| Project/Area Number |
03454206
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
公衆衛生学
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| Research Institution | Toyama Medical & Pharmaceutical University |
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Principal Investigator |
KASUYA Minoru Toyama Med. & Pharm.Univ. Public Health, 医学部, 教授 (50045382)
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| Co-Investigator(Kenkyū-buntansha) |
KATOH T Toyama Med.& Pharm. Univ. Public Health, 医学部, 助手 (80115162)
AOSHIMA K Toyama Med.& Pharm. Univ. Public Health, 医学部, 助手 (20126501)
TERANISHI H Toyama Med.& Pharm. Univ. Public Health, 医学部, 助教授 (40115184)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1992: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1991: ¥4,600,000 (Direct Cost: ¥4,600,000)
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| Keywords | Cadmium / Renal tubular dysfunction / Epidemiology / Cadmium content in rice / beta_2-microglobulin / alpha_1-microglobulin / Maximum allowable limits of cadmium in rice / Itai-itai disease / 尿細管障害 / 産米中カドミウム / α1-マイクログロブリン / α_1ーマイクログロブリン / 骨量 |
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| Research Abstract |
(1) The pH in the morning urine specimens collected from the 129 men and the 145 women ranged from pH 5.00 to 7.57 and from 5.01 to 7.91, respectively. Fifty-three per cent of the 129 urine specimens from men and 38 per cent of the 145 urine specimens from women had a pH value of 6.0 or lower. The mean urinary pH for the men was 6.05, significantly lower than the mean of 6.20 for the women. An obvious pH-related decrease of beta2-microglobulin (beta2-m) concentration in urine was observed at pH level below 6.0. Although urinary alpha1-microglobulin (alpha1-m) was more stable than beta2-m, it was also affected by urine pH below 6.0. Therefore, first-voiding urine in the morning is not a proper specimen to measure low-molecular-weight proteins.
(2) Epidemiological study on renal tubular dysfunction in inhabitants of the cadmium-polluted Jinzu River basin in Toyama prefecture was made in 1991 and 1992. The subjects included 95 men and 112 women aged 45-61 years who have lived in a cadmium-polluted area and a reference group of 26 men and 29 women in the same age range living in a non-polluted area. Mean of urinary alpha1-microglobulin excretion in the inhabitants of a cadmium-polluted area was significantly higher than that in the inhabitants of a reference area. The subjects who have eaten home-grown rice in the cadmium-polluted area had significantly higher excretion of microglobulin than that observed for the reference group. Hypercalciuria was also found in the inhabitants of a cadmium-polluted area. Detailed clinical investigations are needed on bone metabolism for those subjects.
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