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Study on development of new bactericidal-biocompatible material for conserving infected pulp.

Research Project

Project/Area Number 03404055
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionNiigata University

Principal Investigator

IWAKU Masaaki  Niigata University, School of Dentistry, Professor, 歯学部, 教授 (70013927)

Co-Investigator(Kenkyū-buntansha) YAMAGA Masahiro  Niigata University, School of Dentistry, Assistant Professor, 歯学部, 助手 (10260548)
KOTA Kohichi  Niigata University, School of Dentistry, Associate Professor, 歯学部, 助教授 (90018755)
HOSHINO Etsuro  Niigata University, School of Dentistry, Professor, 歯学部, 教授 (90124619)
宇佐美 祐一  新潟大学, 歯学部, 助手 (10193856)
Project Period (FY) 1991 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥31,900,000 (Direct Cost: ¥31,900,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1993: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1992: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1991: ¥20,700,000 (Direct Cost: ¥20,700,000)
KeywordsMetronidazol / Infected pulp / Tissue regeneration / Obligate Anaerove / Bactericidal-biocompatible material / alpha-Tricalcium phosphate / 偏性嫌気性菌 / 歯髄保護 / 抗菌性生体材料 / メトロダニ-ル
Research Abstract

This study was projected for developing the most effective new bactericidal-biocompatible material to conserve the infected pulp tissue.
Following results were obtained :
1. A mixture of Ciprofloxacin, Metronidazole and Cefaclor showed the complete bactericidal efficacy against all of the bacteria in the infected pulp tissue.
2. The antibacterial mechanism of metronidazole was revealed the investigation of the metabolism of phenylalanine and leucine of anaerobic bacteria.
3. alpha-tricalcium phosphate (alpha-TCP) showed the superior biocompatibility as the direct capping material on the histopathological study using adult monkeys.
4. The histopathological study showed that alpha-TCP containing mixed antibacterial drugs effectively disinfected the bacterially contaminated pulpal lesions of adult monkeys without destroying any of the sound pulp tissue and formed the hard tissue barrier covering the exposed pulpal surface.
5. alpha-TCP containing mixed antibacterial drugs completely disinfected human caries lesions in vitro and in situ studies.
6. In the in vivo study of the volunteer peoples, artificially exposed pulp tissue was convered by the hard tissue barrier formation without destroying any of the sound pulp tissue, when alpha-TCP containing mixed antibacterial drugs was applied on the exposed pulp tissue.
7. In the clinical study of the volunteer patients, almost cases of the infected pulp, especially young, has been kept without any of the pulpectomy or pulpotomy by the application of the mixed antibacterial drugs added to alpha-TCP and covered with time by the hard tissue barrier.
8. This work is now in progress.

Report

(5 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] E.Hoshino: "Bacterial inxasion of non-exposed dental pulp." International Endodontic Journal. 25. 2-5 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Sato: "Bactericidal efficacy of a mixture of ciprofloxacin,metronidazole,minocycline and rifampicin against bacteria of carious and endodontic lesions of human deciduous teeth in vitro." Microbial Ecology in Health and Disease. 5. 171-177 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鮎川幸雄: "生体親和性直接覆髄剤に対するヒト歯髄の反応." 日本歯科保存学雑誌. 36. 1146-1159 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 鮎川幸雄: "生体親和性抗菌性直接覆髄剤に対するヒト歯髄の反応 ー混合抗菌剤の改良についてー." 日本歯科保存学雑誌. 37. 643-651 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiba K: "Histological observations of hard tissue barrier formation in amputated dental pulp capped with a-Tricalcium phosphate containing calcium hydroxide." Endodontics & Dental Traumatology. 10. 113-120 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.A.Hamid: "The metabolism of phenylalanine and leucine by a cell suspension of eubacterium brachy and the effects of metronidazole on metabolism." Archs Oral Biol. 39. 967-972 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Kunihiko Yoshiba: "Effects of antibacterial capping agents on dental pulps of monkeys mechanically exposed to oral microflora." Journal of Endodontics. 21. 16-20 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] E.Hoshino: "Bacterial inxasion of non-exposed dental pulp." International Endodontic Journal. 25 (1). 2-5 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] T.Sato: "Bactericidal efficacy of a mixture of ciprofloxacin, metronidazole, minocycline and rifampicin against bacteria of carious and endodontic lesions of human deciduous teeth in vitro." Microbial Ecology in Health and Disease. 5. 171-177 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Ayukawa: "Pulpal Response of Human Teeth to Biocompatible Pulp-capping Agent." Japan.J.Conserv.Dent.36 (4). 1146-1159 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Y.Ayukawa: "Pulpal Response of Human Teeth to Antibacterial Biocompatible Pulp-capping Agent-Improvement of Mixed Drugs-." Japan.J.Conserv.Dent.37 (2). 643-651 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiba K.: "Histological observations of hard tissue barrier formation in amputated dental pulp capped with alpha-Tricalcium phosphate containing calcium hydroxide." Endod Dent Traumatol. 10. 113-120 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] M.A.Hamid: "The metabolism of phenylalanine and leucine by a cell suspension of eubacterium brachy and the effects of metronidazole on metabolism." Archs Oral Biol. 39 (11). 967-972 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiba K.: "Effects of antibacterial capping agents on dental pulps of monkeys mechanically exposed to oral microflora." J Endodon. 21 (1). 16-20 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Yoshiba K: "Histological observations of hard tissue barrier formation in amputated dental pulp capped with a-Tricalcium phosphate containing calcium hydroxide." Endodontics & Dental Traumatology. 10. 113-120 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.A.Hamid: "The metabolism of phenylalanine and leucine by a cell suspension of eubacterium brachy and the effects of metronidazole on metabolism." Archs Oral Biol. 39. 967-972 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kunihiko Yoshiba: "Effects of antibacterial capping agents on dental pulps of monkeys mechanically exposed to oral microflora." Journal of Endodontics. 21. 16-20 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kunihiko Yoshiba: "Histological observations of hard tissue barrier formation in amputated dental pulp capped with α-tricalcium phosphate containing calcium hydrodxide" Endodontics & Dental Traumatology. 10(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kunihiko Yoshiba: "Effects of anibacterial capping agents on dental pulps of monkeys mechanically exposed to oral microflora" Journal of Endodontics. 20(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 鮎川幸雄: "生体親和性直接覆髄剤に対するヒト歯髄の反応" 日本歯科保存学雑誌. 36. 1146-1159 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 鮎川幸雄: "生体親和性抗菌性直接覆髄剤に対するヒト歯髄の反応" 日本歯科保存学雑誌. 37(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 子田 晃一: "三種混合抗菌剤混入が新型αTCPセメントの物性及び操作性に及ぼす影響について" 日本歯科保存学雑誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 岩久 正明: "生体親和性抗菌性直接覆髄剤の口腔内開放歯髄に対する効果" 日本歯科保存学雑誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 岩久 正明: "生体親和性直接覆髄剤に対するヒシ歯髄の反応" 日本歯科保存学雑誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 星野 悦郎: "新組成抗菌剤の人ウ蝕細菌への効果に関する研究" 日本歯科保存学雑誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 宇佐美 祐一: "人為的細菌感染させた動物歯髄への抗菌性材料の治療効果に関する研究" 日本歯科保存学雑誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 子田 晃一: "試作抗菌性覆髄剤の磯作性に関する研究" 日本歯科保存学雑誌 発表予定.

    • Related Report
      1991 Annual Research Report
  • [Publications] 宇佐美 祐一: "試作抗菌性材料の歯髄創面における硬組織形成能に関する研究" 日本歯科保存学雑誌 発表予定.

    • Related Report
      1991 Annual Research Report
  • [Publications] 子田 晃一: "試作抗菌性覆髄剤の臨床応用に関する研究" 日本歯科保存学雑誌 発表予定.

    • Related Report
      1991 Annual Research Report
  • [Publications] 宇佐美 祐一: "試作抗菌性覆髄剤の生体組織塗布後の物性変化に関する研究" 日本歯科保存学雑誌 発表予定.

    • Related Report
      1991 Annual Research Report
  • [Publications] 星野 悦郎: "人感染歯髄中の各種細菌の同定と試作抗菌性材料の抗菌効果に関する研究" 日本歯科保存学雑誌 発表予定.

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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