| Project/Area Number |
03454131
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | INSTITUTE FOR ENZYME RESEARCH |
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Principal Investigator |
INOUE Isao 徳島大学, 酵素科学研究センター, 助教授 (80001973)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥4,300,000 (Direct Cost: ¥4,300,000)
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| Keywords | Potassium ion / Homeostasis / Glial-neuronal interaction / Squid giant axon / Isolation / Schwann cell / Calcium channel / Calcium activated / Potassium channel / カルシウムイオン / 神経細胞 / パッチクランプ法 |
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| Research Abstract |
The K^+ homeostasis was found to be maintained at least three processes. The fast and medium processed were revealed to be due to lateral diffusion and transversal diffusion through microtubular system across the Schwann cell, respectively from the electrophysiological and electron microscopic studies. The slow process was found to be related to ionic mechanism of the Schwann cell by whole cell-patch clamp studies on enzymatically isolated Schwann cells. We found at least three voltage sensitive currents ; inward Ca^<2+> -sensitive outward K^+ current, and inwardly rectifying current that appeared at hyperpolarizing voltages.
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