| Project/Area Number |
03454417
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kagoshima University |
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Principal Investigator |
OHBA Norio Kagoshima University Medicine, Ophthalmology, Professor, 医学部, 教授 (50010070)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Kumiko Medicine, Ophthalmology, Associate, 医学部, 助手 (30217658)
SAMESHIMA Munefumi Medicine, Ophthalmology, Associate, 医学部, 助手 (80041333)
UNOKI Kazuhiko Medicine, Ophthalmology, Instructor, 医学部・附属病院, 講師 (60193926)
ISASHIKI Yasushi Medicine, Ophthalmology, Instructor, 医学部・附属病院, 講師 (70168160)
UEHARA Fumiyuki Medicine, Ophthalmology, Associate professor, 医学部, 助教授 (30168653)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1991: ¥3,400,000 (Direct Cost: ¥3,400,000)
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| Keywords | HTKV-I / HTLV-I associated uveitis / HTLV-I associated retinal degeneration / HLA / HTLV-I / ぶどう膜炎(HAU) / HTLVーI / 網膜脈絡膜変性 / HAM / PCR |
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| Research Abstract |
We studied ocular problems relevant to human T-lymphotropic virus type 1 (HTLV-I).from cliical and basic viewpoints and the following results were obtained. Distinct ocular disorers were found to occur with etiological association to HTLV-I as a part of systemic diseases or as an isolated ocular disease. Two ocular disorders are noticeable, that is HTLV-I associated uveitis (HAU0and HTLV-I associated retinochoroidal degeneration.
1. HTLV-I associated uveitis (HAU). Uveal inflammatory signs and symptoms are developed in patients with HTLV-I associated myelopathy or in HTLV-I carriers., with clinical features consisting of acute granulomatous inflamations in the anterior or posterior segments which resolve in response to corticosteroids. Visual outcome is usually favorable, but recurrent disease is frequent.
2. HTLV-I associated retinochoroidal degeneration (HARD). This pathology is found in occasional patients with HTLV-I associated myelopathy, with features similar to hereditary degeneration.
3. Intraocular synthesis of antibodies to HTLV-I.Aqueous humors from patients with HAU showed evidence of intraocular production of antibodies to HTLV-I while few cases showed proviral DNA of HTLV-I in the aqueous humor, suggesting that HAU represents immune response results rather than ocular infection of the retrovirus.
4. Immunogenetic background of HAU was suggested from HLA studies in patients.
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