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STUDIES ON NON-ANTIBIOTIC THERAPY FOR INTRACTABLE RESPIRATORY TRACT INFECTIONS

Research Project

Project/Area Number 03454233
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionNAGASAKI UNIVERSITY

Principal Investigator

MATSUMOTO Keizo  INSTITUTE OF TROPICAL MEDICINE,DEPARTMENT OF INTERNAL MEDICINE,PROFESSOR, 熱帯医学研究所, 教授 (40004767)

Co-Investigator(Kenkyū-buntansha) TAO Misao  FACULTY OF MEDICINE,NAGASAKI UNIVERSITY HOSPITAL,ASSISTANT PROFESSOR, 医学部・附属病院, 助手 (80187913)
UTSUNOMIYA Yoshiaki  FACULTY OF MEDICINE,NAGASAKI UNIVERSITY HOSPITAL,ASSISTANT PROFESSOR, 医学部・附属病院, 助手 (40193916)
OISHI Kazunori  INSTITUTE OF TROPICAL MEDICINE,DEPARTMENT OF INTERNAL MEDICINE,ASSISTANT PROFESS, 熱帯医学研究所, 助手 (80160414)
RIKITOMI Naoto  FACULTY OF MEDICINE,NAGASAKI UNIVERSITY HOSPITAL,LECTURER, 医学部・附属病院, 講師 (70175032)
NAGATAKE Tsuyoshi  INSTITUTE OF TROPICAL MEDICINE,DEPARTMENT OF INTERNAL MEDICINE,ASSOCIATE PROFESS, 熱帯医学研究所, 助教授 (30164445)
真崎 宏則  長崎大学, 医学部・附属病院, 助手 (40244058)
高橋 淳  長崎大学, 医学部・附属病院, 講師 (50171468)
隆杉 正和  長崎大学, 医学部附属病院, 助手 (90163203)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥3,800,000 (Direct Cost: ¥3,800,000)
KeywordsIntractable respiratory infections / Nosocomial pneumonia / Non-antibiotic therapy / Disinfecting the pharynx / Immunotherapy / Mechanism of adherence / Inflammatory cytokines / ブランハメラ・カタラーリス / フィンブリエ / メディエーター / レセプター / リポポリサッカライド / 抗鞭毛抗体 / 緑膿菌 / モノクローナル抗体 / 附着 / LPS(エンドトキシン) / 血清感受性 / 抗緑膿菌モノクローナル抗体 / インフルエンザ菌 / 肺炎球菌 / ブランハメラ・カタラ-リス / アタッチメント予防法 / 免疫学的療法 / モノクロ-ナル抗体
Research Abstract

Distribution of diseases in Japan have been changing due to increase of the geriatric population and change in treatment of diseases, such as, ateroid therapy and chemotherapy including anti-cancer chemotherapy. We are facing intractable problems such as nosocomial infection by resistant bacteria. Now-a-days there is rapid development of new antimicrobials though we are unable to control these infections. Therefore we are developing non-antibiotic therapy for these infections. Followings are the results obtained through our studies :
I.Studies on the prevention of respiratory infections :
(1) Patients with repeated respiratory infections had a significant association with the bacterial colonization in the naso-and oropharynx.
(2) We recognized the bactericidal effect of povidone-iodine. Gargling with povidone-iodine remarkably decressed the incidence of respiratory infections by disinfecting the pharynx.
(3) Studies on the mechanism of adherence proved that fimbriae is an important mediator of adherence in B.catarrhalis. We showed evidences that specific sugar is the receptor on pharyngeal cells for the adherence of bacteria.
(4) We studied nosocomial infections by methicillin resistant Staphylococcus aureus (MRSA) in a hospital where this infection were dominant. We demonstrated that prevention of transmission, such as, washing hands of health care personnel, disinfecting rooms and treatment of bed sore decreased significantly the incidence of pneumonia and sepsis by MRSA.
II.Studies on immunotherapy :
(1) We proved that in mouse pneumonia model, efficacy of treatment is enhanced when anti-pseudomonal lipopolysaccharide monoclonal antibody was combined with antibiotic than antibiotic alone.
(2) In the sputum, cytokines such as interleukin 8 has correlation with the course of the disease. Therefore controlling the cytokines might be beneficial for the patients with intravtable respiratory diseases.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] Naoto Rikitomi,et al.: "Mechanism of Adherence of moraxella(Branhamella)catarrhalis." Scandinavian Journal of Infectious Diseases. 23. 559-569 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 松本慶蔵: "総論「耐性菌を作らないための化学療法」" 化学療法の領域. 7. 7-10 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 永武毅,中山隆英: "感染症の予防 1.咽頭殺菌療法" 化学療法の領域. 7. 90-98 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 力富直人,K.Ahmed: "感染症の予防 2.アタッチメント予防(抑制)法" 化学療法の領域. 7. 99-105 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 大石和徳: "化学療法における非抗生剤療法 1.モノクローナル抗体" 化学療法の領域. 7. 114-119 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 田尾操: "化学療法における非抗生剤の治療法 2.モノクローナル抗体と化学療法剤の併用" 化学療法の領域. 7. 120-125 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazunori Oishi,et al.: "Pharmacodynamic and Profective properties of a Murine Lipopolysaccharide-Specific Monoclonal Antibody in Experimental Pseudomonas aeruginosa Pneumonia in Mice." Microbiology and Immunology. 35(12). 1131-1141 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ahmed,et al.: "Ultrastrurctural Study on the Adherence of Branhamella catarrhalis to Oropharyngeal Epithelial Cell." Microbiology and Immunology. 36(6). 563-573 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 田中宏史,他: "呼吸器病原性ブランハメラ・カタラーリスLPSの生化学的分析と呼吸器感染症患者血清中抗LPS抗体の役割" 感染症学雑誌. 66(6). 709-715 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazunori Oishi,et al.: "Efects of the Combination of Lipopolysaccharide-Specific Monoclonal Antibodies and Sparfloxacin against Pseudomonas aeruginosa Pneumonia in Neutropenia mice." Antimicrobial Agents and Chemotherapy. 36(7). 1352-1357 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ahmed,et al.: "Fimbriation,Hemagglutination and Adherence Properties of Fresh Clinical Isolates of Branhamella catarrhalis." Microbiology and Immunology. 36(10). 1009-1017 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazunori Oishi,et al.: "Therapeutic Effects of a Human Antiflagella Monoclonal Antibody in a Neutropenic Murine Model of Pseudomonas aeruginosa pneumonia." Antimicrobial Agents & Chemotherapy. 37(2). 164-170 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 力富直人: "褥瘡感染-とくにMRSAについて" 綜合臨牀. 42(6). 2058-2062 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Pollack,et al.: "Antibacterial and antiendotoxic actions and interactions of lipopolysaccharide antibodies and complement." Bacterial endotoxin. 113-122 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 大石和徳、他: "サイトカインから見た感染症の病理-呼吸器感染症における好中球浸潤と炎症性サイトカインを中心に-" 化学療法の領域. 9(7). 23-29 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 力富直人: "老人病院におけるMRSA対策とその成果-患者の上気道・褥瘡および環境対策の成果-" 化学療法の領域. 9(8). 61-67 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naoto Rikitomi et al: "Mechanism of adherence of Moraxlla (Branhamella) catarrhalis" Scandinavian Journal of Infectious Diseases.23. 559-569 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Keizo Matsumoto: "Introduction "chemotherapy without making resistant strains."" Antibiotics and Chemotherapy. 7. 7-10 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tsuyoshi Nagatake et al.: "Prevention of infectious diseases 1." Disinfecting the pharynx.Antibiotics and Chemotherapy. 7. 90-98 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naoto Rikitomi et al.: "Prevention of infectious diseases 2." Protection of bacterial adherence. Antibiotics and Chemotherapy. 7. 99-105 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazunori Oishi: "Non-antibiotic therapy 1." Monoclonal antibody. Antibiotics and Chemotherapy. 7. 114-119 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Misao Tao: "Non-antibiotic therapy 2." Combination therapy with monoclonal antibody. Antibiotics and Chemotherapy. 7. 120-125 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazunori Oishi, et al.: "Pharmacodynamic and protective properties of a murine lipopolysaccharide-specific monoclonal antibody in experimental Pseudomonas aeruginosa pneumonia in mice." Microbiology and Immunology. 35 (12). 1131-1141 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ahmed, et al.: "Ultrastructural study on the adherence of Branhamella catarrhalis to oropharyngeal epithelial cell." Microbiology and Immunology. 36 (6). 563-573 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirofumi Tanaka et al.: "Biochemical analysis of lipopolysaccharide (LPS) from Branhamella catarrhalis, a respiratory pathogen and function of anti-LPS antibody." Journal of the Japanese Association for Infectious Diseases. 66 (6). 709-715 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazunori Oishi, et al.: "Effects of the combination of lipopolysaccharide-specific monoclonal antibodies and sparfloxacin against Pseudomonas aeruginosa pneumonia in neutropenia mice." Antimicrobial Agents and Chemotherapy. 36 (7). 1352-1357 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Ahmed, et al.: "Fimbriation, hemagglutination and adherence properties of fresh clinical isolates of Branhamella catarrhalis." Microbiology and Immunology. 36 (10). 1009-1017 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazunori Oishi, et al.: "Therapeutic effects of a human antiflagella monoclonal antibody in a neutropenic murine model of Pseudomonas aeruginosa pneumonia." Antimicrobial Agents & Chemotherapy. 37 (2). 164-170 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naoto Rikitomi: "Decubitus ulcer infection-with special reference to MRSA." Sogorinsho. 42 (6). 2058-2062 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Pollack, et al.: "Antibacterial and antiendotoxic actions and interactions of lipopolysaccharide antibodies and complement." Bacterial endotoxin. 113-122 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kazunori Oishi et al.: "A view from cytokine in the pathogenesis of infectious diseases-with special reference to neutrophil infiltration and inflammatory cytokines." Antibiotics and Chemotherapy. 9 (7). 23-29 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naoto Rikitomi: "Control of MRSA infections in a geriatric hospital-results of disinfecting the pharynx and decubitus ulcer of patients, and cleaning the environment." Antibiotics and Chemotherapy. 9 (8). 61-67 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 力富直人: "褥瘡感染 -とくにMRSAについて-" 総合臨床. 42巻. 2058-2062 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 力富直人: "老人病院におけるMRSA対策とその成果" 化学療法の領域. 9巻. 1489-1495 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大石和徳: "サイトカインから見た感染症の病理" 化学療法の領域. 9巻. 1263-1269 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Oishi: "Antibacterial and antiendotoxic actions and interactions of lipopolysaccharide antibodies and complement" Bacterial Endotoxin. 113-122 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] KAZUNORI OISHI: "Terapeutic Effects of a Human Antiflagella Monoclonal Antibody in a Neutropenic Murine Model of Pseudomonas aeruginosa Pneumonia" ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. .Vol.37. 164-170 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kazunori Oishi,Tsuyoshi Nagatake,Keizo Matsumoto et al: "Effects of the Combination of Lipopolysaccharide-Specific Monoclonal Antibodies and Sparfloxacin against Pseudomonas aeruginosa Pneumonia in Neutropenic Mice" ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 36. 1352-1357 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Keizo Matsumoto et al: "Mechanism of Adherence of Moraxella(Branhamella) catarrhalis" Scand J Infect Dis. 23. 559-567 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Keizo Matsumoto et al: "Fimbriation,Hemagglutination and Adherence Properties of Fresh Clinical Isolates of Branhamella catarrhalis" Microbil Immunol. 36. 1009-1017 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 大石 和徳、永武 毅、松本 慶蔵: "呼吸器病原性ブランハメラ・カタラーリスLPSの生化学的分析と呼吸器感染症患者血清中抗LPS抗体の役割" 感染症学会雑誌. 66. 709-715 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tsuyoshi Nagatake,Keizo Matsumoto: "Ultrastructural Study on the Adherence of Branhamella catarrhalis to Oropharyngeal Epithelial Cell" Microbil Immunol. 36. 563-573 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] KAZUNORI OHISHI: "Pharmacodynamic and Protective Properties of a Murine LipopolysaccharideーSpeafic Monoclonal Antibody in Experimental Pseudomonas aeruginosa Pneumonia in Mice" Microbiology and Immunology. 35. 1131-1141 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] NAOTO RIKITOMI: "Mechanism of Adherence of Moraxella(Branhamella)catarrhalis" Scandinavian J.Int.Dis.23. 559-569 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松本 慶藏: "「耐性菌を作らないための化学療法」総論" 化学療法の領域 増刊号. 7. 7-10 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 永武 毅: "感染症の予防 1.咽頭殺菌療法" 化学療法の領域 増刊号. 7. 90-98 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 力富 直人: "感染症の予防 2.アタッチメント予防(抑制)法" 化学療法の領域 増刊号. 7. 99-105 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 大石 和徳: "化学療法における非抗生剤療法 1.モノクロ-ナル抗体" 化学療法の領域 増刊号. 7. 114-119 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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