| Project/Area Number |
03453154
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | University of Tokyo |
|---|
Principal Investigator |
SHUDO Koichi Univ Tokyo Prof., 薬学部, 教授 (50012612)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHWADA Tomo Univ. Tokyo Assist. Prof., 薬学部, 助手 (20177025)
ENDO Yasuyki Univ Tokyo Assoc. Prof., 薬学部, 助教授 (80126002)
|
|---|
| Project Period (FY) |
1991 – 1992
|
| Project Status |
Completed (Fiscal Year 1992)
|
| Budget Amount *help |
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1992: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1991: ¥4,500,000 (Direct Cost: ¥4,500,000)
|
|---|
| Keywords | Friedel-Crafts reaction / Iminiumbenzenium ion / Carbenium ion / Super acid / Trifluoromethanesulfonic acid / Gattermannreaction / Gattermann-Koch reaction / 反応機構 / ベンゼン / フリーデルクラフト反応 / ジカチオン / 求電子試薬 / フリ-デルクラフト反応 / アセチル化 / カチオン / ガッタ-マン反応 / エチレンジカチオン / オキソニウムカチオン |
|---|
| Research Abstract |
Researches on di-and tri- cationic species as electrophiles in the reaction of benzene were performed. Dications and Trications propoded in the work are:
1.Iminium-benzenium dications
2.Diphenylmethylcations bearing a protonated carboxylic acid.
3.Diprotonated nitrostyrenes and nitroethylenes.
4.N,N-Diprotonated cinnamaldimines.
5.O,O-diprotonated cinnamaldehydes.
6.Diprotonated cyanides
7.triprotonated nitroacetic acid and their esters.
8.Diprotonated ketones.
9.Protnated acyl cations.
These novel species can be prepared in a strong acid and readily react with benzene. These results generalized the participation of di- or tricationic species in electrophilic aromatic substitution of benzene.
|
