| Project/Area Number |
03454332
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | SHIGA UNIVERSITY OF MEDICAL SCIENCE |
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Principal Investigator |
MORI Atsumi Shiga University of Medical Science, Faculty of Medicine, Professor, 医学部, 教授 (80026971)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITA Takaaki Shiga University of Medical Science, Faculty of Medicine, Lecturer, 医学部, 助手 (30235882)
WATARIDA Shoji Shiga University of Medical Science, Faculty of Medicine, Lecturer, 医学部, 助手 (90191816)
ONOE Masahiko Shiga University of Medical Science, Faculty of Medicine, Lecturer, 医学部, 助手 (90214197)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1993: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1991: ¥3,800,000 (Direct Cost: ¥3,800,000)
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| Keywords | RETROGRADE CEREBRAL PERFUSION / PROFOUND HYPOTHERMIA / PULSATILE PERFUSION / CEREBRAL METABOLISM / 逆行性脳組織潅流 / 超低体温下体外循環 |
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| Research Abstract |
This investigation was to evaluate the beneficial effect of retrograde cerebral perfusion during ciculatory arrest under condition of profound hypothermia. Adult mongrel dogs were placed on cardiopulmonary bypass and were cooled to a nasopharyngeal temperature of 20ﾟC.At this temperature, hypothermic circulatory arrest and retrograde cerebral perfusion(RCP)were performed for 60 minutes. Retrograde cerebral perfusion was performed via the bilateral maxillary veins, and retrograde flow rate was regulated to maintain a mean perfusion pressure of 10,20,30mmHg in the external jugular vein respectively. We also investigated the effects on cerebral metabolism of clamping blood flow through the IVC cannula during RCP and also investigated the effects of pulsatile flow on retrograde cerebral perfusion. Results from these investigation suggest that hypothermia of the central nervous system, the supply of oxygen, the excretion of metabolites, aerobic metabolism, and the cerebral A Tp level were maintained by RCP.A perfusion pressure of 20mmHg was appropriate for RCP and clamping of the venous blood flow through the IVC cannula during RCP is a more protective procedure for cerebral tissue during RCP.And retrograde cerebral perfusion with pulsatile flow has the possibility to control brain edema as compared with non-pulsatile flow.
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