• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Intravenous anesthetics and epinephrine-induced arrhythmias.

Research Project

Project/Area Number 03454375
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionOsaka University

Principal Investigator

YOSHIYA Ikuto  Osaka University Medical School, Professor, 医学部, 教授 (80028505)

Co-Investigator(Kenkyū-buntansha) 澄川 耕二  大阪大学, 医学部, 助教授 (60028660)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsIntravenous anesthetic / Epinephrine / Arrhythmia / プロポフォ-ル
Research Abstract

1. It is well known that halothane and other hydrocarbon anesthetics enhance the epinephrine-induced arrhythmias. Regarding to intravenous anesthetics, thiopental has been reported to enhance the epinephrine-induced arrhythmias to a greater extent than did halothane. However, the effect of other intravenous anesthetics on epinephrine-induced arrhythmias has not been well discussed. Our study was designed to clarify the effect of propofol and etomidate on epinephrine-induced arrhythmias in dogs. The result is that, we clarified that propofol enhanced epinephrine-induced arrhythmias whereas etomidate did not have significant effect on epinephrine-induced arrhythmias. In addition, we determined that the action of propofol was dose-dependent in the presence of a background of etomidate. (Anesthesiology, 1991)
2. Thiopental has been reported to sensitize the heart to the arrhythmogenic action of epinephrine, but the adrenoceptor mechanism involved in the arrhythmogenicity of thiopental remains unknown. We investigated comparative roles of alphal and beta adrenoceptors in myocardial sensitization by thiopental in dogs, and demonstrated that both alphal and beta adrenoceptor activities are important for myocardial sensitization by thiopental to the arrhythmogenic action of epinephrine.
3. In order to extent our previous work on adrenoceptor mechanism of epinephrine-induced arrhythmias, we designed an experimental model to clarify the role of betal and beta2 adrenoceptor using halothane-anesthetized dogs. (Can J Anaesth, 1992) In our next work, we intend to elucidate the role of subtypes of beta adrenoceptor in the genesis of arrhythmias during thiopental anesthesia using this experimental model.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Takahiko Kamibayashi: "Enhancement by propofol of epinephrine-induced arrhythmias in dogs." Anesthesiology. 75. 1035-1040 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yukio Hayashi: "Selective betal and beta2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs." Canadian Journal of Anaesthesia. 39. 873-876 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahiko Kamibayashi: "Enhancement by propofol of epinephrine-induced arrhythmias in dogs." Anesthesiology. 75. 1035-1040 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yukio Hayashi: "Selective beta1 and beta2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anesthetized dogs." Canadian Journal of Anesthesia. 39. 873-876 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahiko Kamibayashi: "Enhancement by propofol of epinephrine-induced arrhytmias in dogs." Anesthesiology. 75. 1035-1040 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yukio Hayashi: "Selective beta1 and beta2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs." Canadian Journal of Anaesthesia. 39. 873-876 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takahiko Kamibayashi: "Enhancement by propofol of Epinephrineーinduced Arrhythmias in Dogs" ANESTHESIOLOGY. 75. 1035-1040 (1991)

    • Related Report
      1991 Annual Research Report

URL: 

Published: 1991-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi