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Developmental research of a new 1020-site optical recording system for monitoring neural activity of central nervous system.

Research Project

Project/Area Number 03557006
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KAMINO Kohtaro  Tokyo Medical and Dental University, School of Medicine, Professor, 医学部, 教授 (40025630)

Co-Investigator(Kenkyū-buntansha) SATO Yoko  Tokyo Medical adn Dental University, School of Medicine, Instructor, 医学部, 助手 (70251501)
SAKAI Tetsuro  Tokyo Medical and Dental University, School of Medicine, Lecturer, 医学部, 講師 (40153845)
HIROTA Akihiko  Tokyo Medical and Dental University, School of Medicine, Assistant Professor, 医学部, 助教授 (50156717)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥17,300,000 (Direct Cost: ¥17,300,000)
Fiscal Year 1993: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1992: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1991: ¥9,700,000 (Direct Cost: ¥9,700,000)
Keywordscentral nervous system / neural activity / optical recording / 1020-site optical recording system / ニュ-ロン活動
Research Abstract

We have constructed a new 1020-site optical system for simultaneous recording of transmenbrane electrical activity, using a 34 x 34-element photodiode array. This new apparatus permits analysis of the spatio-temporal patterning of neural activity, such as action potentials and postsynaptic potentials, in the central nervous system, at higher spatial and temposal resolutions.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] Kamino,K.: "Optical approaches to ontogeny of electrical activity and related functional organization during early heart development." Physiological Reviews. 70. 53-91 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakai,T.: "Optical determination of impulse conduction velocity during development of the embryonic chick cervical vagus nerve bundle." Journal of Physiology(London). 439. 361-381 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Komuro,H.: "Optical detection of postsynaptic potentials evoked by vagal stimulation in the early embryonic chick brain stem slice." Journal of Physiology(London). 442. 691-649 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Momose-Sato,Y.: "Optical mapping of the early development of the response pattern to vagal stimulation in embryonic chick brain stem." Journal of Physiology(London). 442. 649-669 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato,K.: "Optical monitoring of early appearance of spontaneous membrane potential changes in the embryonic chick medulla oblongata using a voltage-sensitive dye." Neuroscience. 52. 55-62 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato,K.: "Optical assessment of spatial patterning of strength-duration relationship for vagal responses in the early embryonic chick brainstem." Japanese Journal of Physiology. 43. 521-539 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kamino,K.: "Fluorescence Spectroscopy:New Methods and Applications" Springer-Verlag,Berlin,Germany, 310 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 佐藤容子: "膜学実験シリーズ第1巻 生体膜編。" 共立出版、東京, 424 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kamino, K.: "Optical approaches to ontogeny of electrical and related functional organization during early heart development." Physiological Reviews. 70. 53-91 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakai, T., Komuro, H., Katoh, T., Sasaki, H., Momose-Sato, Y.and Kamino, K.: "Optical detemination of impulse conduction velocity during development of the embryonic chick cervical vagues nerve bundle." Journal of Physiology (London). 439. 361-381 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Komuro, H., Sakai, T., Momose-Sato, Y., Hirota, A.and Kamino, K.: "Optical detection of postsynaptic potentials evoked by vagal stimulation in the early embryonic chick brain stem slice" Journal of Physiology (London). 442. 631-648 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Momose-Sato, Y., Sakai, T., Komuro, H., Hirota, A., and Kamino, K.: "Optical mapping of the early development of the response pattern to vagal stimulation in embryonic chick brain stem." Journal of Physiology (London). 442. 649-668 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Momose-Sato, Y., Komuro, H., Sakai, T., Hirota, A.and Kamino, K.: "Optical monitoring of cholinergic postsynaptic potential in the embryonic chick ciliary ganglion using a voltage-sensitive dye." Biomedical Research. 12 Supplement 2. 139-141 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Komuro, H., Momose-Sato, Y., Sakai, T., Hirota, A.and Kamino, K.: "Optical monitoring of early appearance of spotaneous membrane potential changes in the embryonic chick medulla oblomgata using a voltage-sensitive dye." Neuroscience. 52. 55-62 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato, K., Momose-Sato, Y., Sakai, T., Hirota, A.and Kamino, K.: "Optical assessment of spatial patterning of strength-duration relationship for vagal responses in the early embryonic chick brainstem." Japanese Journal of Psysiology. 43. 521-538 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kamino, K., Sakai, T., Momose-Sato, Y., Hirota, A.and Sato, K.: "Optical indications of early appearace of postsynaptic potentials in the embryonic chick brain stem." Japanese Journal of Psysiology. 43, Suppl. 1. S43-S51 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Momose-Sato, Y., Sakai, T., Hirota, A., Sato, K.and Kamino, K.: "Optical monitoring of glutaminergic excitatory postsynaptic potentials from the early developing embryonic chick brain stem slice." Annuals of the New York Academy of Sciences. 707. 454-457 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Momose-Sato, Y., Sakai, T., Hirota, A., Sato, K.and Kamino, K.: "Optical mapping of early embryonic expression of Mg^<2+>/APV-sensitive components of vagal glutaminergic EPSPs in the chick brainstem." Journal of Neuroscience. In press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato, K., Momose-Sato, Y., Sakai, T., Hirota, A.and Kamino, K.: "Optical multiple-site/sectioning recording assessment of neural response areas to glosspharyngel stimulus in the early embryonic chick brainstem." Journal of Neuroscience. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirota, A., Sato, K., Momose-Sato, Y., Sakai, T., and Kamino, K.: "A new simultaneous 1020-site optical recording system for monitoring neural activity using voltage-sensitive dyes." Journal of Neuroscience Methods. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Momose-Sato, Y., Sato, K., Sakai, T., Hirota, A., Matsutani, K.and Kamino, K.: "Evaluative examination of optimal voltage-sensitive dyes for optical monitoring embryonic neural activity." Journal of Neuroscience Methods. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kamino, K., Sakai, T., Momose-Sato, Y., Komuro, H., Hirota, A.and Sato K.: Optical monitoring of postsynaptic potential in the early embryonic avian brain stem using a voltage-sensitive dye. In : Fluorescence Spectroscopy : New Methods and Applications. Ed : O.S Wolfbeis. Springer-Verlag, Berlin, Germany, pp 289-301 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato,K.: "Optical monitoring of early appearance of spontaneous membrane potential changes in the embryonic chick medulla oblongata using a voltage-sensitive dye." Neuroscience. 52. 55-62 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sato,K.: "Optical assessment of spatial patterning of strength-duration relationship for vagal responses in the early embryonic chick brainstem." Japanese Journal of Physiology. 43. 521-539 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kamino,K.: "Optical indications of early appearance of postsynaptic potentials in the embryonic brain stem." Japanese Journal of Physiology. 43 Suppl.1. S43-S51 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Momose-Sato,Y.: "Optical monitoreing of glutaminergic excitatory postsynaptic potentials from the early developing embryonic chick brain stem." Annals of the New York Academy of Sciences. 707. 454-457 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 酒井哲郎: "膜学実験シリーズ第1巻 生体膜編." 共立出版, 424 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 佐藤容子: "膜学実験シリーズ第1巻 生体膜編." 共立出版, 424 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] H.Komuro: "Optical monitoring of early appearance of spontaneous membrane potential changes in the embryonic chick medulla oblongata using a voltage-sensitive dye." Neuroscience. 52. 55-62 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Kamino: "Optical indications of early appearance of postsynaptic potentials in the early embryonic chick brain stem." Japanese Journal of Physiology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Momose-Sato: "Optical monitoring of glutaminergic excitatory post-synaptic potentials from the early developing embryonic chick brain stem slice." Annals of New York Academy of Sciences. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 神野 耕太郎: "心臓興奮伝導の光学的解析ー心電活動のembryonic originー" 心臓. 24. 191-196 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 神野 耕太郎: "膜電位感受性色素を用いた心房興奮伝播の視覚化" 総合臨牀. 41. 642-647 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Kamino: "Fluorescence Spectroscopy:New Methods and Applications" Springer-Verlag,Berlin,Germany Ed.by O.S.Wolfbeis, 310 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kamino.K.: "Optical approaches to ontogeny of electrical activity and related functional organization during early heart development." Physiological Reviews. 71. 53-91 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sakai,T.,Komuro,H.,Katoh,Y.,Sasaki,H.,Momose-Sato,Y.& Kamino,K.: "Optical determination of impulse conduction velocity during development of embryonic chick cervical vagus nerve bundles." Journal of Physiology (London). 439. 361-381 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Komuro,H.,Sakai,T.,Momose-Sato,Y.,Hirota,A.and Kamino,K.: "Optical detection of postsynaptic potentials evoked by vagal stimulation in the early embryonic chick brain stem slice." Journal of Physiology (London). 442. 631-648 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Momose-Sato,Y.,Sakai,T.,Komuro,H.,Hirota,A.and Kamino,K.: "Optical mapping of the early development of the response pattern to vagal stimulation in embryonic chick brain stem." Journal of Physiology (London). 442. 649-668 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Momose-Sato,Y.,Komuro,H.,Sakai,T.,Hirota,A.and Kamino,K.: "Optical monitoring of cholinergic postsynaptic potential in the embryonic chick ciliary ganglion using a voltage-sensitive dve." Biomedical Research. 12,Suppl.2. 139-140 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 神野 耕太郎: "神経科学レビュ-5" 医学書院、東京 伊藤 正男、楢林 博太郎編, 340 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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