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Study on the relationship between morphological and functional changes in eight nerve lesion.

Research Project

Project/Area Number 03454404
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KOMATSUZAKI Atsushi  Tokyo Medical and Dental University, Department of Otorhinolaryngology, Professor, 医学部, 教授 (50010195)

Co-Investigator(Kenkyū-buntansha) TANAKA Hidekazu  Tokyo Medical and Dental University, Assistant, 医学部, 助手 (50163556)
HENTONA Hitoshi  Tokyo Medical and Dental University, Assistant, 医学部, 助手 (50199452)
横山 和則  東京医科歯科大学, 医学部, 助手
村岡 秀樹  東京医科歯科大学, 医学部, 助手 (40219879)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1991: ¥4,500,000 (Direct Cost: ¥4,500,000)
Keywordseight nerve / acoustic neurinoma / vestibular endorgan / internal auditory canal / calcium carbonate / 骨硬化度 / 炭酸カルシウム / 聴神経腫瘍起源神経 / 聴力保存 / 内耳道骨硬度 / 前庭感覚細胞 / 超微細形態 / 前庭感覚上皮 / 骨量ファントム / 温度眼振 / 前庭器官 / 誘発電位
Research Abstract

Eight nerve lesions in the internal auditory meatus especially in cases of acoustic tumor were studied.
The results obtained were as follows.
1. Morphological changes were studied using electronmicroscope and no special pathological changes were obtained on the vestibular endorgan epithelia even though there were marked functional changes by caloric stimulations.
2. There were no special relationship between the pathology of the vestibular endorgan and the nerve of origin of tumor.
3. In order to investigate that the internal auditory canal is enlarged usually at the porus part than the lateral part in cases of acoustic tumor, content of calcium carbonate was measured by quantitative CT for determination of bone mineral density.
The highest mean value was found in the fundus posterior whereas the lowest in the porus anterior, and there was a significant difference between the value of the fundus and porus.
These results suggest that one of the factors to enlarge on the internal auditory canal especially at the porus.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Ichimura K,Komatsuzaki A et al: "Oncogene Expression in Acoustic Neurinomas." Biological Aspects of Brain Tumors. 337-342 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Watanabe K,Komatsuzaki A: "Membranous cytoplasmic bodies in the lateral wall of the cat cochlea." Ann Otol Rhinol Laryngol. 101(4). 355-359 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okamoto A,Hasegawa M,Komatsuzaki A et al: "Effects of Frequency and Intensity of Sound on cochlea Beood Flow." Acta Otolayngol(Stockh). 112. 59-64 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Komatsuzaki A: "Vertigo." Asian Medical Journal. 36(6). 307-310 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Morita I,Komatsuzaki A et al: "Vestibular Sensory Epithelia in Patients with Acoustic Neurinoma." Acta Otolaryngol(Stockh). 114. 11-17 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 小松崎 篤: "耳鼻咽喉科・頭頚部外科MOOK" 金原出版, 193 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ichimura K, Komatsuzaki A et al: "Oncogene Expression in Acoustic Neurinomas." Biological Aspects of Brain Tumors. 337-342 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Watanabe K, Komatsuzaki A: "Membranous cytoplasmic bodies in the lateral wall of the cat cochlea." Ann Otol Rhinol Laryngol. 101. 355-359 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okamoto A, Hasegawa M, Komatsuzaki A et al: "Effects of Frequency and Intensity of Sound on cochlea Beood Flow." Acta Otolayngol(Stockh). 112. 59-64 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Komatsuzaki A: "VERTIGO" Asian Medical Journal. 36. 307-310 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Morita I, Komatsuzaki A et al: "Vestibular Sensory Epithelia in Patients with Acoustic Neurinoma." Acta Otolaryngol(Stockh). 114. 11-17 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 佐藤 玲子: "小脳腫瘍症例の神経耳科学的考察" Equibrium Res. 52. 153-164 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 辺土名 仁: "骨量ファントムを用いた内耳道壁の骨塩量の測定" 日本耳鼻咽喉科学会会報. 96. 609-616 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 内藤 永恵: "経過中に両側同時発症の突発難聴を呈した多発性神経鞘腫症の1例" 耳鼻咽喉科展望. 36. 607-613 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 角田 玲子: "外耳道温度と温度眼振検査の検討" 日本耳鼻咽喉科学会会報. 96. 1933-1939 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小松崎 篤: "疾患の病態・治療「聴神経腫瘍」" 日本耳鼻咽喉科学会会報. 96. 1986-1989 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ichiro Morita: "Vestibular Sensory Epithelia in Patients with Acoustic Neurinoma." Acta Otolaryngol(Stockh). 114. 11-17 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小松崎 篤: "耳鼻咽喉科・頭頚部外科MOOK" 金原出版, 193 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Ichimura: "Oncogene Expression in Acoustic Neurinomos." Biological Aspects of Brain Tumors.337-342 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡本 文里: "血圧変動と内耳血流動態" 耳鼻と臨床. 37. 1244-1248 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小松崎 篤: "目で見る耳鼻咽喉科臨床検査ー注視眼振および頭位眼振の検査ー" JOHNS. 7. 1493-1498 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 奥野 秀次: "手術により、偶然みとめられた後半規管の限局性線維化および骨化病変" Otology Japan. 2. 279-283 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 辺土名 仁: "聴神経腫瘍における水平、垂直方向の内耳道拡大の相異について" 日本耳鼻咽喉科学会会報. 95. 1198-1205 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 奥野 秀次: "骨導蝸電図での聴神経複合活動電位の同側および対側刺激による差異" Audiology Japan. 35. 690-694 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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