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Physiological role of cytokines on homeostasis

Research Project

Project/Area Number 03404018
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionYamaguchi University

Principal Investigator

SAKATA Yoshiyuki (1993)  Yamaguchi University, Physiology, assistant prof, 医学部, 助手 (10034927)

村上 悳 (1991-1992)  山口大学, 医学部, 教授 (90040518)

Co-Investigator(Kenkyū-buntansha) WATANABE Tatsuo  Yamaguchi University, Physiology, associate prof, 医学部, 助教授 (60182929)
坂田 義行  山口大学, 医学部, 助手 (10034927)
森本 昭生  山口大学, 医学部, 助教授 (70127794)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥24,600,000 (Direct Cost: ¥24,600,000)
Fiscal Year 1993: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1992: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1991: ¥11,200,000 (Direct Cost: ¥11,200,000)
Keywordsinterleukin-1 / IL-1 / hybridization / OVLT / CRF / hyperthermia / hypertension / ACTH / CRF / インドメタシン / 精神性ストレス / カテコールアミン / 脳波 / 発熱反応 / 循環系活動 / in situ hybridization / α-hCRF / cRNA / サイトカイン / インタ-ロイキン1
Research Abstract

1) IL-1 production : the study was carried out to determine whether interleukin-1 (IL-1) production occurs in the rabbit organum vasculosum laminae terminalis (OVLT) during bacterial endotoxin (lipopolisaccharide, LPS), using in situ hibridization and immunohistochemical techniques. For the synthesis of antisense and sense RNA probes for insitu hybridization study, the rabbit IL-1betacDNA was subcloned. ^<35>S-labeled RNA probes were transcribed with RNA polymerase. The intravenous injection of LPS (4 mug/kg) caused the production of IL-1betamRNA in the OVLT during fever. Some cells ajacent to blood vessels in the brain and in the pia mater also showed IL-1betamRNA expression, although the expression was somewht lower than that seen in the OVLT.These results support the hypothesis that IL-1 is produced in the brain during fever.
2) IL-1 and CRF : the study was done to examine about the role of central corticontropin-releasing factor (CRF) in the development of caridiovascular and therma … More l responses induced by stress or by IL-1beta free-moving rats. Intracerebroventricular (icv) injection (10mug) of alpha-helical CRF (CRF receptor antagonist), significantly attenuated hypertension, tachycardia, and a rise in body temperature induced by cage-switch stress. However, icv injection of alpha-helical CRF had no effect on hypertension, tachycardia, of fever induced by prostagland in (PG) E_2. In contrast, icv injection of alpha-helical CRF attenuated hypertension, tachycardia, or fever induced by icv injection of IL-1beta. These results suggest that central CRF has an important role in the development of the cage-switsh stress-induced responses, but it does not seem to contribute to the hypertension, tachycardia, and fever induced by ip IL-1beta or by central PGE_2.
3) IL-1 and ACTH : the study was done to investigate the effect of pre-treatment with intraperitoneal (ip) injection of indomethacin, an inhibitor of prostaglandin systhesis, on psycological stress-induced responses including cardiovascular, thermoregulatory and hormonal responses in free-moving rats. Psychological stress was induced by cage-switch stress. After the rats wereplaced in the novel environment, blood pressure, heart rate and body temperature increased. Plasma levels of adrenocorticotropic hormone (ACTH) and PGE^2 were higher 30min after exposure to stress, in comparison the nornal levels. Indomethacin also suppressed the increases in the plasma levels of ACTH and PGE_2 induced by cage-switch stress. These results suggest that prostaglandins are involved in the development of hyperthermia and the ACTH response induced by psychological stress. Less

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (70 results)

All Other

All Publications (70 results)

  • [Publications] 森本 昭生: "持続的運動トレーニングと生体防衛反応" 体力研究. 77. 161-168 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 森本 昭生: "発熱の中枢神経機構" 山口老年医学総合研究所年報. 5. 27-37 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Morimoto: "The effect of prostaglandin E_2 on the body temperature of restrained rats" Physiol.Behav.50. 249-253 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Watanabe: "Prostaglandin E_2 is involved in adrenocorticotrophic hormone release during swimming exercise in rats" J.Physiol.(London). 433. 719-725 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Watanabe: "The effect of chronic exercise on the pituitary-adrenocortical response in conscious rats" J.Physiol.(London). 439. 691-699 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Morimoto: "Possible involvement of prostaglandins in psychological stress-induced responses in rats" J.Physiol.(London). 443. 421-429 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Sakata: "Fever and acute-phase response induced in rabbits by intravenous and intracerebroventricular injection of interleukin-6" Cytokine. 3. 199-203 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] N.C.Long: "The effect of physical restraint on IL-1β-and LPS-induced fever" Physiol.Behav.50. 625-628 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 村上 悳: "発熱の免疫生理学" 日本生理学雑誌. 54. 1-21 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 村上 悳: "運動と生体防衛反応" 運動生化学. 3,4. 162-170 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 森本 昭生: "運動ストレスのACTH反応機序" ホルモンと臨床. 40. 685-691 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Morimoto: "Does an increase in prostaglandin E_2 in the blood circulation contribute to a febrile response in rabbits?" Brain Res.Bull.29. 189-192 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] N.C.Long: "Systemic injection of TNF-α attenuates fever due to IL-1β and LPS in rats" Am.J.Physiol.263. R987-R991 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Watanabe: "Running training attenuates the ACTH responses in rats to swimming and cage-switch stress" J.Appl.Physiol.73. 2452-2456 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Sakata: "Effects of electrical stimulation or local anesthesia of the rabbit's hypothalamus on the acute phase response" Brain Res.Bull.31. 287-292 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Morimoto: "The central role of corticotrophin-releasing factor(CRF-41)in psychological stress in rats" J.Physiol.(London). 460. 221-229 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Effects of α- and β-adrenergic antagonists on the rise in body temperature induced by psychological stress in rats" Am.J.Physiol.264. R156-161 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] O.Yamashiro: "Febrile and metabolic tolerance to endotoxin and human recombinant interleukin-1β in rabbits" Am.J.Physiol.264. R1180-R1185 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Effects of a central CRF antagonist on cardiovascular and thermoregulatory response induced by stress or IL-1β" Am.J.Physiol.265. R834-R839 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Organum vasculosum laminae terminalis(OVLT)is a brain site to produce interleukin-1β during fever" Brain Res.618. 155-159 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Interleukin-1β production in the rabbit brain during endotoxin-induced fever" J.Physiol.(London). (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 村上 悳: "新生理学実習書" 南江堂, 114-117 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 村上 悳: "生気象学の事典" 朝倉書店, 200-201 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 村上 悳: "コアテキスト生理学(下)" 広川書店, 653-704 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 森本 昭生: "ブレインサイエンスIV" 朝倉書店, 62-79 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Integrative and cellular aspects of autonomic functions" John Libbey Eurotext(in press), (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Morimoto: "The effect of prostaglandin E_2 on the body temperature of restrained rats." Physiol.Behav.50. 249-253 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Watanabe: "Prostagland in E_2 is involved in adrenocorticotrophic hormone release during swimming exercise in rats." J.Physiol.(London). 433. 719-725 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Watanabe: "The effect of chronic exercise on the pituitary-adrenocortical response in conscious rats." J.Physiol.(London). 439. 691-699 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Morimoto: "Possible involvement of prostaglandins in psycological stress-induced responses in rats." J.Physiol.(London). 443. 421-429 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Sakata: "Fever and acute-phase response induced in rabbits by intravenous and intracerebroventricular injection of interleukin-6." Cytokine. 3. 199-203 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] N.C.Long: "The effect of physical restraint on IL-1beta- and LPS-induced fever." Physiol.Behav.50. 625-628 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Morimoto: "Does an increase in prostaglandin E_2 in the blood circulation contribute to a febrile response in rabbits?" Brain Res.Bull.29. 189-192 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] N.C.Long: "Systemic injection of TNF-alpha attenuates fever due to IL-1beta and LPS in rats." Am.J.Physiol.263. R987-R991 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Watanabe: "Running training attenuates the ACTH responses in rats to swimming and cage-switch stress." J.Appl.Physiol.73. 2452-2456 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Sakata: "Effects of electrical stimulation or local anesthesia of the rabbit's hypothalamus on the acute phase response." Brain Res.Bull.31. 287-292 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Morimoto: "The central role of corticotrophin-releasing factor (CRF-41) in psychological stress in rats." J.Physiol.(London). 460. 221-229 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Effects of alpha- and beta-adrenergic antagonists on the rise in body temperature induced by psychological stress in rats." Am.J.Physiol.264. R156-R161 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] O.Yamashiro: "Febrile and metabolic tolerance to endotoxin and human recombinant interleukin-1beta in rabbits." Am.J.Physiol.264. R1180-R1185 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Yamaguchi: "Organum vasculosum laminae terminalis (OVLT) in rabbit and rat : Topographic studies." J.Comp.Neurol.330. 352-362 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Effects of a central CRF antagonist on cardiovascular and thermoregulatory response induced by stress or IL-1beta." Am.J.Physiol.265. R834-R839 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Organum vasculosum laminae terminalis (OVLT) is a brain site to produce interleukin-1beta during fever." Brain Res.618. 155-159 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Interleukin-1beta production in the rabbit brain during endotoxin-induced fever." J.Physiol.(London). (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] T.Nakamori: "Interleukin-1beta production in the circumventricular organ during endotoxin fever." Integrative and cellular aspects of autonomic functions. ed. K.Pleschka & R.Gerstberger, John Libbey Eurotext Ltd., Paris. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Sakata: "Effects of electrical stimulation or local anesthesia of the rabbit's the acute phase response" Brain Res.Bull.31. 287-292 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] A.Morimoto: "The central role of corticotrophin-releasing factor (CRF-41) in psychological stress in rats" J.Physiol.(London). 460. 221-229 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Nakamori: "Effects of α- and β-adrenergic antagonists on the rise in body temperature induced by psychological stress in rats" Am.J.Physiol.264. R156-161 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] O.Yamashiro: "Febrile and metabolic tolerance to endotoxin and human recombinant interleukin-1β in rabbits" Am.J.Physiol.264. R1180-R1185 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Nakamori: "Effects of a central CRF antagonist on cardiovascular and thermoregulatory response induced by stress or IL-1β" Am.J.Physiol.265. R834-R839 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Nakamori: "Organum vasculosum laminae terminalis (OVLT) is a brain site to produce interleukin-1β during fever" Brain Res.618. 155-159 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Yamaguchi: "Organum vasculosum laminae terminalis (OVLT) in rabbit and rat:Topographic studies" J.Comp.Neurol.330. 352-362 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Nakamori: "Interleukin-1β production in the rabbit brain during endotoxin-induced fever" J.Physiol.(London). (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] T.Nakamori: "Integrative and cellular aspects of autonomic functions." K.Pleschka & R.Gerstberger (in press), (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tan, N. et al.: "Effect of running training on the blood glucose and lactate in rats during rest and swimming" Physiol. Behav.51. 927-931 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Morimoto, A. et al.: "Dose an increase in prostaglandin E2 in the blood circulation contribute to a febrile response in rabbits?" Brain Res Bull.29. 189-192 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Long, N. C. et al.: "Systemic injection of TNF-α attenuates fever due to IL-1β and LPS in rats." Am. J. Physiol.263. 987-991 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Watanabe, T. et al.: "Running training attenuates the ACTH responses in rats to swimming and cage-switch stress." J. Appl. Physiol.73. 2452-2456 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Morimoto, A. et al.: "The central role of corticotrophin-releasing factor (CRF-41) in psychological stress in rats." J. Physiol.460. 221-229 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nakamori, T. et al.: "Effects of α-and β-adrenergic antagonists on the rise in body temperature induced by psychological stress in rats." Am. J. Physiol.264. 156-161 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Morimoto, K. et al.: "Cardiovascular responses induced in free-moving rats by immune cytokines." J. Physiol.448. 307-320 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nakamori, T. et al.: "Effect of a central CRF antagonist on cardiovascula and thermoregulatory responses induced by stress or IL-1β" Am. J. Physiol.

    • Related Report
      1992 Annual Research Report
  • [Publications] Sakata, Y. et al.: "Effects of electrical stimulation or local anesthesia of the rabbits hypothalamus on the acute phase response." Brain Res. Bull.

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamashiro, O. et al.: "Febrille and metabolic tolerance to endotoxin and human recombinant interleukin-1β in rabbits." Am. J. Physiol.

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamaguchi, K. et al.: "Organum vasculosum laminae terminalis (OVLT) in rabbit and rat: Topographic studies." J. Comp. Neurol.

    • Related Report
      1992 Annual Research Report
  • [Publications] Watanabe,T.et al.: "ACTH response in rats during biphasic fever induced by interleukinー1" Am.J.Physiol.261. R1104-R1108 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Morimoto,A.et al.: "The effect of prostaglandin E_2 on the body temperature of restrained rats" Physiology & Behavior. 50. 249-253 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Long,N.C.et al.: "The effect of physical restraint on ILー1βーand LPSーinduced fever" Physiology & Behavior. 50. 625-628 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Morimoto,A.et al.: "Possible involvement of proトtaglandins in psychological stressーinduced responses in rats" J.Physiol.443. 421-429 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Watanabe,T.et al.: "ACTH release induced in rats by noradrenaline is mediated by proトtaキlandin E_2" J.Physiol.443. 431-439 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Long,N.C.et al.: "Intraperitoneal injections of prostaglandin E_2 attenuate hyperthermia induced by restraint or interleukinー1 in rats." J.Physiol.444. 363-373 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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