| Project/Area Number |
03454208
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
公衆衛生学
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
HOBARA Tatuya Public Health, Professor, 医学部, 教授 (10116501)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Horuo Public Health, Assistant, 医学部, 助手 (00127763)
OGINO Keiki Public Health, Associate Professor, 医学部, 助教授 (70204104)
|
|---|
| Project Period (FY) |
1991 – 1993
|
| Project Status |
Completed (Fiscal Year 1993)
|
| Budget Amount *help |
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥5,500,000 (Direct Cost: ¥5,500,000)
|
|---|
| Keywords | trichloroethylene / trihalometane / trichloroethanol / trichloroacetic acid / ミネラルウォーター / VHCs / トリハロメタン / メネラルウオーター / テトラクロロエチレン / ハロゲン化炭化水素(VHCs) / テトラクロロエチレン(PCE) / ブロモホルム(CHBr_3) / 四塩化炭素(ccl_4) / 1-1-1-TCE(MC) / トリクロロエチレン(TCE) / クロロホルム(CHcl_3) / ジクロロブロモメタン(CHcl_2Br) / 水道水 / ミネラルウォ-タ- |
|---|
| Research Abstract |
In order to simulate the absorption distribution and excretion of trichloroethlene (TRI), as well as the pharmacokinetics study of formation and elimination of TRI metabolites, TRI was inhaled by dogs for one hour at 700 ppm and TRI metabolites (chloral hydrate, trichloroethanol and trichloroacetic acid) were administered to dogs. TRI concentrations in expired air, arterial blood and venous blood were repeatedly measured. Chloral hydrate (CH), trichloroacetic acid (TCA) and trichloroethanol (TCE) concentrations in serum, urine and bile were also measured. Absorption of TRI was 54.6 mg/kg at 700 ppm and absorption ratio was about 40 % during one hour esposure. The cumulative excretion values in expired air one hour after exposure was 21.0mg/kg. The excretion rate of metabolites from urine and bile for total-trichlorocompounds to the absorbed volume of the TRI from immediately after the start of exposure until one hour after the end of exposure was about 1.4%.
Acoording to TRI exposure study and others, pharnacokinetics studies were made. About 18% of avsorbed TRI was metabolized to CH, tce and TCA for one hour after the end of exposure.
|
