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Experimental Study on A Hybrid Type Artificial Esophagus Used Autologus Mucosa Cells Intending Neoesophageal Regenenation

Research Project

Project/Area Number 03454320
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SHIMIZU Yasuhiko  Kyoto University, Res. Ctr. Biomed. Engr. Professor, 生体医療工学研究センター, 教授 (00027111)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Tatsuo  Kyoto University, Res. Ctr. Biomed. Engr. Vice Professor, 生体医療工学研究センター, 助教授 (70227908)
IKADA Yoshito  Kyoto University, Res. Ctr. Biomed. Engr. Professor, 生体医療工学研究センター, 教授 (00025909)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1992: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1991: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsArtificial esophagus / Collagen / Long-term study / Smooth muscle / Esophageal gland / Regenerated tissue / ハイブリッド型人工臓器 / 長期成績 / 腺組織 / 組織再生 / コラ-ゲン / シリコ-ン / 自己口腔粘膜
Research Abstract

We have studied a new type of artificial esophagus made from a silicone tube covered with collagen sponge. The intention was that the collagen sponge would be replaced by host tissue, leading to neoesophagus regeneration. In the previous part of this study, in an attempt to shorten the time of neoesophageal epithelization, we injected buccal mucosal cells into the collagen layer of the artificial esophagus at the time of substitution, and we succeeded in inducing neoesophagus formation and epithelization at an early stage. However the stenosis in the chronic stage still remained. We considered that this stenosis was caused mainly by poor regeneration of submucosal tissue, rather than the grand of reepithelization. Therefore we examined the grade of stenosis according to the time when the stent became disloged. In cases where the stents remained in place for more 4 weeks, stenosis did not occur, and consequently oral feeding remained possible without weight loss after surgery. In this sequence we concluded that the occurrence of stenosis after anastomosis depended on the stenting time, and that stenosis did not develop when the part replaced by our artificial esophagus was stented for at least 4 weeks. Microscopically, the muscle tissue and the esophageal glands were identified in the neoesophagus of the long-term survivors. In the view of this results, we are now attempting to replace the longer esophagus with our artificial esophagus to elucidate the mechanism of regeneration of muscle and gland.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] Osamu IKE: "NEOESOPHAGEAL EPITHELIZATION ON AN ARTIFICIAL ESOPHAGUS WITH COLLAGEN LAYER STRUCTURE" Clinical Implant Materials. 9. 621-626 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 池 修: "自己粘膜細胞の播種を併用したコラーゲンを用いた人工食道の研究" 人工臓器. 19. 1169-1172 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tohru Natsume: "Experimental Study of a Hybrid Artificial Esophagus Combined with Autologus Mucosa Cells" ASAIO Transactions. 36. M435-M437 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 清水 慶彦: "コラーゲン・シリコーン複合体による人工食道の開発" 機能材料. 10. 20-23 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 池 修: "自己組織の再生を目的とした人工食道の検討" 日本胸部外科学会総会予稿集. 1919 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 夏目 徹: "再構成線維化コラーゲンと細胞との相互作用" 日本バイオマテリアル学会大会予稿集. 26 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 池 修: "コラーゲン・シリコーン複合体による人工食道の実験的研究" 病態生理. 10. 143-148 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 滝本 行延: "polyethyleneフィルムの腫瘍原性とCollagen被覆による抑制効果" 日本バイオマテリアル学会総会予稿集. 82 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 夏目 徹: "モノマー・オリゴマーコラーゲン上での細胞機能" 日本バイオマテリアル学会大会予稿集. 61 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 夏目 徹: "自己組織を誘導するコラーゲン人工食道の組織学的研究" 日本バイオマテリアル学会大会予稿集. 67 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 夏目 徹: "シンポジウム・吸収性材料の臨床応用コラーゲンの臨床応用" 日本バイオマテリアル学会大会予稿集. 36 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 浜島 博: "食道静脈瘤硬化剤Ethanolamine oleate(EO)の昇圧作用についての検討" 日本内科学会近畿地方会予稿集. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 夏目 徹: "バイオマテリアルとしてのコラーゲン" 生体材料. 10. 335-343 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 清水 慶彦: "外科領域におけるコラーゲンの応用" 繊維学会シンポジウム予稿集. C114-118 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 清水 慶彦: "生体内吸収性材料の臨床応用" 創傷治癒研究会予稿集. 9-16 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu IKE: "Experimental Studies on an Aritificial Esophagus" World Biomaterials Longness Transactions. 189 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 滝本 行延: "コラーゲン・シリコーン人工食道におけるシリコーンステント留置期間と術後狭窄の関係についての検討" 日本胸部外科学会雑誌臨時増刊号. 40. 1522 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yukinobu Takimoto: "Long-Term Follow-Up Study of Experimental Replacement of esophagns with a collagen-sihione composite to" ASAIO Abstracts. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hiroshi Hamashima: "VASOPRESSOR CHANGES BY ENDOSCOPIC INJECTION SCLEROTHERAPY" The World Longresses of Gastroenterolgy. PD1135 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 夏目 徹: "バイオマテリアルとしてのコラーゲン" 繊維学会シンポジウム予稿集. C122-C124 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O. Ike: "NEOESOPHAGEAL EPITHELIZATION ON AN ARTIFICIAL ESOPHAGUS WITH COLLAGEN LAYER STRUCTURE" Clinical Implant Materials. 621-626 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O. Ike: "EXPERIMENTAL STUDIES OF AN ARTIFICIAL ESOPHAGUS USING COLLAGEN WITH SEEING OF CULTURED MUCOSAL CELLS" Jpn. J. of Artif. Organs. 19. 1169-1172 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T. Natsume: "Experimental Study of a hybrid Artificial Esophagus Combined with Autologus Mucosa Cells" SAIO Transactions. 36. 435-437 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] N. Okumura: "Experimental Study on an Artificial Trachea Made from Collagen-grafted Mesh" Jpn. J. Artif. Organs. 20(2). 635-640 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y. Shimizu: "The development of an artificial esophagus using a collagen coated silicone tube" Function and Materials. 10. 20-23 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O. Ike: "Experimental studies on an artificial esophagus using a collagen coated silicone tube" MEDICINA PHILOSOPHICA. 10. 143-148 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T. Natsume: "COLLAGEN AS BIOMATERIALS" J. of Jpn. Soc. for Biomaterials. 10. 335-343 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O. Ike: "Experimental Studies on an Artificial Esophagus" World Biomaterials Congress Transactions. 189 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y. Takimoto: "Long-Term Follow-up Study of Experimental Replacement of Esophagus with a Collagen-Silicone Composite Tube" ASAIO Transactions. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 浜島 博: "食道静脈瘤硬化剤Ethanolamine oleate(ED)の昇圧作用についての検討" 日本内科学会近畿地方会 予稿集. (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 清水 慶彦: "外科領域におけるコラーゲンの応用" 繊維学会シンポジウム 予稿集. C114-118 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 清水 慶彦: "生体内吸収性材料の臨床応用" 創傷治癒研究会 予稿集. 9-16 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 滝本 行延: "コラーゲン・シリコーン人工食道におけるシリコーンステント留置期間と術後狭窄の関係についての検討" 日本胸部外科学会雑誌(臨時増刊号). 40. 1522- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Osamu Ike: "Experimental Studies on an Artifical Esophagus" World Biomaterials Congress.189- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 夏目 徹: "バイオマテリアルとしてのコラーゲン" 繊維学会シンポジウム予稿集. C122-124 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 夏目 徹: "バイオマテリアルとしてのコラーゲン" 生体材料. 10. 335-343 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yukinobu Takimoto: "Long・Term Follow-up Study of Experimental Replacement of esphagus with a collagen-Silicone composite tube" ASAIO Abstracts. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 池 修: "コラーゲン・シリコーン複合体による人工食道の実験的研究" 病態生理. 10. 143-148 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 池 修: "自己組織の再生を目的とした人工食道の検討" 日本胸部外科学会雑誌. 38. 365 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] OSAMU IKE: "Neoesophageal epithelization on an artificial esophagus with collagen layer structure" Advannces in Biomaterials. 9. 621-626 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 池 修: "自己粘膜細胞の播種を併用したコラ-ゲンを用いた人工食道の検討" 人工臓器. 19(3). 1169-1172 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 夏目 徹: "再構成線維化コラ-ゲンと細胞との相互作用" 日本バイオマテリアル学会大会予稿集. 26 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 夏目 徹: "自己組織を誘導するコラ-ゲン人工食道の組織学的研究" 日本バイオマテリアル学会大会予稿集. 67 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 滝本 行延: "Polye the lene フィルムの腫瘍原性とCollagen被覆による抑制効果" 日本バイオマテリアル学会大会予稿集. 82 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 夏目 徹: "コラ-ゲンの臨床応用" 日本バイオマテリアル学会大会予稿集. 36 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 夏目 徹: "モノマ-・オリゴマ-コラ-ゲン上での細胞機能" 日本バイオマテリアル学会大会予稿集. 61 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] TOORU NATSUME: "Experimental Study of a Hybrid Artificial Esophagus Combcned with Autologus Mucosal Cells" ASIO TRANSACTIONS. 36. 435-437 (1990)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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