Analysis of the oral dyskinesia by using experimental animals.

Research Project

Project/Area Number	03454463
Research Category	Grant-in-Aid for General Scientific Research (B)
Allocation Type	Single-year Grants
Research Field	外科・放射線系歯学
Research Institution	Osaka University
Principal Investigator	MATSUYA Tokuzo The 1st Dept. of Oral & Maxillofacial Surg., Professor Osaka Univ. Fac. of Dentistry, 歯学部, 教授 (40028759)
Co-Investigator(Kenkyū-buntansha)	KOGO Mikihiko The 1st Dept. of Oral & Maxillofacial Surg., Assistant Professor Osaka Univ. Fac, 歯学部, 助手 (20205371) MORIMOTO Toshifumi Dept. of Oral Physiology, Professor Osaka Univ. Fac. of Dentistry, 歯学部, 教授 (20028731)
Project Period (FY)	1991 – 1992
Project Status	Completed (Fiscal Year 1992)
Budget Amount *help	¥5,900,000 (Direct Cost: ¥5,900,000) Fiscal Year 1992: ¥2,600,000 (Direct Cost: ¥2,600,000) Fiscal Year 1991: ¥3,300,000 (Direct Cost: ¥3,300,000)
Keywords	Jaw Movement / Tongue Movement / Respiration
Research Abstract	1.In the first experiment, the physiological function of the stuttering, which is one of the disturbance of speech production, was analyzed, effect of airflow sensory inputs to the airway on the levator veli palatini muscle activity was investigated. As a result, both of supralaryngeal and sublaryngeal airflow inputs facilitated the LVP activity. These result revealed that stuttering is based on the disorder of movement in the soft palate (one of the articulatory organs) which is elicited by hyper sensitivity of airflow through the upper airway. 2.It is supposed that the oral sensory disorder caused oral dyskinesia. In the seconds, the effect of infiltration anesthesia of the hard palate on the involuntary movement of the tongue in the oral dyskinesia rat induced by the D1,D2 agonist (Quinpirole,SKF38393) injection were observed. It is clear that the amount of involuntary movements decreased by the anesthesia of the palate. 3.In monkey, the involuntary movement of mandible and tongue were induced by the set of inadeqate prosthesis. In the other hands, however, by the chronic dosage of haloperidol, it was not induced. Therefore,it is clear that the oral sensory disorder caused the oral dyskinesia.