| Project/Area Number |
03454398
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKANO Hitoo Kyushu Univ., Faculty of Med., Dept. of GYN/OB, Professor, 医学部, 教授 (40038766)
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| Co-Investigator(Kenkyū-buntansha) |
SATOHO Shoji Kyushu Univ., Faculty of Med., Dept. of GYN/OB, Assistant Professor, 医学部, 講師 (00225947)
MAEDA Hirotaka Kyushu Univ., School of Health Science, Assodiate Professor, 医療技術短期大学部, 助教授 (20199631)
KOYANAGI Takashi Kyushu Univ., Faculty of Med., Dept. of GYN/OB, Assodiate Professor, 医学部, 助教授 (30136452)
堀本 直幹 九州大学, 医学部, 助手 (40243927)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Human fetus / Ontogenesis / REM sleep / Non-REM sleep / Waking states / Pupillary change / Fetal behavior / Brain impairment / スクリーニングシステム / 出生前診断 / 脳性麻痺 / 超音波電子スキャン / 胎児心拍数陣痛計 / 眼球運動期 / 非眼球運動期 / ウルトラディアン・リズム / 睡眠 / 中枢神経機能異常 / 散瞳 / 縮瞳 / 最小二乗メディアン回帰分析 / 妊娠末期 |
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| Research Abstract |
1) Fetal pupillary deameters were statistically differ-entiated into two groups : 9.7% for dilated pupil and 90.3% for constricted pupil (1.7mm). The percentage of dilated pupil during the eye movement (EM) period (14.3%) was significantly greater than that during no eye movement (NEM) period (2.3%), thereby indicating a close relation between pupillary dilatation and eye movement periods in the human term fetus.
2) From an analysis of time lag between the onset of the EM period and the first micturition thereafter, 72% of all micturitions occurred within 8 min, after the onset of the EM perod in the fetuses at 37 weeks on-wards. This indicates a temporal relationship between the onset of the EM period and the first micturition thereafter.
3) Two statistically critical points for the duration of the EM period were noted at 29-30 and 37-38 weeks' gestation, whereas for the duration of the NEM period, 2 critical points were again found at 31-32 and 37-38 weeks' gestation. These findings su
… More
ggest that two separate mechanisms exist, one for maintaining the duration of the EM period and another for maintaining the duration of the NEM period. Both switching and maintaining mechanisms respinsible for ultradian thythm of EM and NEM periods have matured at term.
4) We examined whether fetal behavioral patterns could be usued to localize sites of brain damage antenatally. Decreased fetal mobement, persistent non-reactive fetal heart rate (FHR) pattern, and/or central nervous system malformation were usued as indicators of possible neuro-logical impairment. 10 fetuses with the above mentioned criteria underwent further ultrasound examination ob-seuving movement of the extremities, breathing, eye and mouth and active/quiet FHR patterns. 8 of these ten fetuses were found, on postnatal examination, to have a brain impairment. the fetuses having potential inutero brain impairment were grouped into four : cases with (1) lesion sites at, or caudal to, the pons-medulla which were specifically identified by fetal behavior, (2) diffuse lesions in the brain which, although resulting in abnormal behavior, could not be localized by this behabior, (3) lesions localized in the cerebral hemi-sphere (s) but no abnormal behavior, and (4) temporally abnormal behavior in utero, finally changing over to a normal pattern with no neonatal neurologic abnormality. A screening system for the antenatal assessment of brain impairment is thus proposed. Less
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