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A Study on the pathogenesis and mechanism of occurence of geriatric fractures.

Research Project

Project/Area Number 03454364
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionTottori University

Principal Investigator

YAMAMOTO Kichizo  Faculty of Med., Tottori University Prof., 医学部, 教授 (00032326)

Co-Investigator(Kenkyū-buntansha) HAGINO Hiroshi  Faculty of Med., Tottori University lecturer, 医学部・附属病院, 講師 (80208412)
KISHIMOTO Hideaki  Faculty of Med., Tottori University lecturer, 医学部, 講師 (00177817)
TESHIMA Ryota  Faculty of Med., Tottori University Associ.Prof., 医学部, 助教授 (50144671)
倉信 耕爾  鳥取大学, 医学部, 助手 (60215043)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥3,800,000 (Direct Cost: ¥3,800,000)
Keywordsosteoporosis / femoral neck fracture / Histomorphometry / Non-invasive bone mineral measurement / scanning electron microscopy / 大腿骨頸部骨折 / 骨折発生頻度 / 生検腸骨 / 骨形態計測 / 腸骨バイオプシー標本 / 腸骨形態計測
Research Abstract

The result of this project consists of three part.
1) Non-invasive bone mineral measurements
The results of bone mineral measurements the spine by DXA was published in the title of "measurements of bone mineral density of lumbar vertebrae in the lateral projection by dual-energy X-ray absorptiometry-comparison with anteroposterior spinal and radial bone mineral measurements-" in J.Jpn. Orthop.Assoc., vol.67 : 49-57,1993. And the results of bone mineral measurements of os calcis was published in the J.Jpn.Orthop.Associ.vol.68 : 1044-1055,1994. under the title of "Bone mineral measurement of the calcaneus by single X-ray absoptiometry" The fracture threshold, defined as the 90% for calcaneus BMC in a women with a vertebral fracture was 313mg/cm^2 and 70.2% of the peak bone mass in the calcaneus.
2) Scanning electron microscopic study of iliac bone biopsy
The functional state of iliac cancellous bone in the postmenopausal women was investigated by SEM and revealed high resorbing activity in the early stage of postmenopause, which was published in Acta Anat. Nipponica vol.68 : 305-315,1993.
3) Histomorphometric Analysis of femoral neck specimen and iliac bone biopsy
To evaluate the bone mass and quality of the femoral neck spcimen and the histomorphometric analysis was performed, which exhibited an increased resorption cavity and intracortical porosity in the cortex as well as endocortical envelop. The bone volume in the femoral neck also significantly lower. However parameters of the iliac bone were not correlated with those of the femoral neck.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 片桐浩史: "単一エネルギーX線吸収法による踵骨の骨量動態に関する研究" 日本整形外科学会雑誌. 68. 1044-1055 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 西原彰彦: "大腿骨頚部間側骨折患者の骨組織形態計測" 日本整形外科学会雑誌. 69(未定). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] H.Katagiri: "Bone Mineral Measurement of the Calcaneus by Single X-ray Absorptiometry" Nippon Seikei-Geka Gakkai Zasshi. 68. 1044-1055 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Nishihara: "Femoral Neck and Iliac Bone Histomorphometry in Femoral Neck Fracture" Nippon Seikei-Geka Gakkai Zasshi. 69 (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hideaki Kishimoto: "The effect of iprifravone on bone mass of osteoporotic women." Journal of Bone and Mineral Metabolism. 11(sup1). S15-S19 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山本吉蔵: "骨粗鬆症の病態生理" 総合臨床. 42. 442-450 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山本吉蔵: "骨粗鬆症の概念と定義" 医学のあゆみ. 165. 499-501 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 豊島良太: "リウマチにおける骨粗鬆症" Clinical Calcium. 3. 1005-1011 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 片桐浩史: "OsteoAnalyzerを用いた男性の踵骨骨塩定量" 整形外科と災害外科. 42(1). 357-359 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山本吉蔵: "骨粗鬆症・腰痛" 臨床と研究. 70. 3787-3795 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 山本吉蔵: "オステオポローシス診断と治療" ライフサイエンス出版, 502 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 岡野 徹: "大腿骨頸部骨折患者の腸骨骨形態計測所見" 日本骨形態計測学会雑誌. 2. 119-123 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡野 徹: "腸骨骨形態計測値と橈骨、腰椎、大腿骨近位部骨塩量との比較" 日本骨形態計測学会雑誌. 2. 251-225 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Yamamoto: "Risk factors for hip fracture in elderly Japanese women in in Tottori Prefecture,Japan" Osteoporosis International. 3(Sup1). S48-50 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Takita: "Fine structure of remodeling sites on iliac cancellous bone in senile osteoporosis:A study scanning electron microscopy using an improved organic specimen preparation method" Cells&Materials. 2. 135-142 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 賀川 武: "DEXA法による側面方向腰椎椎体部骨量測定" 日本骨形態計測学会雑誌. 2. 1-4 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 永島 英樹: "DEXA法による卵巣摘出ラットの骨塩量の検討" 日本骨形態計測学会雑誌. 2. 81-84 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山本 吉藏(分担執筆): "新老年学" 東京大学出版会, 1248 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山本 吉藏: "骨粗鬆症ー最新整形外科薬物療法マニュアルー" Orthopaedies. 35. 75-85 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Yamamoto,H.Hagino,T.Nakamura: "Incidence and risk factors of the hip fractures in Japanese elderly women" Journal of Bone and Mineral Metabolism. 9(2). 168-170 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Hagino,K.Yamamoto,T.Nakamura,T.Nose and H.Oshiro: "Epidemiology of osteoporotic limb fractures in Tottori Prifecture JapanーA three years surveyー" Journal of Bone and Mineral Metabolism. 9Sup. 25-28 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山本 吉藏: "骨粗鬆症に関連した四肢骨折" 外傷研究会会誌. 8. 123-130 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山本 吉藏,岸本 英彰,萩野 浩,賀川 武: "オステオポロ-シスー診断と治療ー診断3シングルフォトン吸収法" ライフサイエンス, (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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