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Postoperative management and immunological study in living related liver trausplantation

Research Project

Project/Area Number 03404039
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyoto University

Principal Investigator

TANAKA Koichi  Kyoto Univ. Surg, Associate Professor, 医学部, 助教授 (20115877)

Co-Investigator(Kenkyū-buntansha) HONDA Kazuo  Kyoto Univ. Surg, Assistant, 医学部, 助手 (00209321)
INAMOTO Takashi  Kyoto Univ. Surg, Lecturer, 医学部, 講師 (10135577)
YAMAOKA Yoshio  Kyoto Univ. Surg, Professor, 医学部, 教授 (90089102)
小澤 和恵 (小澤 和惠)  京都大学, 医学部, 教授 (00026858)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1991: ¥8,500,000 (Direct Cost: ¥8,500,000)
Keywordsimmunosuppressant / Liver transplantation / Histocompatibility / living donor / Tacrolimus / Hla / 生体部分肝移植 / 動脈血中ケトン体比 / 拒絶反応 / 生体肝移植 / 血中ケトン体比 / HLA
Research Abstract

Ninety four children received living related liver transplantation (LRLT) from June 1990 to April 1994. It is well known that the large dose administration of immunosuppressant is accompanied by a high incidence of bacterial and viral infection and that steroids induce growth retardation. To reduce side effects and growth inhibition, we have been studying to minimized doges of immunosuppressants and develope optimal FK 506 dosing in LRLT.Steroids were withdrawn in 90% of recipients. A new protocol of FK 506 dosing was established with monitoring trough concentration using microparticle enzyme immunoassay method. It is sometimes said that the problem of immune reaction is not a crucial one to liver transplantation due to the liver's supposed to tolerance to immunity compared with heart and kidney transprantation. To evaluate the immunological role of the HLA class II matching between donor and recipient in LRLT, the postoperative clinical course was investigated. The matching of DRB1, DQB1 and DPB1 was revealed to have a beneficial effect in LRLT, while the matching of DQA1 was of a negative effect on graft function. The matching of HLAII should be reevaluated using reliable molecular method and deserve appropriate consideration in LRLT

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (45 results)

All Other

All Publications (45 results)

  • [Publications] K.Tanaka: "Complication management in living related liver transplantation" American J.Surg. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Tanaka: "Postoperative management based on the Redox theory in living related liver transplantation in children" J.Japanese Society of Pediatr.Surg. 29. 256-263 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Fujita: "Living related liver transplantation for biliary atresia" Clinical Transplantation. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Uemoto: "Experience with FK506 in living-related liver transplantation" Transplantation. 55. 288-292 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Tanaka: "Liver transplantation in children from living-related donors" Transplant.Proc. 25. 1084-1086 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Tokunaga: "Portal vein grafe in living related liver transplantation" S.G.O.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ozawa: "Living related donor liver transplantation" KARGER, 250 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Tonaka: "Complication management in living related liver trans plantation" Ame. J.Surg. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Tanaka: "Postopertive management based on the Redox theory in living related liver trausplantation in children" J.Jpn. Soc. Ped. Surg. (29). 256-263 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Fujita: "Living related liver trausplantation for biliary atresia" Clin. Transplant.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Uemoto: "Experience with FK506 in living related liver transplantation" Trausplant. (55). 288-292 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Tanaka: "Liver transplautation in children from living-related douors" Transplant. Prou. (25). 1084-1086 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Y.Tokunaga: "Portal vein graft in living related liver transpiontation" S.G.O. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ozawa: Living related donor liver transplautation. KARGER, 250 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Tanaka: "Complication management in living related liver transplantation" American J.Surg. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Tanaka: "Postoperative management based on the Redox theory in living related liver transplantation in children" J.Japanese Society of Pediatr.Surg. 29. 256-263 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] S.Fujita: "Living related liver transplantation for biliary atresia" Clinical Transplantation. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] S.Uemoto: "Experience with FK506 in living-related liver transplantation" Transplantation. 55. 288-292 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Tanaka: "Liver transplantation in children from living-related donors" Transplant.Proc.25. 1084-1086 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Y.Tokunaga: "Portal vein graft in living related liver transplantation" S.G.O. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Ozawa: "Living related donor liver transplantation" KARGER, 250 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Koichi Tanaka: "Complication management in lining related liver Transplan Tation" American J.Surg.

    • Related Report
      1992 Annual Research Report
  • [Publications] Koichi Tanaka: "Postoperative management based on the Redox the ory in living related liven transplan tation in child ren" J.Japanese Society of Pediat.Sung.

    • Related Report
      1992 Annual Research Report
  • [Publications] Koichi Tanaka: "Surgical Techniques and innovations in living related liven transplantation" Ann.Sung.217. 82-91 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Koichi Tanaka: "Living related liven Transplantaion" Transplant.Proc.24. 2252-2253 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Koichi Tanaka: "Liven Transplantion From living related chonors" Transplant.Proc.25. 1084-1086 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Shinji clamoto: "Infectious complications in living related liven Trans pleahtatin" J.Pediat.Surg.

    • Related Report
      1992 Annual Research Report
  • [Publications] Yukihiko Tokunaga: "Living related liver Transplantation Across ABO blood groups with FK506 and OKT_3" Transplat Intennational.

    • Related Report
      1992 Annual Research Report
  • [Publications] Shinji Uemoto: "Experience with FK506 in living related liver transplantation" Transplantation. 55. 288-292 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yasutsugu Takata: "Artena Ketone boby ratio and glucose Administration as an enetgy substrate in velation to changes in ketone body concenfration after LRLT" Transplantation.

    • Related Report
      1992 Annual Research Report
  • [Publications] Akira Tanaka: "Short term changer in lipid and protain metabolism in living related einen transplantation" Amer.J.Sung.

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Hauashi: "Ejjcts of cold prescenvation on sleatotic graft viability in rot liver Transplantation" Transplantation.

    • Related Report
      1992 Annual Research Report
  • [Publications] Yasuyuki Shimahara: "Analysis if the risk and operative staese For donors in living nelated pavtial liven transplantation" Transplantation. 54. 983-988 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田中 紘一: "生体肝移植におけるレシピエント手術手技の諸問題" 日本移植学誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 田中 紘一: "生体部分肝移植の今後の展望" 医学のあゆみ.

    • Related Report
      1992 Annual Research Report
  • [Publications] 田中 紘一: "生体部分肝移植におけるレシピエントの手術法" 小児外科. 25. 281-286 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田中 紘一: "生体肝移植をめぐる問題点" 医学のあゆみ. 164. 491-494 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田中 紘一: "生体肝移植の現況" 外科診療. 34. 895-901 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田中 紘一: "生体肝移植" 日本臨床. 49. 2725-2731 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 田中 紘一: "FK506の肝移植への応用" 今日の移植.

    • Related Report
      1991 Annual Research Report
  • [Publications] 上本 伸二: "Experience with FK506 in living relateel liven transplantation" Transplan tation.

    • Related Report
      1991 Annual Research Report
  • [Publications] 小澤 和惠: "an appraisal of Pediatric Liver Transplantation.from living relatives" Ann.Surg.

    • Related Report
      1991 Annual Research Report
  • [Publications] 田中 紘一: "肝移植後のウイルス感染対策" 臨床と研究. 69. 789-793 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 田中 紘一: "肝移植(生体部分肝移植)の適応と術前後の管理" 小児外科. 23. 555-560 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 田中 紘一: "Biliary atresia" Icom associates Inc, 301 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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