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Molecular Genetics of Micrbial Pathogenesis

Research Project

Project/Area Number 03304030
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 細菌学
Research InstitutionShinshu University

Principal Investigator

TERAWAKI Yoshiro  Shinshu Univ. Bacteriol. Progessor, 医学部, 教授 (10014333)

Co-Investigator(Kenkyū-buntansha) SASAKAWA Chihiro  Tokyo Univ. Inst. Med. Sci. Ass. Prof., 医科学研究所, 助教授 (70114494)
IKE Yasuyoshi  Gunma Univ. Wicrobiol. Professor, 医学部, 教授 (60125820)
ONISHI Yoshinari  Tokushima Univ. Bacteriol. Professor, 医学部, 教授 (10037400)
NAKAZAWA Teruko  Yamaguchi Univ. Microbiol. Professor, 医学部, 教授 (40053053)
AMAKO Kazunobu  Kyushu Univ. Bacteriol. Progessor, 医学部, 教授 (20078752)
井上 公蔵  大阪大学, 医学部, 教授 (10028300)
江崎 孝行  岐阜大学, 医学部, 教授 (90151977)
西渕 光昭  京都大学, 医学部, 助教授 (50189304)
Project Period (FY) 1990 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥23,400,000 (Direct Cost: ¥23,400,000)
Fiscal Year 1993: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1992: ¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 1991: ¥10,900,000 (Direct Cost: ¥10,900,000)
KeywordsBacterial pathogenesis / Toxin gene / Regulation of expression / Activation of toxin / Pathogenic plasmid / Shigella fiexneri / Pseudomonas aeruginosa / Vibrio cholerae / 病原細菌 / 病原因子 / 病原遺伝子 / 調節遺伝子 / DNA塩基配列 / 病原性プラスミド / 病原性ファージ / 病原細菌学 / 病原性の調節 / 調節遣伝子 / DNA塩基配例 / 溶原ファ-ジ
Research Abstract

As we prepared a report of this research group in detail in a booklet form, we summarized our results briefly as follows.
Microbial pathogenesis of which regulatory mechanism of expression is clarified or is progress.
The invasion-diffusion mechanisms of shigella bacilli. The spv virulence of Salmonella choleraesuis. The hemolysin of Vibrio species. The alkaline-protease of Pseudomonas aerug. The perfringolysin of Clostridium perfringens. The pili of Seratia marcescens.
microbial pathogemesis of which activation and/or translocation mechanism is clarified.
The cytotoxin of Pseudomonas aeruginosa. The hemolysin of Vibrio cholerae.The Vi antigen of Salmonella typhi. Tge hemolysin and leukocidin of Staphylococcus aureus. The hemolysin and bacteriocin of Enterococcus faecalis. The type C and E toxins of Clostridium botulinum.
Other Virulence factors.
The urease of Helicobacter pylori. The adherence of enteroaggregative Escherichia coli to human mucosa. The autoagglutination of chicken pathogenic Escherichia coli. The fimbiae of porphyromonas gingivalis. The neuraminidase of Bacteroides frag. The serum resistance donated by plasmid R100 TraT product.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (114 results)

All Other

All Publications (114 results)

  • [Publications] Matsui,H.: "Molecular mechanism of the regulation of expression of plasmid-encoded mouse bacteremia(mba) genes in Salmonella serovar Choleraesuis." Mol.Gen.Genet.236. 219-226 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hashomoto,Y.: "Complete nucleotide sequence and molecular characterization of viaB region encoding Vi antigen in Salmonella typhi." J.Bacteriol.175. 4456-4465 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shimizu,T.: "The virR gene,a member of a class of two component response regulators,regulates the production of perfringolysin O,collagenase and hemoagglutinin ---" J.Bacteriol.(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ozawa,T.: "Inactivation of gamma-hemolysin activity by the exogenous addition of monosialoganglioside G_<M1> in human erythrocyte." Biosci.Biotech.Biochem.(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nariya,H.: "Improved method for purification of leukocidin and gamma-hemolysin components from Staphylococcus aureus." Biosci.Biotech.Biochem.57. 2198-2199 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Rahman,A.: "Gamma-hemolysin genes in the same family with lukF and lukS genes in methicillin resistant Stapylococcus aureus" Biosci.Biotech.Biochem.57. 1234-1236 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nariya,H.: "The C-terminal region of S components of Stapylococcal leukocidin is essential for the biological activity of the toxin." FEBS lett.329. 219-222 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kamio,Y.: "The two Staphylococcal bi-component toxins,leukocidin and gamma-hemolysin,share one component in common." FEBS lett.321. 15-18 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tsuda,M.: "Genetic transformation in Helicobacter pylori." Microbiol.Immunol.37. 85-89 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Karita,M.: "Evaluation of methylene blue and triple therapy for eradication of Helicobacter pylori infection in the nude mouse model." Eur.J.Gastroenterol.Hepatol.5. S79-83 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Lin,Z.: "Vibrio parahemolyticus has a homolog of the Vibrio cholerae tox-RS operon of the thermolabile direct hemolysin gene." J.Bacteriol.175. 3844-3855 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujii,N.: "The complete nucleotide sequence of the gene encoding the nontoxic component of Clostridium botulinum type E progenitor toxin" J.Gen.Microbiol.139. 79-86 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujii,N.: "Similarity in nucleotide sequence of the gene encoding nontoxic component of botulinum toxin produced by toxigenic C.butyricum" Microbiol.Immunol.37. 395-398 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Moriishi,K.: "Two different types of ADP-ribosyltransferase C3 from Clostridium botulinum type D lysigenized organisms." Infect.Immun.61. 5309-5314 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ishii,T.: "Elastase gene expression in non-elastase producing Pseudomonas aeruginosa strains using novel shuttle vector systems." FEMS Microbiol.Lett.(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Suzuki,T.: "Identification and characterization of a chromosomal virulence gene,vacJ,required for intercellular spreading of Shigella --" Mol.Microbiol.(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tobe,T.: "Transcriptional control of the invasion regulatory gene virB of Shigella flexneri:" J.Bacteriol.175. 6142-6149 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nakata,N.: "The absence of a surface protease,ompT,determines the inter-cellular spreading ability of Shigella:the relationship ---" Mol.Microbiol.9. 459-468 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sasakawa,C.: "Eight genes in region-5 that form an operon are essential for invasion of epitherial cells by Shigella flexneri 2a." J.Bacteriol.175. 2334-2346 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sekizaki,T.: "DNA sequence of type 1 fimbrin,Fpull,gene from a chicken pathogenic Escherichia coli serotype 078." J.Vet.Med.Sci.55. 395-400 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hayashi,T.: "Molecular analysis of a cytotoxin-converting phage,φCTX,of Pseudomonas aeruginosa:structure of the attP-cos-ctx region ---" Mol.Microbiol.7. 657-667 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Xu,M.: "Demonstration and characterization of simultaneous production of a thermostable direct hemolysin(TDH/I) and a TDH-related ---" Infect.Immun.62. 166-171 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Iida,T.: "Cholera isolates in relation to the eigth pandemic." Lancet. 342. 926 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shinagawa,H.: "Cloning of the genes that control formation of the fimbrial colonization factor antigen III from an enterotoxigenic ----" Microbiol.Immunol.37. 689-694 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoh,M.: "Development of an enzyme-labeled oligonucleotide probe for the cholera toxin gene." J.Clin.Microbiol.31. 1312-1314 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naka,A.: "Characterization of two forms of hemagglutinin/protease produced by Vibrio cholerae non-01" FEMS Microbiol.Lett.98. 197-200 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshimura,F.: "Proteins with molecular mass of 50 and 80 kilodalton encoded by genes downstream from the fimbrilin gene(fimA) are ----" Infect.Immun.61. 5181-5189 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isogai,E.: "Fimbriae-specific immune response in various inbred mice inoculated with Porphyromonas gingivalis 381." Oral Microbiol.Immunol.8(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsui, H.: "Molecular mechanism of the regulation of expression of plasmid-encoded mouse" Mokec. Gen. Genet.236. 219-226 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hashimoto, Y.: "Complete nucleotide sequence and molecular characterization of viaB region" J.Bacteriol.175. 4456-4465 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shimizu, T.: "The virR gene, a member of a class of two component response regulators" J.Bacteriol.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nariya, H.: "Improced method for purificaation of leukocidin and gamma-hemolysin components" Biosci. Biotech. Biochem.57. 2198-2199 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kamio, Y.: "The two staphylococcal bi-component toxins, leukocidin and gamma-hemolysin" FEBS Lett.321. 15-18 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tsuda, M.: "Genetic transformation in Helicobacter Pylori." Micribiol. Immunol.37. 85-89 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Lin, Z.: "Vibrio parahamolyticus has a homolog of the Vibrio cholerae toxRS operon" J.Bacteriol.175. 3844-3855 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujii, N.: "The complete nucleotide sequence of the gene encoding the nontixic component of" J.Gen. Microbiol.139. 79-86 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ishii, T.: "Elastase gene exne expression in nonelastase producing Pseudomonas aeruginosa" FEMS Microbiol. Lett.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tobe, T.: "Transcriptional control of the invasion regulatory gene virB of Shigella Flexneri :" J.Bacteriol.175. 6142-6149 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sasakawa, C.: "Eight genes in region-5 that form an operon are essetial for invasion of" J.Bacteriol.175. 2334-2346 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sekizaki, T.: "DNA sequence of type 1 fimbrin, Fpull, gene from a chicken pathogenic Escherichia coli" J.Vet. Med. Sci.55. 395-400 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hayashi, T.: "Molecular analysis of a cytotoxin converting phage, phiCTX, of Pseudomonas aerug." Mol. Microbiol.7. 657-667 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Xu, M.: "Demonstration and characterization of simultaneous production of a thermostable" Infect. Immun.62. 166-171 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naka, A.: "Characterization of two forms of hemagglutinin/protease produced by Vibrio" FEMS Microbiol. Lett.98. 197-200 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshimura, F.: "Proteins with molecular mass of 50 and 80 kilodalton encoded by gene downstream" Infect. Immun.61. 5181-5189 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isogai, E.: "Fimbriae-specific immune response in various inbred mice inoculated with Porphyromonas gingivalis 381." Oral Microbiol. Immunol.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Matsui,H.: "Molecular mechanism of the regulation of expression of plasmid-encoded mouse bacteremia(mba) genes in Salmonella serovar Choleraesuis." Mol.Gen.Genet.236. 219-226 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hashomoto,Y.: "Complete nucleotide sequence and molecular characterization of viaB region encoding Vi antigen in Salmonella typhi." J.Bacteriol.175. 4456-4465 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Shimizu,T.: "The virR gene,a member of a class of two component response regulators,regulates the production of perfringolysin O,collagenase and hemoagglutinin ---" J.Bacteriol.(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ozawa,T.: "Inactivation of gamma-hemolysin activity by the exogenous addition of monosialoganglioside G_<Ml> in human erythrocyte." Biosci.Biotech.Biochem.(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nariya,H.: "Improved method for purification of leukocidin and gamma-hemolysin components from Staphylococcus aureus." Biosci.Biotech.Biochem.57. 2198-2199 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Rahman,A.: "Gamma-hemolysin genes in the same family with lukF and lukS genes in methicillin resistant Stapylococcus aureus." Biosci.Biotech.Biochem.57. 1234-1236 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Hayashi: "Molecular analysis of a cytotoxin-converting phage,φCTX,of P.aeruginosa:structure of the attp-cos-ctx region and integration into serine-" Molec.Microbiol(in press). 7(5). (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Rahman: "Molecular cloning and nucleotide sequence of leucocidin F-component hene(lukF)from methicillir resistant Staphylococcus aureus" Biochem.Biophys.Res.Commun.184. 640-646 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Sekizaki: "Acid-induced autoagglutination found in chicken pathogenic Escherichia coli strain" J.Vet.Med.Sci.54. 493-499 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Sekizaki: "Isolation and characterization of type 1 fimbriae from a chicken pathogenic Escherichia coli serotype O78" J.Vet.Med.Sci.54. 1145-1149 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Ike: "Hyperhemolitic phenomena associated with insertions of Tn916 into the hemolysin determinant of the Enterococcus faecalis plasmid pAD1" J.Bacteriol. 174. 1801-1809 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Ike: "Evidence that the hemolysin/bacteriocin phenotype of E.faecalis subsp.zymogenes can be determined by plasmids in different incompatibility group" J.Bacteriol.174. 8172-8177 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] N.Nakata: "Identification and characterization of virK,a virulence associated large plasmid gene essential for intercellular spreading of S.flexneri" Mol.Microbiol.6. 2387-2395 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Tobe: "vacB,a novel chromosomal gene required for expression of virulence genes on the large plasmid of Shigella flexneri" J.Bacteriol.174. 6359-6367 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] C.Sasakawa: "The large virulence plasmid of shigella" Cur.Top.Microbiol.Immunol.180. 21-44 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.TAmamoto: "Drug resistance and adherence to human intestines of enterroaggregative Escherichia coli" J.Infect.Dis.165. 744-749 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M Uchimura: "Production of hemagglutinins and pili by Vibriomimicus and its adherence to human and rabbit small intestines in vitro" FEMS Microbiol.Lett.91. 73-78 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Yamamoto: "Localized,aggregative and diffuse adherence to HeLa cells,plastic and human small intestines by Escherichia coli isolated from patients wuth--" J.Infect.Dis.166. 1295-1310 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Qi Ming-Shan: "Virulence phenotypes of Shigella flexneri 2a avirulent mutant 2450 can be complemented by the plasmid-coded.positive regulator virF gene" FEMS Microbiol.Lett.92. 217-222 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Takeuchi: "Structural gene and complete amino acid sequence of Vibrio alginolyticus collagenase" Biochem.J.281. 703-708 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Kanamoto: "Site-directed mutagenesis of Glu-141 and His-223 in P.aeruginosa elastase:catalytic activity processing and protective activity against ---" Infect.Inmmun.61(4). (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Watanabe: "Molecular cloning and expression of a major surface protein of prophylomonas gingivalis in Escherichia coli" FEMS Microbiol.Lett.42. 47-56 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] E.Isogai: "Fimbriae from Prophylomonas gingivalis induce chemiluminescence response of macrophages in different manner to its lipopolysaccharide" Bifidobacteria Microflora. 11. 39-43 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Kishishita: "Sequence variation in the theromstable direct hemo-lysis-related hemolysin(trh)gene of Vibrio parahemolyticus" Appl.Environ.Microbiol.58. 2449-2457 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Baba: "Examination by site-directed mutagenesis of the amino acid residues of the thermostable direct hemolysin of Vibrio parahemolyticus requered for---" Mjicrobiol.Pathogen.12. 279-287 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Nishibuchi: "Enterotoxigenicity of V.parahemolyticus with and without genes encoding thermostable direct hemolysin" Infect.Inmmun.60. 3539-3545 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] J.Tada: "Detection of the thermostable direct hemolysin gene(tdh)and the thermostable direct hemolysin related gene(tdh)of V.parahemolyticus by PCR" Mol.Cell.Probes. 6. 477-488 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Tamatsukuri: "Detection of a heat-labile entertoxin gene in enterotoxigeic Escherichia coli by densitometric evaluation using highly specific enzyme---" Eur.J.Clin.Microbiol.Inf.Dis.10. 1048-1055 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Yamamoto: "Enzyme-labeled oligonucleotide probes for detection of genes for thermostable direct hemolysin and TDH-related hemolysin of V.parahemolyticus" Can.J.Microbiol. 38. 410-413 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Miyagi: "Cholera diagnosed in clinical laboratory by hybridization" Lancet. 339. 988-989 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Naka: "Characterization of two forms of hemagglutinin/protease produced by Vibrio cholerae non-01" FEMS Microbiol.Lett.98. 197-200 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] N.Fujii: "Cloning and whole mucleotide sequence of the gene for the light chain component of botulinum type E toxin from C.butyricum strain BL6430 and---" Microbiol.Inmmunol.36. 213-220 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Tsuzuki: "The complete nucleotide sequence of the gene coding for the nontoxic nonhemagglutinin component of C.botulinum type C progenitor toxin" Biochem.Biophys.Res.Commun.183. 1273-1279 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] N.Yokosawa: "Inhibition of nonepinephrine secretion from dihitonin permialized PC12 cells by botulinum type D toxin" Toxicon. 30. 1555-1562 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Konishi: "Cytopathic effects of Helicobacter pylori on cultured mammalian cells" J.Med.Microbiol.37. 118-122 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Karita: "Establishment of new small animal model for human gastric Helicobacter pylori infection" Eur.J.Gastroenterol.Hepatol.Suppl.4. S25->29 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Tsuda: "Genetic transformation in Helicobacter pylori" Microbiol.Inmmunnol.37. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Mizunoe: "Identification and nucletode sequence of the gene determining the adhesin capacity of Serratia marcescense" J.Bacteriol.173. 3257-3260 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Danbara: "Effect of 50 kb-plasmid,pKDSC50,of Salmonella choleraesuis RF-1 strin on pig septisemia" J.Vet.Med.Sci.54. 1175-1178 (1992)

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      1992 Annual Research Report
  • [Publications] M.Emoto: "Induction of gamma/delta T-cell in murine salmonellosis by an avirulent but not by a vilurent strain of Salmonella choleraesuis" J.Exp.Med.176. 363-372 (1992)

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      1992 Annual Research Report
  • [Publications] H.Matsui: "Molecular mechanism of regulation of expressior of plasmid-encoded mouse bacteremia(mba) genes in Salmonella serovar choleraesuis" Mol.Gen.Genet.54. 219-216 (1993)

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      1992 Annual Research Report
  • [Publications] P.A.Gulig: "Molecular analysis of spv virulence genes of the Salmonella virulence plasmids" Mol.Microbiol.(1993)

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      1992 Annual Research Report
  • [Publications] 秋本 茂: "ノイラミニダーゼ遺伝子を利用したBacteroides tragilis診断用プローブの開発" 日本臨床1992年特別号感染症-遺伝子診断と分子疫学. 642. (1992)

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      1992 Annual Research Report
  • [Publications] N.Okada: "Virulence‐associated chromosomal loci of Shigella flexneri identified by random Tn5 insertion mutagenesis" Molecular Microbiology. 5. 187-195 (1991)

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      1991 Annual Research Report
  • [Publications] T.Toba: "Temperature‐regulated expression of invasion genes in Shigella flexneri is controlled through the transcriptio‐nal activation of the virB gene on the large plasmid" Molecular Microbiology. 5. 887-893 (1991)

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      1991 Annual Research Report
  • [Publications] N.Okada: "Construction of a physical map of the chromosome of Shigella flexneri 2a and the direct assignment of nine virulence‐associated loci identified by Tn5 insertions" Molecular Microbiology. 5. 2171-2180 (1991)

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      1991 Annual Research Report
  • [Publications] T.Yamamoto: "Characteristics of adherence of enteroaggregative Escherichia coli to human and animal mucosa" Infection and Immunity. 59. 3722-3739 (1991)

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      1991 Annual Research Report
  • [Publications] S.Fujimoto: "Low cost device for electrotransformation and its appliーcation to the highly efficient transformation of Escherichia coli and Enterococcus faecalis" Plasmid. 26. 131-135 (1991)

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      1991 Annual Research Report
  • [Publications] K.Ito: "Localization of IpaB protein in Escherichia coli Kー12 MC1061 strain carrying Shigella sonnei form I plasmid pss120" Microbiol.Immunol.35. 335-341 (1991)

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      1991 Annual Research Report
  • [Publications] Y.Yoshida: "Molecular cloning and characteization of form I antigen genes of Shigella sonnei" J.Gen.Microbiol.137. 867-874 (1991)

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  • [Publications] E.Tanaka: "Detection of elastase production in Escherichia coli with the elastase structural gene from several nonーelastase producing strains of Pseudomonas aeruginosa" J.Bacteriol.173. 6153-6158 (1991)

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  • [Publications] M.Nishioka: "Characterization of Porhyromonas gingivalis hemagglutinin as a protease" Biochem,Biophys.Res.Commun.178. 336-342 (1991)

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      1991 Annual Research Report
  • [Publications] K.Watanabe: "Molecular cloning and expression of a major surface protein(the 75ーKd protein) of Porhyromonas gingivalis" FEMS Microbiology Letters. (1992)

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      1991 Annual Research Report
  • [Publications] Y.Hashimoto: "Molecular Cloning of the ViaB region of Salmonella typhi" FEMS Microbiology Letters. 90. 53-56 (1991)

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      1991 Annual Research Report
  • [Publications] M.Nishibuchi: "Contribution of the tdhl gene of Kanagawa phenomenon positive Vibrio parahaemolyticus to production of extracellular thermostable direct hemolyisin" Microbial Pathogenesis. 12. (1992)

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      1991 Annual Research Report
  • [Publications] A.Terai: "Evidence for insertion sequenceーmediated spread of the thermostable direct hemolysin gene among Vibrio species" J.Bacteriol.173. 5036-5046 (1991)

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      1991 Annual Research Report
  • [Publications] T.Honda: "Characterization of a new thermostable direct hemolysin produced by a Kanagawaーphenomenon negative clonical isolates of Vibrio parahaemolyticus" Gen.Microbiol.137. 253-259 (1991)

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      1991 Annual Research Report
  • [Publications] K.Yamamoto: "Enzymeーlabeled oligonucleotide probes for detection of genes for thermostable direct hemolysin(TDH)and TDHーrelated hemolysin(TRH) of Vibrio parahaemolyticus" Can.J.Microbiol.(1992)

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      1991 Annual Research Report
  • [Publications] S.Tamatsukuri: "Detection of a heatーlabile enterotoxin gene in enteroーtoxigeneic Escherichia coli by densitometric evaluation using highly specific enzymeーlinked oligonucleotide probes" Eur.J.Clin.Microbiol.Infect.Dis.(in press). (1992)

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      1991 Annual Research Report
  • [Publications] 秋本 茂: "ノイラミニダ-ゼ遺伝子を利用したBacteroides fragilis診断用プロ-ブの開発" 日本臨床. (1992)

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      1991 Annual Research Report
  • [Publications] M.Karita: "New small animal model for human gastric Helicobacter pylori infection:success in both nude and euthymic mice" American J.Gastroenterogy. 86. 1596-1603 (1991)

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      1991 Annual Research Report
  • [Publications] H.Konishi: "Cytopathic effects of Helicobacter pylori on cultured mammalian cells" J.Med.Microbiol.(1992)

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      1991 Annual Research Report
  • [Publications] K.Fujita: "Binding sites for P and/or type 1ーpilated Escherichia coli in human ureter" J.Urol.146. 217-222 (1991)

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      1991 Annual Research Report
  • [Publications] P.Pramoonjago: "Role of TraT protein,an anticomplementary protein produced in Escherichia coli by R100 factor,in serum resistance" J.Immunol.148. 827-836 (1992)

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      1991 Annual Research Report
  • [Publications] P.Paramoonjago: "Bactericidal activity of C9ーdeficient human serum" J.Immunol.148. 837-843 (1992)

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      1991 Annual Research Report
  • [Publications] H.Matsui: "Positive regulator for the expression of Mba protein of the virulence plasmid,pKDSC50,of Salmonella choleraeーsuis" Microbial Pathogenesis. 10. 459-464 (1991)

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      1991 Annual Research Report
  • [Publications] R.Moriguchi: "A pathological study on the virulence of Salmonella choleraesuis associated with 50ーkilobase plasmid in mice" Int.J.Exp.Path.72. 163-169 (1991)

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      1991 Annual Research Report
  • [Publications] T.Hayashi: "Pseudomonas aeruginosa in Human Diseases" Karger,Basel, 6 (1991)

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      1991 Annual Research Report
  • [Publications] K.Okuda: "Pseudomonas;Biotransformation,Pathogenesis and Evolving Biotechnology" Acadimic Press, 9 (1990)

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      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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