• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on roles of poly(ADP-ribose) in cell differentiation and carcinogenesis

Research Project

Project/Area Number 03454159
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

UEDA Kunihiro  Kyoto Univ. Fac. of Med Dept. of Lab. Med. Assoc. Prof., 医学部, 助教授 (00027070)

Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsPoly(ADP-ribose) / Enzyme inhibitor / ADP-ribosyltransferase / Enzyme activator / Cell differentiation / Teratocarcinoma / Vesnarinone / Bloom syndrome / ポリ(ADPーリボース) / ADPーリボシルトランスフェラーゼ / ポリ(ADPーリボシル)化 / ポリ(ADPーリボ-ス)シンテタ-ゼ / 阻害剤 / 細胞分化の誘導 / テラトカルシノ-マ細胞 / モノ(ADPーリボシル)トランスフェラ-ゼ / ビタミンK / カルシウムイオン
Research Abstract

1. Inhibitors of ADP-ribosylation: From among >400 organic compounds, we found many strong inhibitors of poly(ADP-ribose) synthetase. Part of them proved to be inhibitory to mono(ADP-ribosyl)transferases.
2. Activators of poly(ADP-ribosyl)ation: We found activation of poly(ADP-ribose) synthetase by metal ions, organic solvents, polyanions, chelators, and carboline compounds.
3. Tumor cell differentiation: We found the action of 4-hydroxyquinazoline and other new inhibitors to induce endothelial differentiation of teratocarcinoma EC cells in culture.
4. Vesnarinone: We found vesnarinone and its derivatives to inhibit poly(ADP-ribose) synthetase and induce EC cell differentiation into neuronal or glial cells.
5. Calcium ion: We found correlation between poly(ADP-ribose) synthetase activity and Ca^<++> concentrations in differentiation-induced epidermal transformed cells.
6. Bloom syndrome: We found an abnormally low activity of poly(ADP-ribose) synthetase in lymphocytes of low-SCE type Bloom syndrome.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Ikai,K.: "Poly(adenosine diphosphate-ribose)Synthetase in transformed mouse epidermal cells in culture." Acta Histochem.Cytochem.24. 251-255 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 上田 國寛: "ポリ(ADP-リボース)代謝酵素系と生物学的機能" ビタミン. 65. 213-226 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Banasik,M.: "Specific inhibotors of poly(ADP-ribose)Synthetase and mono(ADP-ribosyl)tranceferase" J.Biol.Chem.267. 1569-1575 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Banasik,M.: "Inhibition of poly(ADP-ribose)Synthetase activity by dimethyl Sulfoxide" J.Enz.Inhib.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Miyahara,T.: "Hyperthermic enhancement of cytotoxicity and increased uptake of cis-diaminedechloroplatinum(II)into cultured human esphageal cancer cell" Jap.J.Cancer Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ikemoto,M.: "Development of an efficient ELISA system for human liver arginase and its clinical application" Clin.Chem.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kido,T.: "ADP-Ribosylation Reactions" Springer-Verlag, 410 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ueda,K.: "Recent Advancesin Cellular and Molecular Biology,Vol.6" Peeters Press, 320 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ikai, K., et al.: "Poly(adenosine diphosphate-ribose) synthesis in transformed mouse epidermal cells in culture" Acta Histochem. Cytochem.24. 251-255 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ueda, K.: "Metabolism and biological functions of poly(ADP-ribose)" Vitamins (in Japanese). 65. 213-226 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Banasik, M., et al.: "Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl) transferase" J. Biol. Chem.267. 1568-1575 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Banasik, M., et al.: "Inhibition of poly(ADP-ribose) synthetase activity by dimethyl sulfoxide" J. Enz. Inhib.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Miyahara, T., et al.: "Enhancement of cytotoxicity and increased uptake of cis-diamine dichloroplatinum (II) into cultured human esophageal cancer cells" Jap. J. Cancer Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ikemoto, M., et al.: "Development of an efficient ELISA system for human liver arginase and its clinical applications" Clin. Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kido, T., et al.: "Improved assays of poly(ADP-ribose) metabolizing enzymes" Springer-Verlag, "ADP-Ribosylation Reactions". 460 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Banasik, M., et al.: "Specific inhibitors of poly(ADP-ribose) synthetase" Springer-Verlag, "ADP-Ribosylation Reactions". 460 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ueda, K., et al.: "Molecular and cellular basis of poly(ADP-ribose) functions" Peeters Press, "Recent Advances in Cellular and Molecular Biology". 320 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ueda K., et al.: "Biological roles of mono-and poly(ADP-ribosyl)ation" Center for Academic Publications Japan, "Proceedings of the 1st International Congress on Vitamins and Biofactors in Life Science". 606 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ueda, K., et al.: "Inhibition of poly(ADP-ribose) synthetase activity tryptophan metabolites" Fujita Health University by Press, "Advances in Tryptophan Research 1992". 446 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ikai,K.: "Poly(adenosine diphosphate-ribose)synthetase in formed mouse opidermal cells in culture." Acta Histochem. Cytochem.24. 251-255 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 上田 國寛: "ポリ(ADPーリボース)代謝酵素系と生物学的機能" ビタミン. 65. 213-226 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Banasik,M.: "Specific inhibitors of poly (ADPーribose)synthetase and mono(ADPーribosyl)transferase." J.Biol.Chem.267. 1569-1575 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Banasik,M.: "Inhibition of poly(ADP-ribose)synthetase activity by dimethyl sulfoxide." J.Enz.Inhib.

    • Related Report
      1992 Annual Research Report
  • [Publications] Miyahara,T.: "Hyperthermic enhancement of cytotoxicity and increased uptake of as-diaminedichloroplatinum(2)into cultured human esphageal cancer cells." Jap.J.Cancer Res.

    • Related Report
      1992 Annual Research Report
  • [Publications] Ikemoto,M.: "Development of an efficient ELISA system for human liver arginase and its clinical applications" Clin.Chem.

    • Related Report
      1992 Annual Research Report
  • [Publications] Kido,T.: "ADP-Ribosylation Reactions" Springer-Verlag, 410 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ueda,K.: "Recent Advances in Cellular and Molecular Biology,Vol.6" Peeters Press, 320 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ikai,K.: "Poly(adenosine diphosphateーribose) synthesis in transformed mouse epidermal cells in culture" Acta Histochem.Cytochem.24. 251-255 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 上田 國寛: "ポリ(ADPーリボ-ス)の代謝酵素系と生物学的機能" ビタミン. 65. 213-226 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Banasik,M.: "Specific inhibitors of poly(ADPーribose) synthetase and mono(ADPーribosyl)transferase" J.Biol.Chem.38. 1569-1575 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ueda,K.: "Molecular and cellular basis of poly(ADPーribose) functions" Cell.Mol.Biol.38. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Miyahara,T.: "Enhancement of cytotoxicity of cisーdiaminedichloroplatinum(II)to human esophageal cancer cells by hyperthermia" Cancer Res.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Banasik,M.: "Inhibition of poly(ADPーribose) synthetase activity by dimethylsulfoxide" J.Enz.Inhib.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kida,T.: "ADPーRibosylation Reactions" SpringerーVerlag, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Banasik,M.: "ADPーRibosylation Reactions" SpringerーVerlag, (1992)

    • Related Report
      1991 Annual Research Report

URL: 

Published: 1992-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi