Studies on Silk fibroin as Biomaterials
| Project/Area Number |
03453130
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
蚕糸学
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| Research Institution | TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY |
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Principal Investigator |
HIRABAYASHI Kiyoshi Faculty of Technology, Professor, 工学部, 教授 (90021146)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Mitsuo Faculty of Technology, Research Assistant, 工学部, 助手 (00015041)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1993: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1992: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1991: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Artificial Skin / Molded silk / Blending / Membrane / chitosan / Polymer / GMA / Bones / 絹フィブロイン / 生体適合性 / β構造 / グリシジルメタクリレート / バイオ素材 / β型分子形態 / キャスト膜 / 絹複合膜 / 絹フイブロイン / キヤストフイルム / β化 / 強伸度 / フイブロイン・キトサン混合膜 |
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| Research Abstract |
It is difficult to produce practically applicable artificial skins and molded materials. Recently it has been reoprted that the physical properties of the former decreased with the increase of the beta-structure. Therefore, an attempt has been made in order to produce a practically applicable artificial skin having better physical properties by blending of the silk with other natural polymers. A composite membrance of silk and chitosan can be produced which have network structures and better mechanical properties due to the good miscibility of these two polymers. The silk powder produced by the acid decomposition was found to be suitable for producing artificial bones when the silk powder was treated for 10 minutes under a pressure of 1000 kg/cm^2 at 150ﾟC.Sufficient strength and water resistability could ont be achieved with the silk powder alone. Therefore, glycidylmethacrylate (GMA) was blended with silk and practically applicable molded material was successfully produced. It was found that the application of molded silk as a substitute of bones is possible.
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Report
(4 results)
Research Products
(25 results)
