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Identification and Functional Analysis of Protein Kinase C-Related Gene

Research Project

Project/Area Number 03454164
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionYOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

OHNO Shigeo  YCU Sch. Med. Dept. Mol. Bio. Professor, 医学部, 教授 (10142027)

Co-Investigator(Kenkyū-buntansha) MIZUNO Keiko  YCU Sch. Med. Dept. Mol. Bio. Assistant Professor, 医学部, 助手 (90221803)
HIRAI Shu-ichi  YCU Sch. Med. Dept. Mol. Bio. Assistant Professor, 医学部, 助手 (80228759)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1992: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1991: ¥3,700,000 (Direct Cost: ¥3,700,000)
KeywordsProtein kinase C / PKC-related enzymes / Phorbol esters / Transcriptional Activation / Kinase / Diacylglycerol / プロテインキナ-ゼC / ホルボ-ルエステル / キナ-ゼ / 上皮組織
Research Abstract

We have isolated cDNA clones encoding a new PKC family member PKC lambda. PKC lambda shows closest amino acid sequence identity with PKCzata(70% in total) and is structurally classified into the third sub-family of PKC. Expression of cDNAs for PKCzata and lambda in COS cells revealed the similarity in their biochemical properties in that both on them do not possess phorbol ester binding activities and that their kinase activities are not dependent on Ca, diacylglycerols, and phorbol esters. These structural and biochemical properties of PKCzata and lambda indicates that they are not the cellular receptor to diacylglycerols nor phorbol esters. Thus this subfamily is termed as aPKC (atypical PKC) subfamily.
In order to examine the functional differences of aPKC (zata, lambda) from conventional cPKC (alpha,beta,gamma) and from nPKC (delta,epsilon,eta,rheta), the effect of the overexpression of each of the members on the transcriptional activation of several cis-acting elements were examined. Overexpression of aPKC resulted in an enhancement of the transcriptional activation of TPA-response element (TRE) in response to serum but not TPA. Overexpression of cPKC or nPKC resulted in an enhanced transcriptional activation of a TPA-response element in response to TPA.
The results clearly indicate that aPKC is a novel family of signal transducing protein kinases which transmit a signal to TRE. Furthermore, the mode of the activation of aPKC differs from cPKC and nPKC. Further experiments to identify the serum factor which activates aPKC revealed that aPKC is activated in cells in response to tyrosine-kinase receptor activation implying the presence of a novel signaling pathway in cells from Tyr-kinase receptor to aPKC activation.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (61 results)

All Other

All Publications (61 results)

  • [Publications] Hata,A.,Akita,Y.,Suzuki,S.and Ohno,S.: "Functional divergence of protein kinase C(PKC) family members;PKCγ differs from PKC α,β II,and nPKC ω in its competence to mediate 12-O-tetradecanoyl phorbol 13-acetate(TPA)-responsive transcriptional activation through a TPA-response element." J.Biol.Chem.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osada,S.,Hashimoto,Y.,Nomura.,S,Konno.,Y.,Chida,K.,Tajima,O.,Kubo,K.,Akomoto,K.,Koizumo,H.,Kitamura,Y.,Suzuki,K.,Ohno.,S.and Kuroki,T.: "Predominant expression of novel protein kinase C η,aCa2+-independent isoform of protein kinase C in epithelial tissues,in association with epithlial differentiation." Cell Growth&Differentiation.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kim,H-M.,Hirota,S.,Onoue,H.,Hirata,T.,Suzuki,K.,Ohno,S.,Kuroki,T.,Kitamura,Y.and Nomura,S.: "Localization and development expression of a novel protein kinase C δ gene." Developmental Brain Research. 70. 239-244 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osada,S.,Mizuno,K.,Saido,T.C.,Suzuki,K.,and Ohno,S.: "A new member of the protein kinase C family,nPKCθ,predominantly expressed in skeletal muscle." Molec.Cell.Biol.12. 3930-3938 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Maizels,E.T.,Miller,J.B.,Cutler Jr.,R.E.,Jackiw,V.,Camey,E.M.,Mizuno,K.,Ohno,S.,and Hunzicker-Dunn,M: "Estrogen modulates Ca2+-independent lipid-stimulated kinase in thr rabbit corpus leteum of pseudopregnancy.Identification of lureal estrogen-modulated lipid-stimulated kinase as δ-C-kinase." J.Biol.Chem.267. 17061-17068 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Gruber,J.R.,Ohno,S.,and Niles,R.M.: "Increased expression of PKC α plays a key role in retinoic acid induced melanoma differentiation." J.Biol.Chem.267. 13356-13360 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hata,A.,Ohno,S.,and Suzuki,K.: "Transcriptional activation of the gene for the large subunit of human m-calpain by 12-o-tetradecanoyl-phorbol-13-acetate." FEBS Letters. 304. 241-244 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Niino,Y.,Ohno,S.and Suzuki,K.: "Positive and negative regulation of the transcription of human protein Kinase C β gene." J.Biol.Chem.267. 6158-6163 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saido,T.C.,Mizuno,K.,Konno,Y.,Osada,S.,Ohno,S.and Suzuki,K.: "Purification and characterization of protein Kinase C ε(nPKCε) from rabiit brain." Biochemistry. 31. 482-490 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 水野 恵子、大野 茂男: "プロテインキナーゼCアイソザイムの同定" 実験医学. 11(3). 163-169 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamaoka,K.,Ohno,S.,Kawasaki,H.and Suzuki,K.: "Overexptession of A β-Garactoside binding protein causes transformation of BALB3T3 Fibroblast cells." Biochem.Biophys-Res.Commun.179. 272-279 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Mizuno,K.,Kubo,K.,Saido,T.C.,Akita,Y.,Osada,S.,Kuroki,T.,Ohno,S.and Suzuki,K.: "Structure and properties of a ubiquitouslyexpressed protein Kinase C,nPKCδ." Eur.J.Biochem.202. 931-940 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yu,G.,Ahmad,S.,Aquino,A.,Fairchild,C.R.,Trepel,J.B.,Ohno,S.,Suzuki,K.,Turuo,T.,Cowan,K.H.and Glazer,R.I.: "Transfection with protein Kinase Cα confers increased multidrug resistance to MCF-7 cells expressing p-Glycoprotein." Cancer Communications.3. 181-189 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Konno,Y.,Natsumeda,Y.,Nagai,M.,Yamaji,Y.,Ohno,S.,Suzuki,K.and Weber.G.: "Expression of human IMP dehydrogenase types I and II in escherichia coli and distribution in human normal lymphocytes and leukemic cell lines." J.Biol.Chem.266. 506-509 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 水野 恵子、大野 茂男: "プロテインキナーゼCアイソザイムの同定" 実験医学. 9(17). 2271-2276 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 水野 恵子、大野 茂男: "プロテインキナーゼCの多様性と細胞情報伝達の制御" 最新医学. 46(9). 1877-1883 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 大野 茂男、秋田 朗子、羽田 明子、秋本 和憲、水野 恵子、長田 真一、鈴木 紘一: "Protein Kinase C isozymeと細胞機能" 神経と免疫研究. 4. 14-19 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohno,S9: "Diversity and specificity of multiple protein kinase C." Progress in Endocrinology,Parthenon Press.,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 大野 茂男: "C-キナーゼとシグナル伝達" 腎臓学Key Notes,東京医学社, 2 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohno,S.,Akita,Y.,Hata,A.,Osada,S.,Kubo,K.,Konno,Y.,Akimoto,K.,Mizuno,K.,Saido,T.,Kuroki,T.and Suzuki,K.: "Structural and functional diversities of a family of signal trasducing protein Kinases,protein Kinase C family;two distinct classes of PKC,conventional cPKC and novel nPKC." Advances in Enzyme Regulation,Pergamon Press., 7 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 大野 茂男: "Cキナーゼによるシグナル伝達ーその普遍性と多様性ー発がんとがん細胞" がんのバイオサイエンス3(黒木登志夫編)東大出版会, 17 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 大野 茂男: "Cキナーゼ" Annual Review細胞生物学 中外医学社, 12 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohno,S.: "Diversity and specificity of multiple protein kinase C." Progress in Endocrinology, Parthenon Press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hata, A., Akita, Y., Suzuki, S. and Ohno,S.: "Functional divergence of protein kinase C(PKC) family members; PKCgamma differs from PKCalpha,betaII, and nPKC_<epsilon> in its competence to mediate 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element." J.Biol.Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osada,S., Hashimoto, Y., Nomura., S. Konno., Y., Chida, K., Tajima, O., Kubo, K., Akomoto, K., Koizumo, H., Kitamura, Y., Suzuki, K., Ohno, S. and Kuroki,T.: "Predominant expression of novel protein kinase Ceta,a Ca^<2+>-independent isoform of protein kinase C in epithelial tissues, in association with epithlial differentiation." Cell Growth & Differentiation.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kim, H-M., Hirota, S., Onoue, H., Hirata, T., Suzuki, K., Ohno, s., Kuroki, T., Kitamura, Y. and Nomura,S.: "Localization and development expression of a novel protein kinase C delta gene." Developmental Brain Research.70. 239-244 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osada, s., Mizuno, K., Saido, T. C., Suzuki, K., and Ohno.S.: "A new member of the protein kinase C family, nPKCrheta, predominantly expressed in skeletal muscle." Molec. Cell. Biol. 12. 3930-3938 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Maizels, E. T.,, J.B., Cutler Jr., R. E., Jackiw, V., Carney, E. M., Mizuno, K., Ohno, S., and Hunzicker-Dunn, M.: ":Estrogen modulates Ca^<2+>-independent lipid-stimulated kinase in the rabbit corpus leteum of pseudopregnancy. Identification of lureal estrogen-modulated lipid-stimulated kinase as delta-C-kinase." J. Biol. Chem.267. 17061-17068 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Gruber, J.RO., Ohno, S., and Niles, R.M.: "Increased expression of PKCalpha plays a key role in retinoic acid induced melanoma differentiation." J. Biol. Chem. 267. 13356-13360 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hata, A., Ohno, S., and Suzuki, K.: "Transcriptional activation of the gene for the large subunit of human m-calpain by 12-o-tetradecanoyl-phorbol-13-acetate." FEBS Letters.304. 241-244 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Niino, Y., Ohno, S. and Suzuki, K.: "Positive and negative regulation of the transcription of the human protein Kinase Cbeta gene." J. Biol. Chem.267. 6158-6163 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saido, T. C., Mizuno, K., Konno, Y., Osada, S., Ohno, S. and Suzuki, K.: "Purification and characterization of protein Kinase Cepsilon(nPKCepsilon) from rabbit brain." Biochemistry.31. 482-490 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohno, S., Akita, Y., Hata, A., Osada, S., Kubo, K., Konno, Y., Akimoto, K., Mizuno, K., Saido, T., Kuroki, T. and Suzuki, K.: ":Structural and functional diversities of a family of signal transducing protein Kinases, protein Kinase C family ; two distinct classes of PKC, conventional cPKC and novel nPKC." Advances in Enzyme Regulation, Pergamon Press.31. 287-303 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamaoka, K. Ohno, S., Kawasaki, H. and Suzuki, K.: "Overexpression of Abeta-Garactoside binding protein causes transformation of BALB3T3 Fibroblast cells." Biochem. Biophys-Res. Commun.179. 272-279 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Mizuno, K., Kubo, K., Saido., T. C., Akita, Y., Osada, S., Kuroki, T., Ohno, S. and Suzuki, K.: "Structure and properties of a ubiquitously expressed protein Kinase C,nPKCdelta." Eur. J. Biochem.202. 931-940 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yu, G., Ahmad, S., Aquino, A., Fairchild, C. R., Trepel, J. B., Ohno, S., Suzuki, K., Turuo, T., Cowan K., H. and Glazer, R. I.: "Transfection with protein Kinase Calpha confers increased multidrug resistance to MCF-7 cells expressing p-Glycoprotein." Cancer Communications.3. 181-189 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Konno, U., Natsumeda, Y., Nagai, M., Yamaji, Y., Ohno,S., Suzuki, K. and Weber. G.: "Expression of human IMP dehydrogenase types I and II in escherichia coli and distribution in human normal lymphocytes and leukemic cell lines." J. Biol. Chem.266. 506-509 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hata,A.,Akita,Y.,Suzuki,S.and Ohno,S.: "Functional divergence of protein kinase C(PKC)family members;PKCγ differs from PKC α,βII,and nPKC ε in its competence to mediate 12-O-tetradecanoyl phorbol 13-acetate(TPA)-responsive transcriptional activation through a TPA-response element." J.Biol.Chem.

    • Related Report
      1992 Annual Research Report
  • [Publications] Osada,S.,Hashimoto,Y.,Nomura.,S,Konnno.,Y.,Chida,K.,Tajima,O.,Kubo,K.,Akomoto,K.,Koizumo,H.,Kitamura,Y.,Suzuki,K.,Ohno.,S.and Kuroki,T.: "Predominant expression of novel protein kinase C η,aCa2+-independent isoform of protein kinase C in epithelial tissues,in association with epithlial differentiation." Cell Growth & Differentiation.

    • Related Report
      1992 Annual Research Report
  • [Publications] Kim,H-M.,Hirota,S.,Onoue,H.,Hirata,T.,Suzuki,K.,Ohno,S.,Kuroki,T.,Kitamura,Y.and Nomura,S.: "Localization and development expression of a novel protein kinase C δ gene." Developmental Brain Research.

    • Related Report
      1992 Annual Research Report
  • [Publications] Osada,S.,Mizuno,K.,Saido,T.C.,Suzuki,K.,and Ohno,S.: "A new member of the protein kinase C family,nPKCθ,predominantly expressed in skeletal muscle." Molec.Cell.Biol.12. 3930-3938 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Maizels,E.T.,Miller,J.B.,Cutler Jr.,R.E.,Jackiw,V.,Camey,E.M.,Mizuno,K,.Ohno,S.,and Hunzicker-Dunn,M.: "Estrogen modulates Ca2+-independent lipid-stimulated kinase in the rabbit corpus leteum of pseudopregnancy.Identification of lureal estrogen-modulated lipid-stimulated kinase as δ-C-kinase." J.Biol.Chem.267. 17061-17068 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Gruber,J.R.,Ohno,S.,and Niles,R.M.: "Increased expression of PKC α plays a key role in retinoic acid induced melanoma differentiation." J.Biol.Chem.267. 13356-13360 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hata,A.,Ohno,S.,and Suzuki,K.: "Transcriptional activation of the gene for the large subunit of human m-calpain by 12-o-tetradecanoyl-phorbol-13-acetate." FEBS Letters. 304. 241-244 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Niino,Y.,Ohno,S.and Suzuki,K.: "Positive and negative regulation of the transcription of the human protein Kinase C β gene." J.Biol.Chem.267. 6158-6163 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Saido,T.C.,Mizuno,K.,Konno,Y.,Osada,S.,Ohno,S.and Suzuki,K.: "Purification and characterization of protein Kinase C ε(nPKC ε)from rabbit brain." Biochemistry. 31. 482-490 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 水野 恵子、大野 茂男: "プロテインキナーゼCアイソザイムの同定" 実験医学. 11(3). 163-169 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ohno,S.: "Diversity and specificity of multiple protein kinase C." Progress in Endocrinology,Parthenon Press.,

    • Related Report
      1992 Annual Research Report
  • [Publications] 大野 茂男: "C-キナーゼとシグナル伝達" 腎臓学 Key Notes,東京医学社, 2 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Ohno,Y.Akita,A.Hata,S.Osada,K.Kubo,Y.Konnno,K.Akimoto,K.Mizuno,T.Saido,T.Kuroki and K.Suzuki.: "Strutural and functional diversities of a family of signal transducing protein Kinases,protein Kinase C family;two distinct classes of PKC,conventional cPKC and novel nPKC" Advances in Enzyme Regulation,Pergamon Press. 31. 287-303 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] G.Yu,S.Ahmad,A.Aquino,C.R.Fairchild,J.B.Trepel,S.Ohno,K.Suzuki,T.Tsuruo,K.H.Cowan and R.I.Glazer.: "Transfection with protein Kinase Cα confers increased multidrug resistance to MCFー7 cells expressing PーGlycoprotein." Cancer Communications. 3. 181-189 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.C.Saido,K.Mizuno,Y.Konno,S.Osada,S.Ohno and K.Suzuki.: "Purification and characterization of protein Kinase C ε(nPKCε)from rabbit brain." Biochemistry. 31. 482-490 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Yamaoka,S.Ohno,H.Kawasaki and K.Suzuki.: "Overexpression of A βーGaractoside binding protein causes transformation of BALB3T3 Fibroblast cells." Biochemical and Biophysical Research Communications. 179. 272-279 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Konno,Y.Natsumeda,M.Nagai,Y.Yamaji,S.Ohno,K.Suzuki and G.Weber.: "Expression of human IMP dehydrogenase types I and II in escherichia coli and distribution in human normal lymphocytes and leukemic cell lines." The Journal of Biological Chemistry. 266. 506-509 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Mizuno,K.Kubo,T.C.Saido,Y.Akita,S.Osada,T.Kuroki,S.Ohno and K.Suzuki.: "Structure and propeties of a ubiquitously expressed protein Kinase C,nPKCδ." Eur.J.Biochemistry. 202. 931-940 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Niino,S.Ohno and K.Suzuki.: "Positive and negative regulation of the transcription of the human protein Kinase C β gene." The Journal of Biological Chemistry. 267. (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 水野 恵子,大野 茂男: "バイオシグナル実験法シリ-ズII(蛋白質リン酸化実験法)ープロテインキナ-ゼCアイソザイムの同定" 実験医学. 9(17). 2271-2276 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 水野 恵子,大野 茂男: "プロテインキナ-ゼCの多様性と細胞情報伝達の制御" 最新医学. 46(9). 1877-1883 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大野 茂男,秋田 朗子,羽田 明子,秋本 和憲,水野 恵子,長田 真一,鈴木 紘一: "Protein Kinase C isozymeと細胞機能" 神経と免疫研究. 4. 14-19 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大野 茂男: "がんのバイオサイエンス3(黒木登志夫編)" 東大出版会, 156 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大野 茂男,矢原 一郎,御子柴 克彦,月田 承一郎編: "Annual Review細胞生物学" 中外医学社, 395 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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