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A STUDY OF INTRATUMORAL DISTRIBUTION OF Gd-DTPA ON DYNAMIC MRI

Research Project

Project/Area Number 03454283
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKOBE UNIVERSITY

Principal Investigator

KONO Michio  M.D., Kobe University School of Medicine, Department of Radiology, professor, 医学部, 教授 (60030938)

Co-Investigator(Kenkyū-buntansha) ITOUJI Eiichirou  M.D., Kobe University School of Medicine, Department of Radiology, assistant pro, 医学部・附属病院, 助手 (90243302)
YAMASAKI Katuhito  M.D., Kobe University School of Medicine, Department of Radiology, assistant pro, 医学部, 助手 (50210381)
HIROTA Shozo  M.D., Kobe University School of Medicine, Department of Radiology, lecturer, 医学部・附属病院, 講師 (20181216)
ADACHI Shuji  M.D., Kobe University School of Medecine, Department of Radiology, lecturer, 医学部, 講師 (60159407)
SAKO Masao  M.D., Kobe University School of Medicine, Department of Radiology, associate pro, 医学部・附属病院, 助教授 (60030970)
藤田 善弘  神戸大学, 医学部・附属病院, 助手 (00238594)
藤井 正彦  神戸大学, 医学部, 助手 (00228959)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsdynamic MRI / Gd-DTPA / tumor / lung cancer / hepatocellular carcinoma / rabbit VX2 tumor / 腫瘍内動態 / 家兎VX-2腫瘍 / 血管透過性 / 家兎VXー2腫瘍 / GdーDTPA / 腫瘍伝動態 / 組織内濃度 / 組織内移行 / 悪性腫瘍
Research Abstract

1)The purpose was to clarify the intratumoral distibution of Gd-DTPA on dynamic MRI.
2)Experimental study : a)In a study using rabbit VX2 tumor, alteration of Gd-DTPA concentration in the tumor revealed significantly different from that around tumor and from that of normal tissue. The result meant that dynamic MRI reflected the difference of vascular permeability of various tissues including tumor and that dynamic MRI contributed to the diagnosis of tissue characteristics.
In a study using resected human lung specimen containing cancer, alteration of Gd-DTPA concentration in the tumor revealed pararell to that of signal intensity of the tumor on MRI taken preoperatively, and also revealed low concentration of Gd-DTPA in the necrotic tissue.
3)Clinical Study : In a time-intensity curve analysis of lung cancer on the T1 weighted dynamic study, signal intensity of the lung cancer showed a rapid increase and reached the peak at the time of 3-10 minutes and showed gradual decrease to the time of 30 minutes after injection of contrast medium. Gd-DTPA enhanced MRI was useful in the diagnosis of tumor extent of lung cancer with secondary change, differential diagnosis of tuberculoma, therapeutic effect after conservative therapy, diagnosis of recurrence from radiation pneumonitis. As for diagnosis for hepatocellular carcinoma, over all accuracy of dynamic MRI revealed superior to that of conventional T2 weighted images especially in the diagnosis of therapeutic effect and recurrence.
4)Conclusion : We studied the distribution of Gd-DTPA in and around the tumor on dynamic MRI experimentally and clinically. Dynamic MRI was a very useful modality to diagnose tumor viability. However, tumor stain by Gd-DTPA mainly depends on the vascular permeability. Research of tumor specific contrast media is essential.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] 楠本昌彦: "末梢部肺癌と結核腫の鑑別におけるGd-DTPA造影MRIの有用性" 臨床放射線. 38. 67-74 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 楠本昌彦: "肺癌画像診断の動向:画像による治療効果判定-腫瘍径と壊死化" 画像診断. 13. 427-434 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 足立秀治: "胸部のMRI肺・縦隔" 臨床医. 19. 1378-1382 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 楠本昌彦: "肺の造影MRI" 〓幹部・四肢の造影MRIシリーズ. 3. 1285-1292 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kono M,Kusumoto M,Adachi S: "Thoracic magnetic resonance imaging." Current Opinion in Radiology. 4(5). 62-68 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kono M,Adachi S.Kusumoto M,Sakai E: "Clinical utility of Gd-DTPA-enhanced magnetic resonance imaging in lung cancer." Journal of thoracic Imaging. 8(1). 18-26 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kono M,Adachi S,Yamasaki K,Itouji E,Kusumoto M,Sakai E,Endo M: "Radiology of lung cancer." Radiation Medicine. 11. 110-121 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kono M,Kusumoto M: "Dynamic imaging-thorax" Magnevist monograph (ed.R Felix A Heshiki, NHosten, H Hricak)Blackwell Scientific Publicaions, Oxford.177-181 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] KusumotoM,Kono M.Adachi S,Yamasaki K,Itouji E,Sakai E, Endo M, Nakamura T,Kimura K: "Gd-DTPA enhanced MR imaging for lung nodules : Differentiation of lung cancer and tuberculoma." Investigative Radiology. (in print). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kono M,Adachi S,Kusumoto M,Sakai E,Itouji E,Yamasaki K,Meno S,Endo M: "Lung cancer - including invasion to the mediastinum, thoracic wall, diaphragma -" Japanese Jounal of Clinical Radiology. 36. 1483-1495 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kusumoto M,Sakai E,Yamasaki K,Fujii M,Itouji E,Endo M,Meno S,Adachi S,Kono M,shimizu T: Japanese Jounal of Diagnostic Imaging. 12. 36-44 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kusumoto M: "Clinical study of evaluation of Gd-DTPA enhanced MRI for lung cancer" Nippon Acta Radiologica. 52. 358-371 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kono M,Sugimoto K,Hirota S,Kusumoto M,Yamasaki K,Adachi S,Sako M: "A experimental study of intratumoral distribution of Gd-DTPA on dynamic MRI - Using rabbit VX2 tumor -" Innervision. 7(7). 9-10 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Adachi S,Kusumoto M,Sakai E,Yamasaki K,Itouji E,Endo M,Kono M: "Diagnostic imaging of lung cancer : Recent topics -Expectation for MRI diagnosis" Japanese Jounal of Clinical Imagiology. 9(1). 46-57 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 楠本昌彦: "末梢部肺癌と結核腫の鑑別におけるGd-DTPA造影MRIの有用性" 臨床放射線. 38. 67-74 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 楠本昌彦: "肺癌画像診断の動向:画像による治療効果判定-腫瘍径と壊死化" 画像診断. 13. 427-434 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 足立秀治: "胸部のMRI-肺・縦隔" 臨床医. 19. 1378-1382 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 楠本昌彦: "肺の造影MRI" 躯幹部・四肢の造影MRIシリーズ. 3. 1285-1292 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 河野 通雄: "Gd-DTPAのdynamic MRIによる腫瘍内動態・分布に関する研究ー家兎VX-2腫瘍を用いた実験的研究" INNERVISION. 7(7). 9-10 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 足立 秀治: "MRI診断への期待" 臨床画像. 9(1). 46-57 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Michio Kono,M.D.: "Clinical Utility of Gd-DTPA-Enhanced Magnetic Resonance Imaging in Lung Cancer" Journal of Thoracic Imaging. 8(1). 18-26 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 足立 秀治,河野 通雄,糸氏 英一郎,楠本 昌彦,酒井 英郎,目野 茂宣,遠藤 正浩,山崎 克人,藤井 正彦: "特集ー肺癌:画像診断の進歩 MRI診断" 臨床画像. 7(11). 44-55 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 河野 通雄,足立 秀治,楠本 昌彦,酒井 英郎,糸氏 英一郎,山崎 克人,目野 茂宣,遠藤 正浩: "〔臨時増刊号 胸部のCT・MRI〕肺癌ー縦隔・胸壁・横隔膜への転移進展を含むー" 臨床放射線. 36(11). 1483-1495 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 楠本 昌彦,酒井 英郎,山崎 克人,藤井 正彦,糸氏 英一郎,遠藤 正浩,目野 茂宣,足立 秀治,河野 通雄,清水 雅史: "肺癌におけるDynamic MRIの有用性" 画像診断. 12(1). 36-44 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 河野 通雄,廣田 省三,杉本 幸司,山崎 克人,藤井 正彦,足立 秀治,佐古 正雄: "GdーDTPAのdynamic MRIによる腫瘍内動態・分布に関する研究" INNERVISION.

    • Related Report
      1991 Annual Research Report
  • [Publications] 楠本 昌彦,河野 通雄: "肺癌におけるGdーDTPA enhanced MRIの有用性に関する臨床的研究" 日本医学射線学会雑誌. 52(3). (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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