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The Mechanism of Trace-element Accumulation into Tooth Enameloid/Enamel and Its Evolutionary Changes.

Research Project

Project/Area Number 03404053
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

AOKI Harumi (1992-1994)  The Nippon Dental University, Dept.of Dentistry, Assistant professor, 歯学部, 助教授 (50150925)

須賀 昭一 (1991)  日本歯科大学, 歯学部, 教授 (50060405)

Co-Investigator(Kenkyū-buntansha) SATO Atsushi  The Nippon Dental University, Dept.of Dentistry, Assistant, 歯学部, 助手 (30225916)
TAYA Yuji  The Nippon Dental University, Dept.of Dentistry, Assistant, 歯学部, 助手 (30197587)
OGAWA Masaaki  The Nippon Dental University, Dept.of Dentistry, Lecturer, 歯学部, 講師 (40095097)
青木 春美  日本歯科大学, 歯学部, 講師 (50150925)
Project Period (FY) 1991 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥35,500,000 (Direct Cost: ¥35,500,000)
Fiscal Year 1994: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1991: ¥28,500,000 (Direct Cost: ¥28,500,000)
KeywordsTooth / Enamel / Enameloid / Trace elements / Fluoride / Iron / Phylogeny / Evolution
Research Abstract

In the past studies, it was postulated that accumulation of iron or other trace elements in fish enameloid should be related to feeding habits of the fishes. However, the results of the present investigation yielded no supportive evidence for those previous concept. The present studies indicate that the mineral phase of enameloid in both cartilagineous and bony fishes is most adequately characterized as fluoridated carbonatoapatites. However, the degree of fluoridation, Fe accumulation, and carbonation of the apatite lattice vary among the species and, within a species, at different developmental stages. It is of interest to consider that the observed accumulation of fluoride and iron may reflect the composition of ancient body fluid or in the mineralizing milieu. The overall results suggest that the accumulation of iron and fluoride into fish enameloid realized in the Actinopterygian lineage. In light of the evidence obtained, the origin of the F accumulation into tooth enameloid can be traced back to the cladistian stage of Actinoperygian evolution, while that of high fluoride concentration to the Neopterygian stage. Most likely, the iron accumulation mechanism has been evolved prior to the F accumulation, probably emerging with the brachiopterygian or relevant species. Indeed, there are no teleostean fishes which exhibits a combination of high F and low Fe, except for sharks. Thus it seems likely that the mechanisms of F and Fe accumulation have been developed independently with different evolutionary backgrounds and that its accumulation mechanisms have been buried in the evolutionary process from fishes through amphibian to mammals. At present, it is most likely that iron accumulation into developing enameloid has been lost during the evolution from the Acanthuridae to the Tetraodontoidei, based on the finding that a shatp contrast with respect to the iron content was obtained between the enameloid of the Tetraodontoidei and Acanthuridae.

Report

(5 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (43 results)

All Other

All Publications (43 results)

  • [Publications] Miake,Y.: "Ultsratructural Studies on Crystal Growth of Enameloid Minerals in Elasmobranch and Teleost Fish." Calcif Tissue Int. 48. 204-217 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 大滝義晴: "サイクロフォスファマイドの連続注射による歯質の形成異常" 歯学. 79. 1393-1426 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 瀬戸口浩彰: "コルヒチンの一回注射によるラット切歯形成期エナメル質の石灰化異常" 歯基礎誌. 34. 291-306 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga,S.: "Iron in the Enameloid of Perciform Fish." J Dent Res. 71. 1316-1325 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 須藤豊哉: "副甲状腺焼灼による形成期エナメル質石灰化進行像の変化" 歯基礎誌. 34. 391-424 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 田谷雄二: "HEBPの長期経口投与によるエナメル質形成異常" 歯基礎誌. 34. 560-594 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 須賀昭一: "魚の歯の中のフッ素" 日本歯科評論. 5-7 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 田谷雄二: "ビンクリスチン1回注射によるラット切歯エナメル芽細胞の変化:成熟期後期エナメル芽細胞の剥離と嚢胞形成" 歯基礎誌. 35(印刷中). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga,S.: "Hypoplasia and Hypomineralization of tooth enamel." J Pareopatholoqy,Monographic Publications In;Recent Contributions to the Study of Enamel Developmental Defects.269-292 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 杉山雅章: "HEBPの長期経口投与によるラット臼歯の歯周組織変化" 歯学. 80. 988-1012 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga,S.: "Fluoride and Iron Concentrations in the Enameloid of Lower Teleostean Fishes" J Dent Res. 72. 912-922 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga,S.: "Evolution of Fluoride and Iron Concentrations in the Enameloid of Fish Teeth." In;Mechanisms and Phylogeny of Mineralization in Biological Systems (Biomineralization '90). 439-446 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga,S.: "Fluoride and Iron Concentrations in the Teeth of Primitive Bony Fishes (Osteichthyes)" In;Hard Tissue Mineralization and Demineralization. 17-32 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 須賀昭一: "バイオミネラリゼイション研究と私" シュプリンガーサイエンス. 6. 13-16 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga,S.: "Mechanisms and Phylogeny of Mineralization in Biological Systems(Biomineralization '90)" Springer Verlag,Tokyo, 517 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga,S.: "Hard Tissue Mineralization and Demineralization" Springer Verlag,Tokyo, 197 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Miake, Y.: "Ultrastructural Studies on Crystal Growth of Enameloid Minerals in Elasmobranch and Teleost Fish." Calcif Tissue Int. 48. 204-217 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Ohtaki, Y.: "Disturbed Formation of Dental Hard Tissues Caused by Continuous Injection of Cyclophosphamide." SHIGAKU. 79. 1393-1426 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Setoguchi, H.: "Disturbed Mineralization of the Developing Enamel of Rat Incisor Induced by Single Injection of Colchicine." Jpn J Oral Biol. 34. 291-306 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga, S.: "Iron in the Enameloid of Perciform Fish." J Dent Res. 71. 1316-1325 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sudo, T.: "Changes of Progressive Mineralization Pattern of Developing Enamel caused by Cautery of Parathyroid Gland." Jpn J Oral Biol. 34. 391-424 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Taya, Y.: "Disturbed Enamel Formation Induced by the Oral Administration of HEBP." Jpn J Oral Biol. 34. 560-594 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga, S.: "Hypoplasia and Hypomoneralization of Tooth Enamel." J Pareopathology. 269-292 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Sugiyama, M.: "Changes of Periodontal Tissues of Rat Molar Induced by Long-Term Oral Administration of HEBP." SHIGAKU. 80. 988-1012 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga, S.: "Fluoride and Iron Concentrations in the Enameloid of Lower Teleostean Fishes." J Dent Res. 72. 912-922 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga, S.: "Evolution of Fluoride and Iron Concentration in the Enameloid of Fish Teeth." In : Mechanisms and Phylogeny of Mineralization in Biological Systems, Springer Verlag, Tokyo. 439-446 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga, S.: "Fluoride and Iron Concentrations in the Teeth of Primitive Bony Fishes(Osteichthyes)." In : Hard Tissue Mineralization and Demineralization. Springer Verlag, Tokyo. 17-32 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Taya, Y.: "Morphologic Changes in Rat Incisor Ameloblasts by a Single Injection of Vincristine ; Sub-ameloblastic Cyst Formation at the Late-Maturation Stage" Jpn J Oral Biol. 35 : (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga, S.: Mechanisms and Phylogeny of Mineralization in Biological Systems(Biomineralization '90). Springer Verlag, Tokyo, 517 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Suga, S.: Hard Tissue Mineralization and Demineralization.Springer Verlag, Tokyo, (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 田谷雄二: "ビンクリスチン1回注射によるラット切歯エナメル芽細胞の変化:成熟期後期エナメル芽細胞の剥離と嚢胞形成" 歯科基礎医学会雑誌. 37(印刷中).

    • Related Report
      1994 Annual Research Report
  • [Publications] Aoba T.: "Mechanistic understanding of enamel mineralization under fluoride regime" Connective Tissue Research,. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Suga,Y.Taki and M.Ogawa: "Fluoride and Iron Concentrations in the Enameloid of Lower Teleostean Fish" Journal of Dental Research. 72. 912-922 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] S.Suga and Y.Taki: "Fluoride and Iron Concentrations in the Teeth of Primitive Bony Fishes(Osteichthyes)" S.Suga,N.Watabe(Eds.),Springer-Verlag,Tokyo,Hard Tissue Mineralization and Demineralization. 17-32 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Suga,Y.Taki and M.Ogawa: "Iron in the Enameloid of Perciform Fish" Journal of Dental Research. 71. 1316-1325 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 瀬戸口 浩彰,小野 夫倶子,北島 俊秀,須賀 昭一: "コルヒチンの一回注射によりラット切歯形成期エナメル質の石灰化異常" 歯科基礎医学会雑誌. 34. 291-308 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田谷 雄二,須賀 昭一: "HEBPの長期経口投与によるエナメル質形成異常" 歯科基礎医学会雑誌. 34. 560-594 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 杉山 雅章,田谷 雄二,佐藤 睦,須賀 昭一: "HEBPの長期経口投与によるラット臼歯の歯周組織変化" 歯学. 80. 988-1012 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Suga,Y.Taki and M.Ogawa: "Fluoride and Iron Concentrations in the Enameloid of Lower Teleostean Fish" Journal of Dental Research. 72. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Suga,N.Watabe: "Hard Tissue Mineralization and Demineralization" Springer-Verlag,Tokyo, 197 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Suga,Y.Taki,K.Wada and M.Ogawa: "Evolution of Fluoride and Iron Concentrations in the Enameloid of Fish Teeth" Mechanisms and Phylogeny of Mineralization in Biological Systems S.Suga,H.Nakahara(Eds.),Springerーverlag,Tokyo. 439-446 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Suga,Y.Taki and M.Ogawa: "Iron in the Enameloid of Perciform Fishes" Journal of Dental Research.

    • Related Report
      1991 Annual Research Report
  • [Publications] 瀬戸口 浩彰,小野 夫倶子,北島 俊秀,須賀 昭一: "コンヒチンの一回注射によるラット切歯形成期エナメル質の石灰化異常" 歯科基礎医学会雑誌.

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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