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EFFECTS OF VASOACTIVE AGENTS ON THE REGIONAL BLOOD FLOW AND THE PERMEABILITY IN MALIGNANT BRAIN TUMORS

Research Project

Project/Area Number 03454349
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

FUKUI Masashi  FACULTY OF MEDICINE, DEPARTMENT OF NEUROSURGERY, PROFESSOR, 医学部, 教授 (10038713)

Co-Investigator(Kenkyū-buntansha) IKEZAKI Kiyonobu  FACULTY OF MEDICINE, DEPARTMENT OF NEUROSURGERY, RESEARCH ASSOCIATE, 医学部, 助手 (10145360)
町 多賀雄  九州大学, 医学部, 助手 (60199718)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1993: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1991: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsmalignant glioma / vasoactive agents / regional blood flow / tumor vessels / 脳腫瘍 / 化学療法 / 血管作動性物質 / 脳血流 / 血液脳関門 / 局所脳血流
Research Abstract

The research project was aimed to study effects of vasoactive agents on the regional cerebral blood flow (rCBF) and the permeability in malignant brain tumors. We studied the effect of the intracarotid administration of various vasoactive agents on the rCBF in brain tumors by hydrogen clearance method using a rat glioma model. The brain tumor vessels are structually and biochemically different from the normal brain vessels, and show an altered response to vasoactive agents, such as histamine, adenosine, ATP, prostacycline (PGI_2), and calcium antagonists. In our experiment, these agents have elevated the rCBF in the brain tumor significantly without affecting the systemic vital signs and the rCBF in the ipsilateral normal brain tissue. The tumor selective percent increase of the rCBF ranged from 30 to 100 % with these agents. Although the mechanism of altered response of the rCBF in the brain tumor vessels should be further investigated, these vasoactive agents are considered to have the potential to be utilized to selectively increase drug deliverry to malignant glioma in the brain.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Nomura T,Ikezaki K,Natori Y,Fukui M: "Altered response to histamine in brain tumor vessels:The selective increse of regional cerebral bolld flow in transplanted rat brain tumor." J Neurosurg. 79. 722-728 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nomura T,Ikezaki K,Matsukado K,Fukui M: "Effects of prostacyclin analogue ilopost on the regional cerebral blood flow in transplanted rat brain tumor." Neurol Res. 15. 401-404 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikezaki K,Nomura T,Takahashi M,et al: "MRI Contrast Enhancement by Mn-TPPS in Experimental Rat Brain Tumor with Peripheral Benzodiaxepine Receptors." J Neurosurg. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nomura T, Ikezaki K, Natori Y, Fukui M: "Altered response to histamine in brain tumor vessels : The selective increase of regional cerebral bolld flow in transplanted rat brain tumor" J Neuronsurg. 79. 722-728 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nomura T, Ikezaki K, Matsukado K, Fukui M: "Effects of prostacyclin analogue ilopost on the regional cerebral blood flow in transplanted rat brain tumor" Neurol Res. 15. 401-404 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ikezaki K, Nomura T, Takahashi M, et al: "MRI Contrast Enhancement by Mn-TPPS in Experimental Rat Brain Tumor with Peripheral Benzodiaxpine Receptors" J Neuronsurg. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nomura T,Ikezaki K,Natori Y,Fukui M: "A1tered response to histamine in brain tumor vessels:The selectiveincrese of regional cerebral bolld flow in transplanted rat brain tumor." J Neurosurg. 79. 722-728 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nomura T,Ikezaki K,Matsukado K,Fukui M: "Effects of prostacylin analogueilopost on the regional cerebral bloodflow in transplanted rat brain tumor." Neurol Res. 15. 401-404 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ikezaki K,Nomura T,Takahashi M,et al: "MRI Contrast Enhancement by Mn-TPPS in Experimental Rat Brain Tumor with Peripheral Benzodiaxepine Receptors." J Neurosurg. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] 野村 智二郎: "悪性グリオ-マにおける選択的腫瘍血流増加の試みーATPおよびアデノシンの作用機序ー" Therapeutic Research. 13. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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