibians." Anatomical Record. 234. 432-437 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Morita,M.& Asashima,M.: "Mesoderm and neural induction on newt ectoderm by activin A." Development Growth & Differentiation. 34. 589-594 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Oka,K.,Kishi,K.,Shiroya,T.,Asashima,M.et al.: "Reduction of papilloma size by ultraviolet irradiation in the Japanese newt,Cynopus pyrrhogaster." Journal of Comparative Pathology. 106. 1-8 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Uchiyama,M.& Asashima,M.: "Specific erythroid differentiation of mouse erythroleukemia cells by activins and its enhancement by retinoic acids." Biochem.Biophys.Res.Commun.187. 347-352 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fukui,A.,Tashiro,A.,Koyama,H.,Iwamura,T.& Asashima,M.: "A new cell line (XTY) form a tumor of Xenopus laevis." Experientia. 48. 87-91 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohya,Y.,Watanabe,K.et al.: "Scleral fibroblasts of the chick embryo can proliferate without transferrin in protein-free culture." Zoological Science. 9. 749-755 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Watanabe,K.,Yagi,K.,Ohta,Y.& Kimata,K.: "Scleraly fibroblats of the chick embryo differentiate into chondrocytes in soft-agar culture." In Vitro Cell and Development Biology. 28A. 603-608 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sawada,K.& Nomura,T.: "Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)." Acta Anatomica. 143. 241-245 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sawada,K.& Nomura,T.: "Differential effects of testosterone and 5α-dihydrotesto-sterone on growth in mouse submandibular gland." Zoological Sceince. 9. 803-809 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamamoto,M.,Fujita,K.,Shinkai,T.,Yamamoto,K.& Nomura,T.: "Identification of the phenotypic modulation of rabbit arterial smooth muscle cells in primary culture by flow cytometry." Experimental Cell Research. 198. 43-51 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamamoto,K.,Yamamoto,K.& Nomura,T.: "Disassembly of F-actin filaments in human endothelial cells cultured on type U collagen." Experimental Cell Research. 201. 55-63 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Uesugi,T.,Taguchi,O.,Numura,T.& Iguchi,T.: "Effects of sex steroids on the development of sexual dimorphism in mouse innominate bose." Anatomical Record. 234. 541-548 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shiota,G.,Rhoads,D.B.,Wang,T.C.,Nakamura,T.et al.: "Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells." Proc.Natl.Acad.Sci.USA. 89. 373-377 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tajima,H.,Higuchi,O.,Mizuno,K.& Nakamura,T.: "Tissue distribution of hepatocyte growth factor receptor and its exclusive down-regulation in a regenerating organ after injury." Journal of Biochemistry. 111. 401-406 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tajima,H.,Matsumoto,K.& Namamura,T.: "Regulation of cell growth and motility by hepactocyte growth factor and receptor extression in various cell species." Experimentel Cell Research. 202. 423-431 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahara,T.,Matsumoto,K.& Nakamura,T.: "Cell density-dependent regulation of albumin synthesis and DNA synthesis in rat repatocytes by hepatocyte growth factor." Journal of Biochemistry. 112. 330-334 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osaka,S.,Saji,S.,Nakamura,T.& Nozawa,Y.: "Cytosolic calcium oscilation induced by hepatocyte growth factor (HGF) in single Fura-2-loaded cultured hepatocytes." Biochemica Biophysica Acta. 1135. 229-232 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsumoto,K.,Okazaki,H.& Nakamura,T.: "Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts." Biochem.Biophys.Res.Commun.188. 235-243 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kagoshima,M.,Kinosheta,T.,Matsumoto,Y.& Nakamura,T.: "Change in expression of mRNA and receptor for hepatocyte growth factor in liver,kidney and lung during postnatal development in rats." Europian Journal of Biochemistry. 210. 375-380 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamada,K.,Yoshitake,Y.,Norimatsu,H.& Nishikawa,K.: "Roles of various growth factors in growth of hyman osteosarcoma cells which can grow in protein-free medium." Cell Structure and Function. 17. 9-17 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakanishi,Y.,Kihara,K.,Mizuno,K.,Masasune,Y.,Yoshitake,Y.& Nishikawa,K.: "Direct effect of basic fibroblast gworth factor on gene transcription in a cell-free system." Proc.Natl.Acad.Sci.USA. 89. 5216-5220 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshitake,Y.& Nishikawa,K.: "Distribution of fibroblast growth factor in cultured tumor cells and their transplants." In Vitro Cell Developmental Biology. 28A. 419-428 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yonezawa,Y.,Kondo,H.,Hirai,R.,Kaji,K.& Nishikawa,K.: "Species-specific differences in the nitogenic activity of heparin-binding browth factors in the sera of varios mammals." Experientia. 48. 239-245 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kondo,H.,Matsuda,R.& Yonezawa,K.: "Platelet-derived growth factor in combimation with collagen promotes the migration of human skin fibroblasts into a denuded area of a cell monolayer." Experimental Cell Research. 202. 45-51 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kondo,H.& Yonezawa,Y.: "Changes in the migratory ability of hyman lung and skin fibroblasts during in vitro aging and in vivo cellular senescence." Mech.Ageing Development. 63. 223-233 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kondo,H.& Yonezawa,Y.: "Autocrine regulation of the migration of human fetal skin fibroblasts." Zoological Science. 9. 1286 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yanagissws,Miwa,A.,Uchida,Y.,et al.& Kaji,K.: "Salvage of infected myocardium by angiogenic action of basic fibroblast growth factor." Science. 257. 1401-1403 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hirai,R.& Kaji,K.: "Transforming growth factor TGFB-1-specitic binding proteins on human vascular endothelial cells." Experimental Cell Research. 201. 119-125 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hirai,R.& Kaji,K.: "Susceptibility to TGFBof human umbilical vein endothelial cells and the expression of TGFB receptor/binding proteins on these cells." Tissue Culture Research Communications. 11. 317-327 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuroda,Y.: "Natural Resources and Human Health:Plants of Medical and Nutritional Value." Elsevier(Amsterdam,London,NewYork and Tokyo), 111-119 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Mizuno,K.& Nakamura,T.: "Hepatocyete Grown Factot-Scatter Factor and cーMet Reseptor.ー" Birkhause Verlag, 1-29 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuroda, Y., Jain, A. K., Tezuka, H. & Kada, T.: "Antimutagenicity in cultured mammalian cells." Mutation Res.267. 201-209 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kojima, H., Konishi, H. & Kuroda, Y.: "Combined mutagenicity of methyl methanesulfonate and ethyl methanesulfonate in Chinese hamster V79 cells." Mutation Res.266. 171-180 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kojima, H., Konishi, H. & Kuroda, Y.: "Effects of L-ascorbic acid on the mutagenicity of ethyl methanesulfonate in cultured mammalian cells." Mutation Res.266. 85-91 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamai, K., Tezuka, H. & Kuroda, Y.: "Different modification by vanillin in cytotoxicity and genetic damages induced by EMS and H_2O_2 in cultured Chinese hamster cells." Mutation Res.268. 231-237 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yokoiyama, A., Kada, T. & Kuroda, Y.: "Inhibitor of potentially lethal damage (PDL) repair, reduces the frequency or gamma-ray-induced mutations in cultured Chinese hamster cells." Mutation Res.268. 247-254 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuroda, Y.: "Development and contributions of tissue culture studies in Japan." Tissue Culture Res. Commun.11. 287-303 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuroda, Y.: "Natural Resources and Human Health: Plants of Medical and Nutritional Value." Elsevier, Amsterdam, London New York and Tokyo. 111-119 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuroda, Y., Shimada, Y., Sakaguchi, B. & Oishi, K.: "Effects of sex-ratio(SR)-spiroplasma infection on Drosophila primary embryonic cultured cells and on embryogenesis." Zool. Sci.9. 421-429 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujisawa, T.: "Homeostatic recovery of interstitial cell populations in Hydra." Develop. Biol.150. 185-192 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Oomura, Y., Sasaki, K., Suzuki, K., Muto, T., Li, A-J., Ogita, Z., Hanai, K. et al.: "A new glucosensor and its physiological significance." Amer.J.Clinical Nutrition. 55. 278S-282S

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakayasu, H., Mizutani, H., Hanai, K., Kimura, H. & Kuri-yama, K.: "Monoclonal antibody to GABA binding protein, a possible GABA_B receptor." Biochem.Biophys.Res. Commun.182. 722-726 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta, K., Hanai, K. & Morita, H.: "Glutathione-binding protein identified by monoclonal antibodies which de-press the behavioral response evoked by glutathione in Hydra." Biochim.Biophys.Acta. 1117. 136-142 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuriyama, K., Nakayasu, H., Mizutani, H., Hanai, K. & Kimura, H.: "Structure and function of GABA_B receptor in bovine cerebral cortex: analysis using the purified receptor and monoclonal antibody." Pharmacol.Commun.2. 15-19 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tooyama, I., Walker, D., Yamada, T., Hanai, K. et al.: "High molecular weight basic fibroblast growth factor-like protein is located to a subpopulation of mesencephalic depaminergic neurons in the rat brain." Brain Res.593. 274-280 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sasaki, K., Oomura, Y., Suzuki, K., Hanai, K. & Yagi, H.: "Acidic fibroblast growth factor prevents death of hippocampal cal pyramidal cells following ischemia." Neurochem.Int.21. 397-402 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kinoshita, K., Fujii, Y., Fujita, K., Yamasu, K., Suye-mitsu, T. & Ishihara, K.: "Maternal exogastrula-inducimg peptides (EGIPs) and their changes during development in the sea urchin Anthocidaris crassispina." Develop.Growth Differ.34. 661-668 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hara, K., Fujiwara, S. & Kawamura, K.: "Retinoic acid can induce a secondary axis in developing buds of a clonial ascidian, Polyandrocarpa miosakiensis." Develop.Growth Differ.34. 437-445 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujiwara, S. & Kawamura, K.: "Ascidian budding as a transdifferentiation-like system: Multipotent epithelium is not undifferentiated." Develop.Growth Differ.34. 463-472 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakamura, T., Asashima, M. et al.: "Isolation and characterization of native activin B." J.Biol.Chem.267. 16385-16389 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Uesugi, Y., Ohta, Y., Asashima, M. & Iguchi, T.: "Comparative study of sexual dimorphism of the innominate bone in rodents and amphibians." Anat. Rec.234. 432-437 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Morita, N. & Asashima, M.: "Mesoderm and neural induction on newt ectoderm by activin A." Develop.Growth Differ.34. 589-594 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Oka, K., Kishi, K., Shiroya, T., Asashima, M. et al.: "Reduction of papilloma size by ultraviolet irradiation in the Japanese newt, Cynopus pyrrhogaster." J.Comp.Pathol.106. 1-8 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Uchiyama, H. & Asashima, M.: "Specific erythroid differentiation of mouse erythroleukemia cells by activins and its enhancement by retinoic acids." Biochem.Biophys.Res. Commun.187. 347-352 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fukui, A., Tashiro, A., Koyama, H., Iwamura, Y. & Asa-shima, M.: "A new cell line (XTY) from a tumor of Xenopus laevis." Experientia. 48. 87-91 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohya, Y., Watanabe, K. et al.: "Scleral fibroblasts of the chick embryo can proliferate without transferrin in protein-free culture." Zool.Sci.9. 749-755 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Watanabe, K., Tagi, K., Ohya, Y. & Kimata, K.: "Scleral fibroblasts of the chick embryo differentiate into chondrocytes in soft-agar culture." In Vitro Cell Develop. Biol.28A. 603-608 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sawada, K. & Nomura, T.: "Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)." Acta Anat.143. 231-245 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sawada, K. & Nomura, T.: "Differential effects of testosterone and 5alpha-dihydrotestosterone on growth in mouse submandibular gland." Zool.Sci.9. 803-809 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamamoto, M., Fujita, K., Shinkai, T., Yamamoto, M. & Nomura, T.: "Identification of the phenotypic modulation of rabbit arterial smooth muscle cells in primary culture by flow cytometry." Exp.Cell Res.198. 43-51 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamamoto, K., Yamamoto, M. & Nomura, T.: "Disassembly of F-actin filaments in human endothelial cells cultured on type V collagen." Exp.Cell Res.201. 55-63 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Uesugi, Y., Taguchi, O., Nomura, T. & Iguchi, T.: "Effects of sex steroids on the development of sexual dimorphism in mouse innominate bone." Anat. Rec.234. 541-548 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shiota, G., Rhoads, D. B., Wang, T. C., Nakamura, T. et al.: "Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells." Proc.Nat.Acad.Sci.USA. 89. 373-377 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tajima, H., Higuchi, O., Mizuno, K. & Nakamura, T.: "Tissue distribution of hepatocyte growth factor receptor and its exclusive down-regulation in a regenerating organ after injury." J.Biochem.111. 401-431 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tajima, H., Matsumoto, K. & Nakamura, T.: "Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species." Exp.Cell Res.202. 423-431 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahara, T., Matsumoto, K. & Nakamura, T.: "Cell density-dependent regulation of albumin synthesis and DNA synthesis in rat hepatocytes by hepatocyte growth factor." J.Biochem.112. 330-334 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osada, S., Saji, S., Nakamura, T. & Nozawa, Y.: "Cytosolic calcium oscillation induced by hepatocyte growth factor (HGF) in single Fura-2-loaded cultured hepatocytes." Biochem.Biophys.Acta. 1135. 229-232 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsumoto, K., Okazaki, H. & Nakamura, T.: "Up-regulation of hepatocyte growth factor gene express-ion by interleukin-1 in human skin fibroblasts." Biochem.Biophys.Res.Commun.188. 235-243 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kagoshima, M., Kinoshita, T., Matsumoto, T. & Naka-mura, T.: "Changes in expression of mRNA and receptor for hepatocyte growth factor in liver, kidney and lung during postnatal development in rats." Europ.J.Biochem.210. 375-380 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Mizuno, K. & Nakamura, T.: "Hepatocyte Growth Factor-Scatter Factor and c-Met Receptor." Birkhauser Verlag.1-29 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamada, K., Yoshitake, Y., Norimatsu, H. & Nishi-kawa, K.: "Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free system." Cell Structure Funct.17. 9-17 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakanishi, Y., Kihara, K., Mizuno, K., Masasune, Y. Yoshitake, Y. & Nishikawa. K.: "Direct effect of basic fibroblast growth factor on gene transcription in a cell-free system." Proc.Nat.Acad.Sci.USA. 89. 5216-5220 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshitake, Y. & Nishikawa, K.: "Distribution of fibroblast growth factor in cultured tumor cells and their transplants." In Vitro Cell Develop. Biol.28A. 419-428 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yonezawa, Y., Kondo, H., Hirai, R., Kaji, K. & Nishikawa, K.: "Species-specific deferences in the mitogenic activity of heparin-binding growth factors in the sera of various mammals." Experientia. 48. 239-245 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kondo, H., Matsuda, R. & Yonezawa, Y.: "Platelet-derived growth factor in combination with collagen promotes the migration of human skin fibroblasts into a denuded area of a cell monolayer." Exp.Cell Res.202. 45-51 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kondo, H. & Yonezawa, Y.: "Changes in the migratory ability of human lung and skin fibroblasts during in vitro aging and in vivo cellular senescence." Mech.Ageing Develop.63. 223-233 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kondo, H. & Yonezawa, Y.: "Autocrine regulation of the migration of human fetal skin fibroblasts." Zool.Sci.9. 1286 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yanagisawa-Miwa, A., Uchida, Y. et al. Kaji, K.: "Salvage of infected myocardium by angiogenic action of basic fibroblast growth factor." Science. 257. 1401-1403 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hirai, R. & Kaji, K.: "Transforming growth factor TGF beta-specific binding proteins on human vascular endothelial cells." Exp.Cell Res.201. 119-125 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hirai, R. & Kaji, K.: "Susceptibility to TGF beta of human umbilical vein endothelial cells and the expression of TGF beta receptor/binding protein." Tissue Culture Res. Commun.11. 317-327 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuroda,Y.,Jain,A.K.,Tezuka,H.&Kada,T.: "Antimutagenicity in cultured mammalian cells." Mutation Research. 267. 201-209 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kojima,H.,Konishi,H.&Kuroda,Y.: "Combined mutagenicity of methyl methanesulfonate and ethyl methanesulfonate in Chinese homster V79 cells." Mutation Research. 266. 171-180 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kojima,H.,Konishi,H.&Kuroda,Y.: "Effects of L-ascorbic acid on the mutagenicity of ethyl methanesulfonate in cultured mammalian cells." Mutation Research. 266. 85-91 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tamai,K.,Tezuka,H.&Kuroda,Y.: "Different modification by vanillin in cytotoxicity and genetic damages induced by EMS and H_2O_2 in cultured Chinese hamster cells." Mutation Research. 268. 231-237 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yokoiyama,A.,Kada,T.&Kuroda,Y.: "Inhibitor of potentially lethal damage(PDL)repair,reduces the frequency of r-ray-induced mutations in cultured Chinese hamster V79 cells." Mutation Research. 268. 247-254 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kuroda,Y.: "Development and contributions of tissue culture studies in Japan." Tissue Culture Research Communications. 11. 287-303 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kuroda,Y.,Shimada,Y.,Sakaguchi,B.&Oishi,K.: "Effects of sex-ratio(SR)-spiroplasma infection on Drosophila primary embryonic cultured cells and on embryogenesis." Zoological Science. 9. 421-429 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fujisawa,T.: "Homeostatic recovery of interstitial cell populations in Hydra." Developmental Biology. 150. 185-192 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Oomura,Y.,Sasaki,K.Suzuki,K.,Muto,T.,Li,A-J.,Hamai,K.et: "A new brain glucosensor and its physiological significance." American Journal of Clinical Nutrition. 55. 278S-282S (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nakayasu,H.,Mizutani,H.,Hanai,K.,Kimura,H.&Kuriyama,K.: "Monoclonal antibody to GABA binding protein,a possible GABA receptor." Biochem.Biophys.Res.Commun.182. 722-726 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ohta,K.,Hanai,K.&Morita,H.: "Glutathione-binding protein identified by monoclonal antibodies which depress the behavioral response evoked by glutathione in Hydra." Biochim.Biophys.Acta. 1117. 136-142 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kuriyama,K.,Nakayasu,H.,Mizutami,H.,Hanai,K.&Kimura,H.: "Structure and function of GABA_B receptor in bovine cerebral cortex:analysis using the purified receptor and monoclonal antibody." Pharmacology Communications. 2. 15-19 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Uesugi,Y.,Ohta,Y.,Asashima,M.&Iguchi,T.: "Comparative study of sexual dimorphism of the innominate bone in rodents and amphibians." Anatomical Record. 234. 432-437 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Morita,N.&Asashima,M.: "Mesoderm and neural induction on newt ectoderm by activin A." Development Growth&Differentiation. 34. 589-594 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Oka,K.,Kishi,K.,Shiroya,T,Asashima,M.et al.: "Reduction of papilloma size by ultraviolet irradiation in the Japanese newt,Cynopus pyrrhogaster." Journal of Comparative Pathology. 106. 1-8 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Uchiyama,H.&Asashima,M.: "Specific erythroid differentiation of mouse erythroleukemia cells by activins and its enhancement by retinoicacids." Biochem.Biophys.Res.Commun.187. 347-352 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fukui,A.,Tashiro,A.,Koyama,H.,Iwamura,Y.&Asashima,M.: "A new cell Line(XTY)from a tumor of Xenopus laevis." Experientia. 48. 87-91 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ohya,Y.,Watanabe,K.et al.: "Scleral fibroblasts of the chick embryo can proliferate without transferrin in protein-free culture." Zoological Science. 9. 749-755 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Watanabe,K.,Yagi,K.,Ohya,Y.&Kimata,K.: "Scleralfibroblats of the chick embryo differentiate into chondrocytes in soft-agar culture." In Vitro Cell and Developmental Biology. 28A. 603-608 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sawada,K.&Nomura,T.: "Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation(Tfm/Y)." Acta Anatomica. 143. 241-245 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sawada,K.&Nomura,T.: "Differential effects of testosterone and 5α-dihydrotestosterone on growth in mouse submandibular gland." Zoological Science. 9. 803-809 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamamoto,M.,Fujita,K.,Shimkai,T.,Yamamoto,K.&Nomura,T.: "Identification of the phenotypic modulation of rabbit arterial smooth muscle cells in primary culture by flowcytometry." Experimental Cell Research. 198. 43-51 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamamoto,K.,Yamamoto,M.&Nomura,T.: "Disassembly of F-actin filaments in human endothelial cells cultured on type U collagen." Experimental Cell Research. 201. 55-63 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Uesugi,Y.,Taguchi,O.Numura,T.&Iguchi,T.: "Effects of sex steroids on the developmint of sexual dimorphism in mouse innominate bose." Anatomical Record. 234. 541-548 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Shiota,G.Rhoads,D.B.,Wang,T.C.,Nakamura,T.et al.: "Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells." Proc.Natl.Acad.Sci.USA. 89. 373-377 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tajima,H.Higuchi,O.,Mizuno,K.&Nakamura,T.: "Tissue distribution of hepatocyte growth factor receptor and its exclusive down-regulation in a regenerating organ after injury." Journal of Biochemistry. 111. 401-406 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tajima,H.,Matsumoto,K.&Namamura,T.: "Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species." Experimental Cell Research. 202. 423-431 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takahara,T.,Matsuoto,K.&Nakamura,T.: "Cell density-dependent regulation of albumin synthesis and DNA synthesis in rat hepatocytes by hepatocyte growth factor." Journal of Biochemistry. 112. 330-334 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Osada,S.,Saji,S.,Nakamura,T.&Nozawa,Y.: "Cytosolic calcium oscilation induced by hepatocyte growth factor(HGF)in single Fura-2-loaded cultured hepatocytes." Biochemica Biophysica Acta. 1135. 229-232 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Matsumoto,K.,Okazaki,H.&Nakamura,T.: "Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts." Biochem.Biophys.Res.Commun.188. 235-243 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kagoshima,M.,Kinoshita,T.,Matsumoto,T.&Nakamura,T.: "Change in expression of mRNA and recepor for hepatocyte growth factor in liver,kidney and lung during postnatal development in rats." Europian Journal of Biochemistry. 210. 375-380 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamada,K.,Yoshitake,Y.,Norimatsu,H.&Nishikawa,K.: "Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free medium." Cell Structure and Function. 17. 9-17 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nakamishi,Y.,Kihara,K.,Mizuno,K.,Masasune,Y.Yoshitake,Y.&Nishikawa,K.: "Direct effect of basic fibroblast growth factor on gene transcription in a cell-free system." Proc.Natl.Acad.Sci.USA. 89. 5216-5220 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshitake,Y.&Nishikawa,K.: "Distribution of fibroblast growth factor in cultured tumor cells and their transplants." In Vitro Cell Developmental Biology. 28A. 419-428 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yonezawa,Y.,Kondo,H.,Hirai,R.,Kaji,K.&Nishikawa,K.: "Species-specific differences in the mitogenec activity of heparin-binding growth factors in the sera of varios mammals." Experientia. 48. 239-245 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kondo,H.,Matsuda,R.&Yonezawa,K.: "Platelet-derived growth factor in combination with collagen promotes the migration of human skin fibroblasts into a denuded area of a cell monolayer." Experimental Cell Research. 202. 45-51 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kondo,H.&Yonezawa,Y.: "Changes in the migratory ability of human lung and skin fibroblasts during in vitro aging and in vivo cellular senescence." Mech.Ageing Development. 63. 223-233 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kondo,H.&Yonezawa,Y.: "Autocrine regulation of the migration of human fetal skin fibroblasts." Zoological Science. 9. 1286 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yanagissws,Miwa,A.,Uchida,Y.,et al.&Kaji,K.: "Salvage of infected myocardium by angiogenic action of basic fibroblast growth factor." Science. 257. 1401-1403 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hirai,R.&Kaji,K.: "Transforming growth factor TGFβ-1-specific binding proteins on human vascular endothelial cells." Experimental Cell Research. 201. 119-125 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hirai,R.&Kaji,K.: "Susceptibility to TGFβ of human umbilical vein endothelial cells and the expression of TGFβ receptor/binding proteins on these cells." Tissue Culture Research Communications. 11. 317-327 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kuroda,Y.: "Natural Resources and Human Health:Plants of Medical and Nutritional Value." Elsevier(Amsterdam,London,New York and Tokyo), 111-119 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Mizuno,K.&Nakamura,T.: "Hepatocyte Growth Factor-Scatter Factor and c-Met Reseptor." Birkhauser Verlag, 1-29 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kuroda,Y.,Jain,A.K.,Tezuka,H.& Kada,T.: "Antimutagenicity in cultured mammalian cells." Mutation Res.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kojima,H.,Konishi,H.& Kuroda,Y.: "Effects of Lーascorbic acid on mutagenicity of ethyl methaneーsulfonate in cultured mammalian cells." Mutation Res.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kojima,H.,Konishi,H.& Kuroda,Y.: "Combined mutagenicity of methyl methanesulfonate and ethyl methaneーsulfonate in Chinese hamster V79 cells." Mutation Res.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tamai,K.,Tezuka,H.& Kuroda,Y.: "Different modifications by vanillin in cytotoxicity and genetic changes induced by EMS and H_2O_2 in cultured Chinese hamster cells." Mutation Res.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yokoiyama,A.,Kada,T.& Kuroda,Y.: "Inhibitor of potentially lethal damage(PLD)repair,reduces the frequency of γーrayーinduced mutations in cultured Chltured Chinese hamster V79 cells." Mutation Res.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kuroda,Y.,Shimada,Y.,Sakaguchi,B.& Oishi,K.: "Effects of sexーRatio(SR)ーspiroplasma infection of Drosophila primary embryonic cultured cells and on embryogenesis." Zool.Sci.9. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kawamura,K.and Nakauchi,M.: "Homeostatic integration of stem cell dynamics during plalleal budding of ascidians." Zool.Sci.8. 11-22 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kawamura,K.,Nomura,M.,Kameda,T.,Shimamoto,H.and Nakauchi.: "Selfーnonself recognition activity extracted from selfーsterile eggs of the ascidian,Ciona intestinalis." Develop.Growth Differ.33. 139-148 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kawamura,K.and Nakauchi,M.: "The effect of aphidicolin on morphogenesis of epithelial stem cells during budding in ascidians." Mem.Fac.Sci.Kochi Univ.Ser.D. 12. 61-65 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kawamura,K.,Fujiwara,S.and Sugino,Y.M.: "Buddingーspecific lectin induced in epithelial cells is and extracellular matrix component for stem cell aggregation in tunicates." Development. 113. 995-1005 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kawamura,K.,Ymamoto,t.,Sugino,Y.M.and Fujiwara,S.: "Alkaline phosphatase and peroxydase activities of blood cells in the polystyelid ascidian,Polyandrocarpa misakiensis." Merm Fac.Sci.Kochi Univ.Ser.D. 13. 19-27 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Fujiwara,S.,Xu,J.and Kawamura,K.: "One step separation of mesenchymal cells of the ascidian Polyandrocarpa misakiensis." Mem.Fac.Sci.Kochi Univ.Ser.D. 13. 29-36 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] David,C.N.,Fujisawa,T.,& Bosch,T.C.G.: "Interstitial stem cell proliferation in Hydra;Evidence for strainーspecific regulatory sighal." Develop.Biol.148. 501-507 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Fujisawa,T.: "Homeostatic recovery of interstitial cell population in Hydra." Develop,Biol.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sakaguchi,M.,Hanai,K.Ohta,K.,Kitajima,M.,Matsuhashi,S.,Hori,K.& Morita,H.: "Monoclonal antibodies that depress a specific subset of multiple components of the glutathinoneーinduced response of Hydra." J.Comp.Physiol.168. 409-416 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tooyama,I.,Hara,Y.Yasuhara,O.,Oomura,Y.Hanai,K.et al.: "Production of antisera to acidic fibroblast growth factor and their application to immunohistochemical study in rat brain." Nouroscience. 40. 769-779 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nakayasu,H.,Mizutani,H.,Hanai,K.,Kimura,H.& Kuriyama,K.: "Monoclonal antibody to GABA binding protein,a possible GABA receptor" Biochem.Biophys.Res.Commun.182. 722-726 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Suyemitsu,T.,Fujii,Y.,Kinosita,K.,Yamasu,K.& Ishihara,K.: "Changes of exogastrulaーinducing activities in eggs or embryos of the sea urchin,Anthocidaris crassispina,during development." Zool.Sci.8. 1085 (1991)

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      1991 Annual Research Report
  • [Publications] Sugino,Y.M.,Koguchi,S.and Kawamura,K.: "Ultrastructure of cellーtoーcell contact in epidermai stolon of the ascidian Perophora japonica." Mem.Fac.Sci.Kochi Univ.Ser.D. 13. 37-43 (1992)

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      1991 Annual Research Report
  • [Publications] M.Asashima,H.,Nakano,H.,Uchiyama,H.,Sugino T.,Nakamura,Y.,Eto,D.Ejima,M.Davids,S.Plossow,I.Cichoka and K.Kinoshita: "Follistatin inhibits the mesoderm inducing activity of activin A and the vegetalizing factor from chicken embryo." Rouxs Archives Develop.Biol.,200(1). 4-7 (1991)

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      1991 Annual Research Report
  • [Publications] M.Asashima,H.Nakano,H.Uchiyama,H.Sugino,T.Nakamura,Y.Eto,D.Ejima,S.I.Nishimatsu N.Ueno and K.Kinoshita: "The presence of activin(Erythroid Differentiation Factor)in unfertilized eggs and blastulae of Xenopus lacvis." Proc.N.A.S.88(15). 6511-6514 (1991)

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      1991 Annual Research Report
  • [Publications] Asashima,M.,Uchiyama,H.,Nakano,H.et al.: "The vegetalizing factor from chicken embryos; Its EDF(activin)ーlike activity." Mechanism of Cell Development. 34. 135-141 (1991)

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      1991 Annual Research Report
  • [Publications] Asashima,M.,Shimada,K.& Pfeiffer,C.J.: "Magnetic shieldding induces early developmental abnormalities in the newt,Cynops pyrrhogaster." Bioelectromagnetics. 12. 215-224 (1991)

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      1991 Annual Research Report
  • [Publications] Fukui,A.Tashiro,A.,Koyama,H.,Iwamura,Y.& Asashima,M.: "A new cell line(XTY)from a tumor of Xenopus laevis." Experientia. 48. 87-91 (1992)

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      1991 Annual Research Report
  • [Publications] Arizumi,T.Moriya,N.Uchiyama,H.& Asashima,M.: "Concentration dependent inducing activity of activin A." Roux's Archives Develop.Biol.200. 230-233 (1991)

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      1991 Annual Research Report
  • [Publications] Noji,S.,Nohno,T.,Kyoama E.,Muto K.,Ohyama K.,Aoki Y.,Tamura K.,Ohsugi K.,Ide H.,Taniguchi S.,Saito T.: "Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud." Nature. 350. 83-86 (1991)

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      1991 Annual Research Report
  • [Publications] Yokouchi Y.,Ohsugi K.,Uchiyama K.and Ide H.: "Control of the expression of AVー1 protin,a positionーspecific antigen,by ZPA factor in the chick limb bud." Develop.Growth & Differ.33. 173-180 (1991)

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      1991 Annual Research Report
  • [Publications] T.Kobayashi,T.Suzuki and T.Noumura: "Purification of chicken testicular Mullerian inhibiting substance." Zoological Science. 8. 1167 (1991)

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      1991 Annual Research Report
  • [Publications] Toshikazu Nakamura: "Structure and function of hepatocyte growth factor." Progress in Growth Factor Research. 3. 67-85 (1991)

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      1991 Annual Research Report
  • [Publications] Matsumoto,K.,Hashimoto,K.,Yoshikawa,K.& Nakamura,T.: "Marked stimulation of growth and motility of human keratinocyte by hepatocyte growth factor." Exp.Cell Res.196. 114-120 (1991)

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      1991 Annual Research Report
  • [Publications] Mantesano,R.,Matsumoto,K.,Nakamura,T.& Orei L.: "I dentification of a fibroblastーderived epithelial epithelial morphogen as hepotocyte growth factor." Cell. 67. 901-908 (1991)

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      1991 Annual Research Report
  • [Publications] Mine,T.,Kojima,I.,Ogata,E.& Nakamura,T.: "Comparison of effects of HGF and EGF on cellular calcium in rat hepatocytes" Biochem.Biophys.Res.Commun.181. 1173-1180 (1991)

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      1991 Annual Research Report
  • [Publications] N.Yamamoto,S.Matsutani,Y.Yoshitake and K.Nishikawa: "Immunohistochemical locallization of basic fibroblast growth factor in A431 human epidermoid carcinoma cells." Histochemistry. 96. 479-485 (1991)

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      1991 Annual Research Report
  • [Publications] K.Yamada,Y.Yoshitake,H.Norimatsu and K.Nishikawa: "Roles of various growth factors in growth of human osteosarcoma cells which can grow in proteinーfree medium." Cell Struct.Funct.17. (1992)

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      1991 Annual Research Report
  • [Publications] Y.Yoshitake and N.Nishikawa: "Distribution of fibroblast growth factors in cultured tumor cells and their transplants." In Vitro Cell.Dev.Biol.28. (1992)

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      1991 Annual Research Report
  • [Publications] K.Matsumoto and T.Nakamura: "Hepatocyte growth factor : molecular structure,roles in liver regeneration,and other biological functions." Critical Reviews in Oncogenesis. 3. 27-54 (1992)

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  • [Publications] Shimizu,I.Ichihara,A.,& Nakamura,T.: "Hepatocyte growth factor in ascites from patients with cirrhosis." J.Biochem.109. 14-18 (1991)

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      1991 Annual Research Report
  • [Publications] Seki,T.,Hagiya,M.Shimonishi,M.,Nakamura,T.& Shimizu,S.: "Organization of the human hepatocyte growth factorーencoding gene." Gene. 102. 213-217 (1991)

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      1991 Annual Research Report
  • [Publications] Higuchi,O.& Nakamura,T.: "Identification and characterization of receptor for hepatocyte growth factor and change in the receptor in rat liver after partial hepatectomy and hepatitis." Biochem.Biophys.Res.Commun.176. 599-607 (1991)

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  • [Publications] Matsumoto,K.,Tajima,H.& Nakamura,T.: "Hepatocyte growth factor is a potent stimulator for human melanocytes DNA synthesis and growth." Biochem.Biophys.Res.Commun.176. 45-51 (1991)

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  • [Publications] Kinoshita,T.,Hirao,S.Matsumoto,K.& Nakamura,T.: "Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy." Biochem.Biophys.Res.Commun.177. 330-335 (1991)

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  • [Publications] H.Kondo,R.Matsuda and Y.Yonezawa: "Plateletーderived growth factor in combination with collagen promotes the migration of human skin fibroblasts into a denuded area of a cell monolayer." Experimental Cell Research.

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      1991 Annual Research Report
  • [Publications] K.Kaji,R.Hirai,K.Yamaoka,M.Matsuo: "Growth inhibition and cell shape alteration of human diploid fibroblasts due to transforming growth factorーβ1 in serumーfree media." Zoological Science. 8. 491-497 (1991)

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      1991 Annual Research Report
  • [Publications] Kuroda,Y.: "Plants and Health for All." Elsevier(The Netherlands), (1992)

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      1991 Annual Research Report
  • [Publications] 黒田 行昭: "新生理科学大系(第7巻)「発生・分化の生理学」" 医学書院(東京), 213-220 (1992)

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      1991 Annual Research Report
  • [Publications] Ide H.,Ohkubo Y.,Noji,S.,Taniguchi S.: "Retinoic acid and limb pattern formation in cell culture.in Developmental Patterning of the Vertebrate Limb(eds.Hinchliffe et al.)" Plenum, 105-113 (1991)

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      1991 Annual Research Report
  • [Publications] Y.Yoshitake,K.Matsuzaki and K.Nishikawa: "Derivation of monoclonal antibody to basic fibroblast growth factor and its application.Methods Enzymol.198" Academic Press(D.Barnes,J.P.Mather and G.H.Sato eds.), 148-157 (1991)

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      1991 Annual Research Report
  • [Publications] "3ーー〔(3・Chloamidopropyl)dimethylamnonio〕ー1ーpropane sulfonate as noncytotoxic atabilizing agent for growth factors.Methods Enzymol.198" Academic Press(D.Barnes,J.P.Mather and G.H.Sato eds.), 511-518 (1991)

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Published: 1992-03-31   Modified: 2016-04-21  

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