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Research on pathogenesis of Vogt-Koynagi-Harada disease

Research Project

Project/Area Number 03454415
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

INOMATA Hajime  KYUSHU UNIVERSITY FAC.OF MED.Professor, 医学部, 教授 (30038674)

Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1993: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1991: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsVOGT-KOYANAGI-HARADA DISEASE / HLA-DR ANTIGEN / MELANOCYTE / INTERPHOTORECEPTOR MATRIX BINDING PROTEIN / INTERCELLULAR ADHESION MOLECULE / INTERAOCULAR-NEOVASCULAIZATION / ぶどう膜炎 / ベーチェット病 / 血管新生黄班症 / クラス2抗原 / 免疫組織化学 / HLA-DR抗原 / 角膜後面沈着物 / フォ-クト・小柳・原田病 / 脳波 / 皮膚白斑 / 夕焼け状眼底 / 肉芽腫性炎症
Research Abstract

The research was purposed to clarify pathogenesis and mechanism of ocular and extraocular manifestations of Vogt-Koyanagi-Harada disease so that it will be able to contribute for establishment of the treatment and prophylaxis of the disease.
1)Research in 1991
We studied histopathology of the autopsy eyes with Vogt-Koyanagi-Harada disease using technique of immunohistochemistry. We found lymphocytic infiltration in the choroid even at the stage of sun-set glow appearance and HLA-DR antigen expression on choroidal melanocytes which might be a target cell of the inflammation. An experimental animal model was successfully produced in rat eyes after injection of a fragment of peptide from interphotoreceptor matrix binding protein(IRBP) in the foot pad.
2)Research in 1992
We examined immunohistochemically vitiligo in the skin with Vogt-Koyanagi-Harada disease and found that melanocyte in the dermis was a target cell in the inflammation and HLA-DR antigen expression in the melanocytes. Intercellular adhesion molecule-1(ICAM-1) was found to be expressed in the posterior surface on the corneal endothelium in experimentally induced uveitis after injection of peptide of IRBP.
3)Research in 1993
Choroidal neovascularization occurred in the rat eyes after repeated injection of peptide of IRBP into the foot pad. The choroidal neovascularization is one of clinical manifestations of Vogt-Koyanagi-Harada diseasse. Histopathology of 25 eyes with Behcet's disease found that choroidal neovascularization occurred from area of ora serrata. We reviewed clinical and pathological features of Vogt-Koyanagi-Harada disease. The munusript was submitted for publication in Survey of Ophthalmology.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] Inomata H: "Immunohistochemical study of Vogt-Koyanagi-Harada disease with sun-set sky fundus" Current Eye Research. 9-suppl. 35-40 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sasaki K: "Uveitis induced by various cross-reactive antigens in guinea pigs" Ophthalmic Research. 22. 330-336 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto T: "Class II major histocompatibility complex on melanocyte of Vogt-Koyanagi-Harada disease" Archive of Ophthalmology. 109. 1270-1274 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto T: "Intercellular adhesion molecule-1 on rat comeal endothelium in experimental uveitis" Experimental Eye Research. 56. 241-246 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ishibashi T: "Morphologic study of angiogenesis in vitro" In Vitro Cellular & Developmental Biology. 29A. 91-93 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Murata T: "Experimental rat model of neovascularization arising from the optic disk" Ophthalmic Research. 25. 157-161 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ishibashi T: "Ultrastructure of retinal vessels in diabetic patients" British Journal of Ophthalmology. 77. 574-578 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kohno T: "Ocular manifestations of adult T-cell leukemia/lymphoma.A clinicopathologic study" Ophthalmology. 100. 1794-1799 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Moorthy RS: "Vogt-Koyanagi-Harada syndrome" Survey of Ophthalmology. 77(印刷中). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okada T: "Immunohistochemical study of vitiligo in Vogt-Koyanagi-Harada disease" Elsevier Science Publishers, 1900 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Inomata H: "Vasculitis and intraocular neovascularization in Behcet disease:histopathology of the early and advanced late stages" Kugler Publications, 632 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Rao NA: "Vogt-Koyanagi-Harada syndrome" Mosby Year Book(印刷中), (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Inomata H,Sakamoto T: "Immunohistochemical study of Vogt-Koyanagi-Harada disease with sun-set sky fundus." Current Eye Research 9-supplement. 35-40 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sasaki K: "Uveitis induced by various cross-reactive antigens in guinea pigs." Ophthalmic Research. 22-5. 330-336 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto T,Murata T,Inomata H: "Class II major histocompatibility complex on melanocyte of Vogt-Koyanagi-Harada disease." Archives of Ophthalmology. 109-10. 1270-1274 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Okada T,Sakamoto T,Ishibashi T,Inomata H: "Immunohistochemical study of vitiligo in Vogt-Koyanagi-Harada's disease." In : Current Aspects in Ophthalmology, Elsevier Sciednce Publishers, Amsterdam. 1160-1167 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto T.Takahira K.Sanui H,Kohno T,Inomata H: "Intercellular adhesion molecule-1 on rat corneal endothelium in experimental uveitis." Experimental Eye Research. 56-2. 241-246 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ishibashi T,Murata T,Sueishi K,Inomata H: "morphologic study of angiogenesis in vitro." In Vitro Cellular & Developmental Biology. 29A-2. 91-93 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Inomata H,Ohnishi Y,Kohno T,Tawara A,Ishibashi T: "Retinal Diseases." Compact Ophthalmology, Volume 2, Kanehara & Co Ltd, Tokyo. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Murata T,Ishibashi T,Inomata H: "Experimental rat model of neovascularization arising from the optic disk." Ophthalmic Research. 25-3. 157-161 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kohno T,Uchida H,Inomata H,Fukushima S,Takeshita M,Kikuchi M: "Ocular manifestations of adult T-cell leukemia/lymphoma. A clinicopathologic study." Ophthalmology. 100-12. 1794-1799 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Inomata H,Kohno T,Rao NA,Ryan SJ: "Vasculitis and intraocular neovascularization in Behcet's disease : histopathology of the early and advanced late stages." In : Recent Advences in Uveitis, Kugler Publications, Amsterdam. 349-355 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Moorthy RS,Inomata H,Rao NA: "Vogt-Koyanagi-Harada syndrome." Survey of Ophthalmology. (in press). 77 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Rao NA,Inomata H,Moorthy RS: "Vogt-Koyanagi-Harada syndrome." In : Mosby Year Book. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto T: "Intercellular adhesion molecule-1 on rat corneal endothelium in experimental uveitis" Experimental Eye Research. 56. 241-246 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ishibashi T: "Morphologic study of angiogenesis in vitro" In Vitro Cellular & Developmental Biology. 29A. 91-93 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Murata T: "Experimental rat model of neovascularization arising from the optic disk" Ophthalmic Research. 25. 157-161 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ishibashi T: "Ultrastructure of retinal vessels in diabetic patients" British Journal of Ophthalmology. 77. 574-578 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kohno T: "Ocular manifestations of adult T-cell leukemia/lymphoma.A clinicopathologic" Ophthalmology. 100. 1794-1799 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Moorthy RS: "Vogt-Koyanagi-Harada syndrome" Survey of Ophthalmology. 77 (印刷中). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Inomata H: "Vasculitis and intraocular neovascularization in Behcet disease:hisatopathology of the early and advanced late stages" Kugler Publications, 632 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Rao NA: "Vogt-Koyanagi-Harada syndrome" Mosby Year Book (印刷中), (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 猪俣 孟: "血管新生" 臨床眼科. 46. 406-407 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Murata T: "Immunohistochemical detection of extravasated fibrinogen(fibrin)in human diabetic retina." Graefe's Archive for Clinical and Experimental Ophthalmology. 230. 428-431 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Sakamoto T: "Goniodysgenesis of the eye with arthrogryposis multiplex congenita." Ophthalmologica. 204. 210-214 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 猪俣 孟: "サルコイドーシス" 臨床眼科. 46. 1406-1407 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Murata T: "A case of amniotic band syndrome with bilateral epibulbar choristoma." British Journal of Ophthalmology. 76. 685-687 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] He W: "A reassessment of histologic classification and an immunohistochemical study of 88 retinoblastoma." Cancer. 70. 2901-2908 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 猪俣 孟(分担執筆): "標準眼科学第5版" 医学書院, 288 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 猪俣 孟: "網膜疾患 コンパクト眼科学2" 金原出版, 262 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ishibashi T.: "Altered pearmeability of iris vessels following posterior chamber lens implantation:Anelectron microscopic syudy" Japanese Journal of Ophthalmology. 35. 347-353 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Murata T.: "Corneal choristoma with microphthalmos" Archives of Ophthalmology. 109. 1130-1133 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sakamoto T.: "Class II major histocompatibility complex on melanocyte of VogtーKoyanagiーHarada disease" Archives of Ophthalmology. 109. 1270-1274 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sakamoto T.: "Immunohistochemical and electron microscopical study of nodular fasciitis of the orbit" British Journal of Ophthalmology. 75. 636-638 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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