| Project/Area Number |
03454219
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | KAGOSHIMA UNIVERSITY |
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Principal Investigator |
OSAME Mitsuhiro Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (10041435)
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| Co-Investigator(Kenkyū-buntansha) |
IZUMO Shuji Kagoshima University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (30143811)
NOMOTO Masahiro Kagoshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50208401)
MARUYAMA Ikuro Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (20082282)
SONODA Shunro Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (40036463)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1991: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Keywords | HAM / TSP / HTLV-I / Retrovirus / HTLV-I associated myelopathy / HTLV-I associated mylopathy / 成人T細胞白血病ウイルス / HTLVーI / HTLVーI脊髄症 / 脊髄症 / HTLVーI関連症候群 / シェグレン症候群 / HTLVーI筋炎 |
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| Research Abstract |
This research provided several important results during these two years of investigation. In Kasari-town, which is a remote island in Kagoshima, we examined 384 inhabitants. Among them, 36(9.4%) had anti-HTLV-I antibodies in the serum. A longitudinal study of carriers will be done in the coming ten years. Lymphocyte separation was performed from 800 patients and family members who were admitted at Kagoshima University hospital. All of these samples were stored in liquid nitrogen.
The clinical features and the laboratory data of 208 patients with HAM were entered in the computer for analysis. The results provided several important information regarding HAM. For instance, HAM may not sometimes have anti-HTLV-I antibodies in cerebrospinal fluid. The associated diseases in patients with HAM were also analyzed and their prevalence were calculated. The pathomechanisms of HTLV-I associated arthropathy, alveolitis, Shjogren syndrome, myositis. IgA nephropathy and pseudohypoparathyroidism were investigated and several important findings could be obtained. Five autopsied cases HAM were studied for neuropathological analysis. The specific importance of CD8lymphocytes was observed. Cytotoxic CD8 cells for the pX region were also found in the blood of patients. More than ten different therapeutic regimens were tried in HAM with very encouraging results.
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