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Co-operative research for the establishment of the presservation and the maintenance of the functional integrity in pulmonary and cardiopulmonary transplantation.

Research Project

Project/Area Number 03304038
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionInstitute of Development, Aging and Cancer, Tohoku University

Principal Investigator

FUJIMURA Shigehumi  Institute of Development, Aging and Cncer, Tohoku University. Professor, 加齢医学研究所, 教授 (40006078)

Co-Investigator(Kenkyū-buntansha) NAMIKAWA Syoji  Dpt.of Cardiovascular Surgery, Mie University, Associate Professor, 医学部, 助教授 (50024716)
KOMATSU Sakuzou  Dpt.of Cardiovascular Surgery, Sapporo Medical University, Professor, 教授 (00045329)
FURUSE Akira  Dpt.of Cardiovascular Surgery, Tokyo University, Professor, 医学部, 教授 (70010163)
TOMITA Masao  First Dpt. of Surgery Nagasaki University, Professor, 医学部, 教授 (70039808)
KATO Harufumi  Department of Surgery Tokyo Medical College, Professor, 教授 (20074768)
小柳 仁  東京女子医科大学, 教授 (90138884)
草川 實  三重大学, 医学部, 教授 (10046336)
田辺 達三  北海道大学, 医学部, 教授 (50000956)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 1993: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1992: ¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1991: ¥8,000,000 (Direct Cost: ¥8,000,000)
KeywordsLUNG TRANSPLANTATION / CARDIO-PULMONARY TRANSPLANTATION / PRESERVATION / DENERVATION / REJECTION / IMMUNOSUPPRESSION / PULMONARY EDEMA / 肺および心肺保存 / 保存臓器の評価 / 拒絶反応診断法 / 免疫抑制剤 / 移植後病態生理 / 移植適応基準
Research Abstract

1.Preservation : The extracellular-type solution proved to be superior to the intracellular-type solution in pulmonary preservation, which will make a change in the basic concept of the preserbative formula. In these experints, 24-hour preserved primate lungs with Ep4 solution were demonstrated to retain equal function compared with nonpreserved lungs after transplantation.
2.Diagnosis and treatment of the acute rejection : Gradual increase in IL-2 receptor positive T cells, gradual decrease in T4/T8 ratio in theBAL and the increment of expression in mRNAs of various cytokines obtained from lung allografts were observed in the course of progressive acute rejection in the model of rat lung transplantation. TNF was demonstrated to be likely an important cytokine in the mechanisms of tissue destruction in the process of acute rejection by the tolerant model of rat lung transplantation. The assessment of lymphocyte markers in the pleural effusion proved to be also helpful in the diagnosis of acute rejection with the primate model of lung ransplantation. The measurement of the water content in lung allografts with IH-MRI revealed the increase in values of SI and T2 in the early stage of pulmonary rejection. The expression of ICAM-1 on pulmonary epithelial cells was shown, suggesting these cells as target cells of CTLs in the course of acute rejection. FK506 was demonstrated to be an potent immunosuppressant in lung transplantation, as well.
3.Posttransplantation pulmonary edema : Substance-P and the supersensitivity of alpha receptors in the pulmonary vascular bed was suspected to have a major role in developing edema of lung allograft, suggesting pulmonary denervation as a critical factor in posttransplantation pulmonary edema, togather with cell-mediated mechanisms such as platelet activating factor.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (81 results)

All Other

All Publications (81 results)

  • [Publications] 松村 輔二: "日本猿を用いた肺移植の実験的研究-移植手技および免疫抑制法" 移植. 26. 117-126 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 松村 輔二: "ニホンザル肺移植における拒絶反応モニタリング" 移植. 26. 423-435 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takashi Kondo: "Vascular rejection and graft eosinophilia in rat lung allografts." J Surg Res. 51. 310-315 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takashi Kondo: "Evidence of complete tolerance in a model of rat lung allograft." Transplantation. 52. 928-931 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyasu Yokomise: "The effect of pulmonary arterial flow and positive end-expiratory pressure-on retrograde brondrial rnucosal flao." J Thorac Cardiovasr Surg. 101. 201-208 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中島 淳: "抗白血球モノクローナル抗体を用いたニホンザル肺移植拒絶反応の免疫" 日胸外会誌. 39. 1980-1986 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 赤嶺 晋治: "イヌ同種肺移植における気管支肺胞洗浄細胞のIa抗原発現に関する実験的検討-特にFK506による免疫抑制療法下において-" 移植. 3. 316-325 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中島 淳: "肺移植における水素電極方式による気管粘膜絶対血流量測定-ニホンザルによる実験的検討-" 移植. 27. 294-299 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirai T.: "The immunosuppressive effect of FK506 on canine lung transplantation" J Thorac Cardiovasc Surg. 103. 1127-1135 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hasegaw S: "Combination Use with subopfimal dosase of FK506 and cyclosporin A in canine lung trasplantation." J.Thorac Cardiovasc Surg. 104. 1340-1348 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takao Motoshi: "Histologic changes in donor bronchi may explain the reduced mucosal flow seen during acute lung allograft rejection." J Heart Lung Transplant. 11. 994-1000 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kawaguchi Akira: "Single lung transplantation in rats with fatal pulmonary hypertension." J Thorac Cardiovasc Surg. 104. 825-829 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 岡田 克典: "脱血心停止ドナー肺の24時間保存および同種移植に関する研究" 移植. 28. 38-45 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 山下 直巳: "保存肺の評価方法としての^1H-MRI(Proton Magnetic Resonance Imaging)の有用" 日本呼吸器外科学会雑誌. 7. 303 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Akira Kawaguchi: "Right heart decompression with a reversed interatrial shunt in rats with progressive pulmonary hypertension." Pulmonary Circulation Research. 55-60 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 関根 康雄: "移植肺浸潤リンパ球におけるdonor特異的細胞障害活性の解析" 移植. 28. 498 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 八田 光弘: "高肺血流による肺虚血再潅流時の微小循環不全に対するウリナスタチンの保護効果に関する検討" 医学のあゆみ. 166. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中島 淳: "ニホンザル同種肺移植におけるFK506の免疫抑制効果に関する研究" 日胸外会誌. 41. 1172-1183 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazuyoshi Shimada: "The possibility of lung transplantation from non-heart-beating danors following braindeath-Experimental study in canine model-" Transplant.Proc.(in printing). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hiroyuki Ohura: "Primate model of 24-hour pulmonary preservation for clinical application." Transplant.Proc.(in printing). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 岡田 克典: "脱血心停止ドナー肺の24時間保存および同種移植に関する研究" 移植. 28. 38-45 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Akira Kawaguchi: "Right heart decompression with a reversed interatrial shunt in rats with progressive pulmonary hypertension." Pulmonary Circulation Research. 55-60 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 中島 淳: "ニホンザル同種肺移植におけるFK506の免疫抑制効果に関する研究" 日胸外会誌. 41. 1172-1183 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takashi Hirai: "Prolonged lung allograft survival with a short course of FK506." J Thorac Cardiovasc Surg. 105. 1-8 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 近藤 丘: "肺移植の現状と展望" 臨床胸部外科. 12. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 半田 政志: "片側肺移植" 外科診療. 34. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 藤村 重文: "肺移植の現況" 日本内科学会雑志. 81. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 半田 政志: "肺移植の現況と諸問題" 医学のあゆみ. 160. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 近藤 丘: "肺移植臨床・研究の現況" 今日の移植. 5. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡田 克典: "脱血心停止Donor肺の24時間保存および同種移植に関する研究" 移植. 28. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 川原田 修義: "肺移植後の再潅流障害に対するPAFantagonistの効果に関する実験的研究" 札幌医学雑誌. 61. 71-83 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 平井 隆: "The immunosppressiue effect of FK-506 on canine lung transplantation" J.Thorac,Cardiovasc.Surg.103. 112-1135 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 長谷川 誠紀: "Combination use woth subopineal dosage of FK-506 and Cyclosporine A in.canime lung transplantation." J.Thorac,Cardiovasc.Surg.104. 1340-1348 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 乾 健二: "Bronchial circulation after experimental lung tansplantation-The effect of prednisolone on bronchial healing" J.Thorac.Cardiovasc.Surg.(1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 和崎 洋巳: "Laser Poppler Velocimetry(LDV)measurment on lung transplantation with bronchial arterial veconstruction in Canine System." Thoracic Cardiovascular Surgeon. 40. 182-184 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 平田 敏樹: "Omentopexy for cevasuclarigation of free tracheal graft in rat." Thoacic Cardiovasc Surgeon. 40. 178-181 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 川原 克信: "肺におけるreperfusion injuryとその防止-各種抗酸化剤の有用性に関する実験的検討ー" 日本血管外科学会雑誌. 1. 78-92 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田川 努: "Effects of platelet-activating factor antagonist TCV-309 on 24-h canine lung preservation" Cytoprotection and Cytobiology. 10. 129-137 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 赤嶺 晋治: "FK-506の肺移植時における気管支吻合部の粘膜血流量に及ぼす影響について" 気管支学. 4. 303-310 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 赤嶺 晋治: "イヌ同種肺移植における気管支肺胞洗浄細胞のIの抗原発現に関する実験的検討ー特にFK-506による免疫抑制療法下においてー" 移植. 3. 315-325 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 赤嶺 晋治: "イヌ同種肺移植におけるFK-506の免疫抑制効果に関する実験的検討" 日本呼吸器外科学会雑誌. 5. 21-27 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山口 豊: "肺移植における合併症ー原因と対策" 医学のあゆみ. 160. 490-492 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 中島 淳: "抗白血球モノクローナル抗体を用いたニホンザル肺移植拒絶反応の免易病理細識学的検討" 日本胸部外科学会雑誌. 39. 1980-1986 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 川口 章: "Single lung transplantation in rats with Chemically-induced pulmonary hypertension." J.Thovac.Cardiovasc.Surg.103. 483-489 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 川口 章: "Single lung transplantation in rats with fatal pulmonarg.hypertension." J.Thovac.Cardiovasc.Surg.104. 825-829 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 八田 光弘: "Heat and lung preseruation using a new solution;UCLA Formula" Transplant.Int. 5. 5370-5373 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 八田 光弘: "虚血肺のreperfusion injuryに関する実験的検討" 日本血管外科学会雑誌. 1. 83-86 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 八田 光弘: "死亡原因からみた心肺同時移植の問題点と考察" 今日の移植. 5. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 卜部 憲和: "単純浸漬肺保存における保存肺のPGI_2産生能の変化に関する検討" Therapeutic Research. 13. 502-504 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 藤沢 武彦: "Dose study on the immunosuppression of FK-506 in canine lung allotransplantation." Surgery Today.

    • Related Report
      1992 Annual Research Report
  • [Publications] 井上 孝史: "肺移植後早期肺水腫(reimplantation response)におけるSubstance Pの関与についての実験的研究" 三重医学. 36. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高尾 仁二: "Histological changes in donor bronchi may explain the reduced mucosal blood flow seen during acute lung allogaft vejection." J.Heart and hung Transplanitation. 11. 994-1000 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高尾 仁二: "Autoperfusion of the Heart and lungs for pressnation with preserving the bronchial circulation." J.Thoracic and Cardiovascular Surgerg. 104. 1748-1749 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 中島 淳: "肺移植における水素電極方式による気管粘膜絶対血流.血測定ーニホンザルによる実験的検討ー" 移植. 27. 294-299 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 和田 洋巳: "臓器移植に関連した諸問題:3.肺移植問題解決の実験的検討" 日本胸部外科学会雑誌. 40. 764-765 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 中島 淳: "抗白血球モノクロナ-ル抗体を用いたニホンザル肺移植拒絶反応の免疫" 日本胸部外科学会雑誌. 39. 1980-1986 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 八田 光弘: "心臓移植後の拒絶反応の診断" 今日の移植. 4. 281-288 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 八田 光弘: "心肺同時移植の問題点と展望" 「癌・免疫・栄養」誌. 5. 14-23 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 卜部 憲和: "保存肺のprostaglandin I_2産生能に関する実験的研究" 移植. 26. 358-362 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Katsunobu Kawahara: "An experimental study of canine isolated double lung transplantation" Acta Medica Nagasakiensia. 36. 55-60 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 川原 克信: "イヌにおける両肺分離移植" 今日の移植. 4. 631-635 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Yokomise: "Immunosuppressive effects of FK 506 in canine Iung transplantation" Transplantation Proceedings. 23. 3302-3303 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Yokomise: "The effect of pulmonary arterial flow and positive end‐expiratory pressure on retrograde bronchial mucosal blood flow" J Thoracic Cardiovase Surg.101. 201-208 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Aoki: "Bronchial circulation after experimental lung transplantation :the effect of direct revascularization of a bronchialatery" Eur J Cardio‐thorac Surg. 5. 561-565 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Fujino: "Scanning electronmicroscopic study of periheral bronchial membrane after canine bronchoplasty" J.Clin Electron Microscopy. 24. 184 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大久保 哲之: "マクロファ-ジおよびNK細胞の創傷治癒への関与についての実験的検討" 日本外科学会雑誌. 7. 897 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大坂 喜彦: "創傷治癒過程における免疫担当細胞の関与に関する研究" Progress in Medicine. 11. 368-369 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 川原 克信: "臓器移植の臨床検査" 臨床病理. 90. 67-81 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Honjyou: "IA expression and RNA content in BALF of allotransplantated lungs in dogs" Acta Medica Nagasakiensia. 36. 153-161 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Hisano: "Experimental study on reperfusion injury to warm ischemic lungーProtective effect of cv‐3611 and 2‐tochopherol on reperfusion lung" Acta Medica Nagasakiensia. 36. 243-251 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 川原田 修義: "肺移植後の再灌流障害に対するPAF antagonistの効果に関する実験的研究" 札幌医学雑誌. 61. 1-13 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Wada: "Dose response to FK 506 in canine lung transplantation" Transplantation Proceedings. 23. 3306-3307 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Hasegawa: "FK 506 and Cyclosporine:Effects and side effects in canine lung transplantation" Transplantation Proceedings. 23. 3304-3305 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大久保 哲之: "シクロスポリンの創傷治癒に及ぼす影響" 医学のあゆみ. 157. 661-662 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] A.T.Kawaguchi: "Effects of single‐lung transplantation on chemically induced pulmonary hypertension in the rat" Transplantation Proceedings. 23. 1220-1221 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松村 輔二: "日本猿を用いた肺移植の実験的研究ー移植手技及び免疫抑制法についてー" 移植. 26. 117-126 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takashi Kondo: "Vascular rejection and eosinophilia in rat lung allografts" Journal of Surgical Research. 51. 310-315 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松村 輔二: "ニホンザル肺移植における気管支肺胞洗浄による拒絶反応モニタリング" 今日の移植. 4. 443-448 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 半田 政志: "肺気腫患者に対する肺移植の現状" 日本医師会雑誌. 105. 34-36 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松村 輔二: "ニホンザル肺移植における拒絶反応モニタリング" 移植. 26. 423-435 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takashi Kondo: "Evidence of complete tolerance in a model of rat lung allograft" Transplantation. 52. 928-931 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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