| Project/Area Number |
03454287
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TORU Michio Professor Tokyo Medical and Dental University and chairman Department of Neuropsychiatry, 医学部, 教授 (20013972)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Akiko Technician ditto, 医学部, 技官 (40210992)
YAMADA Kazuo Resident ditto, 医学部, 医員
ISHIMARU Masahiko Lecturer ditto, 医学部, 助手 (50242219)
KURUMAJI Akeo Lecturer ditto, 医学部, 助手
SHIBUYA Haruo Associate Professor ditto, 医学部, 助教授 (10158959)
南海 昌博 東京医科歯科大学, 医学部, 助手 (20218069)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1991: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Schizophrenia / Dopamine / Glutamic Acid / NMDA receptor / Glycine binding / Chronic schizophrenia / ド-パミン / ド-パミンD2受容体 / クリシン結合部位 / アスパラギン酸 / シグマ受容体 |
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| Research Abstract |
In this research we found a significant increase in NMDA-associated glycine binding site in chronic schizophrenic brains. A significant increase was observed in the 6 cerebral cortices (supramarginal cortex, angular cortex, somesthetic cortex. visual areal, visual areas 2 and 3, and premotor area). As the other two glutamic acid receptors, such as kainic acid and NMDA, the increased values of binding negatively correlate with glutamic acid values. Thus, the increase in glutamic acid receptors may be postsynaptic compensation for glutamatergic hypofunction in the chronic schizophrenic brain. Hypoglutamatergic states in the chronic brain may be induced by hyperdopaminergic states which have existed for long time in the schizophrenic brain. It is demonstrated that dopamine or its agonists inhibit the release ofglutamic acid from the striatal slices. Recent study using microdialysis showed the same results.Our findings suggest that hyperdopaminergic states coexist with hypoglutamatergic states in the chronic schizophrenic brain. New drugs which activate glutamatergicfunction in the brain could be useful to the chronic states of schizophrenia.
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