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Basic and clinical studies for the targeting therapy by using the morphometrical analysis in malignant brain tumors.

Research Project

Project/Area Number 03454342
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionUniversity of Tsukuba, Institution of Clinical Medicine

Principal Investigator

YOSHII Yoshihiko  Clin. Med. Neurosurg. Associat. Prof., 臨床医学系, 助教授 (50110507)

Co-Investigator(Kenkyū-buntansha) HYODO A  Clin. Med. Neurosurg. Assistant. Prof., 臨床医学系, 講師 (40167606)
ISHIKAWA Y  Clin. Med. Rad. Associat. Prof., 臨床医学系, 助教授 (10026932)
HAYAKAWA Y  Basic. Med. Rad. Assistant. Prof., 基礎医学系, 講師 (90101740)
MARUHASHI A  Basic. Med. Rad. Associat. Prof., 基礎医学系, 助教授 (30114135)
TSUJII H  Clin. Med. Rad. Prof., 臨床医学系, 教授 (50088853)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsMalignant Brain Tumor / Targeting Therapy / Morphometry / Antitumor Effect / Lntraartenal Therapy / Proton Beam / Heterogeneity / In vivo Diagnosis / ターゲティング / DNA量 / GFAP / 正常脳障害 / 超選択的動注療法
Research Abstract

Improved modern neuroimaging techniques and rigid immobilization systems alow confirmation of the target position relative to the proton beam at each treatment, treatment planning based on beam trajectory, dose at each anatomical point, bolus based on accurate assessment of density along each pixel, etc. Proton therapy in our institute showed that the patient could tolerate radiation doses 15-20% higher than those of conventional radiation therapy used. However, it was suggested that the doses needed 140-160 TDF and the tumor volume was less than 10 ml to cure the patients with malignant brain tumor. Therefore, proton beam will be a main instrument of the morphometric targeting therapy for the brain tumors. Neuroimaging is very helpful in estimating clinically the overall extent of the tumor and the peripheral margin. Gd-DTPA MRI can be used effectively in the diagnosis of tumor viability and malignancy after treatment. Furthermore, ^<201>Tl-SPECT appears to be effective for determination of the malignant viability of tumors. In the effectiveness of superselective 1 A chemotherapy of malignant tumors, the antitumor drug was transported into the tumor at an average rate of 6.3% of the total dose injected intra arterially. In calculating the ratio of the delivered ACNU dose to the tumor volume, ACNU of the average 320 mug/ml might be needed as the effective treatment. From DNA content analysis, it is suggested that the malignant brain tumors have different bilogical heterogeneity and its analysis requires further study for the morphometric targeting therapy.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Yoshii Y: "Normal brain damage after radiotherapy of brain tumors" Clinical Oncology. 3. 278-282 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 兵頭 明夫: "悪性脳腫瘍に対する超選択的動注化学療法の有用性の検討" 日本脳神経血管内手術法研究会講演集. 5. 255-261 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii Y: "Morphometrical analysis of GFAP positive cell in human astrocytomas" Neuro Med Chir. 32. 554-558 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii Y: "Malignancy and viability of intraparenchymal brain tumors" Acta Neurochirurgica. 117. 187-194 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii Y: "The robe of 201 Tl-SPET in the investigation and characterization of brain tumor in man and its response to treat meut" EJNM. 20. 39-45 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii Y: "Proton radiation therapy for clivus chordoma" Neuro Med Chir. 33. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉井 與志彦: "Gliomaと放射線治療" にゅーろん社, 164 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉井 與志彦: "がん治療Q&A(幼児脳腫瘍)" 六法出版社, 121-124 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii,Y et al: "Normal brain damage after radiotherapy of brain tumors" Clinical Oncology. 3. 278-282 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hyodo,A et al: "Superselective intraarterial chemotherapy of malignant brain tumor" Proceedings of Japanese Intravascular Neurosurgery.5. 255-261 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii,Y et al: "Morphometrical analysis of GFAP positive cell in human astrocytomas" Neuro Med Chir. 32. 554-558 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii,Y et al: "Malignancy and viability of intraparenchymal brain tumors" Acta Neurochirurgica. 117. 187-194 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii,Y et al: "The role of ^<201>Tl-SPET in the investigation and characterization of brain tumor in man and its response to treatment" E J N M. 20. 39-45 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshii,Y et al: "Proton radiation therapy for clivus chordoma" Neuro Med Chir. 33. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉井 與志彦: "悪性グリオーマに対する放射線治療の将来的展望" Jpn J Neurosurg. 1. 129-135 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshii Y: "Morphometrical analysis of GFAP positive cell in human astrocytomas" Neuro.Med Chir. 32. 554-558 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshii Y: "Malignancy and viability of intraparenchymal brain tumors" Acta Neurochirurgica. 117. 187-194 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 兵頭 明夫: "Evalによる塞栓術のみで血管造影上完全消失した左前頭葉AVM" 日本脳神経血管内手術研究会講演集. 6. 105-110 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshii Y: "The role of 201 Tl-SPET in the investigation and characterization of brain tumor in man and its response to treatmury" EJNM. 20. 39-45 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshii Y: "Proton radiation therapy for clivus chordoma" Neuro Med Chir. 33. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉井 與志彦: "Gliomaと放射線治療" にゅーろん社, 164 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉井 與志彦: "がん診療Q&A(幼児脳腫瘍)" 六法出版社, 121-124 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshii Y: "Normal brain damage after radiotherapy of brain tumors" Clinical Oncology. 3. 278-282 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takano S: "WeibelーPalade bodies as marker for endothelial proliferative potential of human ghoma capillaries" Biological Aspects of Brain Tumors. 1. 139-145 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 兵頭 明夫: "悪性脳腫瘍に対する超選択的動注化学療法の有用性の検討" 日本脳神経血管内手術法研究会講演集. 5. 255-261 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yoshii Y: "Diagnostic feasibility of thalliam ー201 SPECT in the malignant viability of human brain tumors before and after treatment" Neurosurgery. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yoshii Y: "Proton radiation theragy for clivus chordoma" Acta Neurochirurgica. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 吉井 與志彦: "Gliomaと放射線治療" にゆうろん社, 250 (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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