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Studies on Non-invasive Measurement of Integrative Higher Brain Function and Disorders.

Research Project

Project/Area Number 03454282
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

YONEKURA Y.  Kyoto Univ. Faculty of Med. Assoc. Prof., 医学部, 助教授 (60135572)

Co-Investigator(Kenkyū-buntansha) NAGAMINE T.  Kyoto Univ. Faculty of Med. Assistant, 医学部, 助手 (10231490)
TAMAKI N.  Kyoto Univ. Faculty of Med. Lecturer, 医学部, 講師 (30171888)
MAGATA Y.  Kyoto Univ. Faculty of Med. Assistant, 医学部, 助手 (20209399)
SAJI H.  Kyoto Univ. Faculty of Pharm. Assoc. Prof, 薬学部, 助教授 (40115853)
ITO H.  Kyoto Univ. Faculty of Med. Assoc. Prof., 医学部, 助教授 (40026943)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1992: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1991: ¥5,200,000 (Direct Cost: ¥5,200,000)
KeywordsHigher brain function / Non-invasive measurement / Positron emission tomography / Electroencephalography / Magnetoencephalography
Research Abstract

In order to understand the complicated higher function of the human brain and its disorders in various diseases, it is important to have a multidisciplinary approach from different fields of basic and clinical sciences. Recently introduced new imaging techniques, such as positron emission tomography (PET) and magnetic resonance imaging (MRI) not only provide with valuable information as a clinical diagnostic tool but also serve as an essential method to understand the higher brain function and its deterioration. The aim of this study is to construct an integrative system to understand the higher brain function, combining functional images by means of the radionuclide approach, morphological images, and electrophysiological measurement.
During the past two years, we have made devoted our effort to establish each method and then developed an integrated system to combine these methods. By applying these techniques for various diseases, we have clarified the alteration of cerebral circulation and metabolism as well as electrophysiological changes in cases with impaired brain function. These results also clarified the necessity of single photon emission computed tomography (SPECT) for wide clinical use, and several new radiotracers have been developed for SPECT measurement of regional blood flow, metabolism and neurotransmission process. For the analysis of functional images obtained by PET and SPECT, we have developed a three dimensional image analysis system using a Macintosh based computer system, which enables to display and analyze these functional images superimposed on MRI data in each individual subject. The system permits to identify the physiological response in regional cerebral blood flow by neuronal activation.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Keiichi Kawai: "A strategy for the study of cerebral amino acid transport using iodine-123 labeled amino acid radiopharmaceutical." Journal of Nuclear Medicine. 32. 819-824 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hidenao Fukuyama: "Coronal reconstruction images of glucose metabolism in Alzheimer's disease." Journal of Neurological Science. 106. 128-134 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 石川 正恒: "悪性グリオーマにおけるブドウ糖輸送" CT研究. 13. 247-251 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 米倉 義晴: "ガス状標識化合物を用いて合成した ^<15>O標識ガス吸入法による局所脳機能測定の臨床的有用性の検討" RADIOISOTOPES. 40. 493-500 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kazuta Matsumoto: "Application of the new zinc-62/copper-62 generator:an effective labeling method for ^<62>Cu-PTSM." Nuclear Medicine and Biology. 19. 39-44 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hideo Saji: "Synthesis of (S)-N-[methyl-11C]nicotine and its regional distribution in the mouse brain:a potential tracer for visualization of brain nicotinic receptors by positron emission tomography." Chemical & Pharmaceutical Bulletin. 40. 737-736 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hideo Saji: "Preparation of ^<123>I-labeled 2'-iodospiperone and imaging of D_2 dopamine receptors in human brain using SPECT." Nuclear Medicine and Biology. 19. 734-736 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hiroshi Yamauchi: "Crossed cerebellar hypoperfusion in unilateral major cerebral artery occlusive disorders." Journal of Nuclear Medicine. 33. 1632-1636 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shinya Yamaguchi: "Effect of brovincamine on cerebral circulation and metabolism in internal carotid artery occlusion examined by positron emission tomography." European Neurology. 32. 314-317 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takashi Nagamine: "Current source density mapping of somatosensory evoked responses following median and tibial nerve stimulation." Electroencephalography and Clinical Neurophysiology. 84. 248-256 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yasuhisa Fujibayashi: "^<62>Cu-pyruvaldehyde bis(N^<4+>-methylthiosemicarbazone)(^<62>Cu-PTSM) in the murine brain;a novel radiopharmaceutical for brain positron emission tomography (PET) imaging." Biological & Pharmaceutical Bulletin. 16. 146-149 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshiharu Yonekura: "Functional mapping of flow and back-diffusion rate of N-isopropyl-p-iodoamphetamine in human brain." Journal of Nuclear Medicine. 34. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kawai K, et al: "A strategy for the study of cerebral amino acid transport using iodine-123 labeled amino acid radiopharmaceutical: 3-iodo- alpha-methyl-L-tyrosine." J Nucl Med. 32. 819-824 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fukuyama H, et al: "Coronal reconstruction images of glucose metabolism in Alzheimer's disease." J Neurol Sci. 106. 128-134 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ishikawa M, et al: "Glucose transport in malignant glioma." Prog CT. 13. 128-134 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yonekura Y, et al: "Clinical value of measurement of regional brain function with inhalation of^<15>O labeled gas synthesized with automated labeled gas production system." Radioisotopes. 40. 493-500 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsumoto K, et al: "Application of the new zinc-62/copper-62 generator: an effective labeling method for^<62>Cu-PTSM." Nucl Med Biol. 19. 39-44 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saji H, et al: "Synthesis of(S)-N-[methyl-^<11>C]nicotine and its regional distribution in the mouse brain: a potential tracer for visualization of brain nicotinic receptors by positron emission tomography." Chem Pharm Bull. 40. 737-736 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saji H, et al: "Preparation of^<123>I-labeled 2'-iodospiperone and imaging of D_2 dopamine receptors in human brain using SPECT." Nucl Med Biol. 19. 734-736 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamauchi H, et al: "Crossed cerebellar hypoperfusion in unilateral major cerebral artery occlusive disorders." J Nucl Med. 33. 1632-1636 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamaguchi S, et al: "Effect of brovincamine on cerebral circulation and metabolism in internal carotid artery occlusion examined by positron emission tomography." Eur Neurol. 32. 314-317 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nagamine T, et al: "Current source density mapping of somatosensory evoked responses following median and tibial nerve stimulation." Electroenceph Clin Neurophysiol. 84. 248-256 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujibayashi Y, et al: "^<62>Cu-pyruvaldehyde bis(N^<4+>- methylthiosemicarbazone)(^<62>Cu-PTSM) in the murine brain; a novel radiopharmaceutical for brain positron emission tomography (PET) imaging." Biol Pharm Bull. 16. 146-149 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yonekura Y, et al: "Functional mapping of flow and back-diffusion rate of N-isopropyl-p-iodoamphetamine in human brain." J Nucl Med. 34. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hideo Saji: "Preparation of ^<123>I-labeled 2^1-iodospiperone and imaging of D_2 dopamine receptors in human brain using SPECT." Nuclear Medicine and Biology. 19. 734-736 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hiroshi Yamauchi: "Crossed cerebellar hypoperfusion in unilateral major cerebral artery occlusive disorders." Journal of Nuclear Medicine. 33. 1632-1636 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Shinya Yamaguchi: "Effect of brovincamine on cerebral circulation and metabolism in internal carotid artery occlusion examined by positron emission tomography." European Neurology. 32. 314-317 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takashi Nagamine: "Current source density mapping of somatosensory evoked responses following median and tibial nerve stimulation." Electroencephalography and Clinical Neurophysiology. 84. 248-256 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yasuhisa Fujibayashi: "^<62>Cu-Pyruvaldehyde bis(N^<4+>-methylthiosemicarbazone)(^<62>Cu-PTSM)in the murine brain;a novel radiopharma-ceutical for brain positron emission tomography(PET)imaging." Biological&Pharmaceutical Bulletin. 16. 146-149 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshiharu Yonekura: "Functional mapping of flow and back-diffusion rate of N-isopropyl-p-iodoamphetamine in human brain." Journal of Nuclear Nedicine. 34. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kazuya Matsumoto: "Application of the new zincー62/copperー62 generator:an effective labeling method for ^<62>CuーPTSM." Nuclear Medicine and Biology. 19. 39-44 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hidenao Fukuyama: "Coronal reconstruction images of glucose metabolism in Alzheimer's disease." Jourral of Neurological Sciences. 106. 128-134 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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