| Project/Area Number |
03404030
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyoto University |
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Principal Investigator |
KIMURA Jun Kyoto Univ., Medicine, Prof., 医学部, 教授 (30037444)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Akio Kyoto Univ., Med., Assis. Prof., 医学部, 助手 (90212761)
NAGAMINE Takashi Kyoto Univ., Med., Assis. Prof., 医学部, 助手 (10231490)
FUKUYAMA Hidanao Kyoto Univ., Med., Lecturer, 医学部, 講師 (90181297)
YONEKURA Yoshiharu Kyoto Univ., Med., Assoc. Prof., 医学部, 助教授 (60135572)
木村 淳 京都大学, 医学部, 教授 (10204976)
佐々木 和夫 京都大学, 医学部, 教授 (20025539)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥24,900,000 (Direct Cost: ¥24,900,000)
Fiscal Year 1993: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1992: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1991: ¥20,000,000 (Direct Cost: ¥20,000,000)
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| Keywords | voluntary movement / central control / noninvasive studies / movement-related cortical potentials / movement-related magnetic field / PET / regional cerebral blood flow / subdural recording / 硬膜下電極 / 局所脳血流量 |
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| Research Abstract |
Elucidation of generator sources of movement-related cortical potentials By subdural recording in patients with intractable epilepsy, the early electric potential starting about 2 s before the onset of voluntary finger movement (readiness potential) was found to be generated from the hand area of the supplementary motor area (SMA) and that of the primary motor area (M1), both bilaterally. The late negative slope preceding the movement onset by 300 ms was generated more from the contralateral SMA and M1.
Recording of movement-related magnetic field Magnetic field as sociated with voluntary finger movement was recorded by 7-as well as by 37-channel magnetometer, and the, generator sources of components immeiately preceding and following the movement onset were clarified.
Comparis on of simple and complex movements Scalp potentials preceding complex sequential finger movements were compared with those preceding simple simultaneous movements, and the former was found to be associated with more activation not only of SMA but also of bilateral Mlthan the latter.
Functional imaging by PET Simple and complex finger movements were compared by measuring an increase of regional cerebral blood flow with PET, and showed an evidence supporting the above electrophysiological findings.
Thus, these noninvasive studies clarified the important roles playd by not only SMA but also M1 in the planning and/or execution of voluntary finger movements in humans.
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