| Project/Area Number |
03454218
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
内科学一般
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
MARUMO Fumitaki Tokyo Med. & Dent. Univ., Dept. Med., Professor, 医学部, 教授 (00050443)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIROE M Tokyo Med. & Dent. Univ., Dept. Med., Assistant Professor, 医学部, 講師 (80101872)
HIRATA Y Tokyo Med. & Dent. Univ., Dept. Med., Associate Professor, 医学部, 助教授 (50135787)
|
|---|
| Project Period (FY) |
1991 – 1993
|
| Project Status |
Completed (Fiscal Year 1993)
|
| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1993: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1992: ¥2,500,000 (Direct Cost: ¥2,500,000)
|
|---|
| Keywords | Brain natriuretic peptide / Atrial natriuretic peptide / Congestive heart failure / Myocardial infarction / BNP / ANP / ストレス / 心筋細胞 / 発現調節 / サイトカイン / 脳性Na利尿ペプチド(BNP) / 心房性Na利尿ペプチド(ANP) / 心不全 / プロセシング |
|---|
| Research Abstract |
The objective of the present investigation was to clarify the clinical significance of brain natriuretic peptide (BNP) in various cardiac diseases compared to that of atrial natriuretic peptide (ANP). Plasma BNP levels in normal subjects were 2-4pg/ml, which were one-fifth those of ANP.However, under pathological conditions, such as hypertension, chrome renal failure, congestive heart distress syndrome, plasma BNP levels were remarkably elevated which exceeded those of ANP.Plasma BNP levels showed prognostic marker for cardiac deseases. While plasma ANP was derived from atria, plasma BNP was it is concluded that BNP is exclusively secreted from ventricle in response to acute stress. Which may function as one of the cardiac compensatory mechanisms to reduce both pre-and after load under the pathological states.
|
